Experimentally induced bovine spongiform encephalopathy did not transmit via goat embryos
J Foster, W McKelvey, H Fraser, A Chong, A Ross, D Parnham, W Goldmann and N Hunter Institute for Animal Health, BBSRC Neuropathogenesis Unit, Edinburgh, UK. Jim.Foster@BBSRC.AC.UK Goats are susceptible to experimental challenge with bovine spongiform encephalopathy (BSE). This study set out to inve...
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| Veröffentlicht in: | Journal of general virology 1999-02, Vol.80 (2), p.517-524 |
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| creator | Foster, J McKelvey, W Fraser, H Chong, A Ross, A Parnham, D Goldmann, W Hunter, N |
| description | J Foster, W McKelvey, H Fraser, A Chong, A Ross, D Parnham, W Goldmann and N Hunter
Institute for Animal Health, BBSRC Neuropathogenesis Unit, Edinburgh, UK. Jim.Foster@BBSRC.AC.UK
Goats are susceptible to experimental challenge with bovine spongiform
encephalopathy (BSE). This study set out to investigate whether the
transmission of BSE could occur in goats following the transfer of embryos
from experimentally infected donor females into uninfected recipient
females. The results showed no evidence of transmissible spongiform
encephalopathy disease in any of the offspring which developed from embryos
from infected donors, nor indeed in any of the recipient females used as
surrogate dams. In addition, there was no indication of experimental BSE
spreading as either a venereal infection to males used in mating or by
maternal transmission to offspring born naturally to experimentally
infected donors, although numbers were small. |
| doi_str_mv | 10.1099/0022-1317-80-2-517 |
| format | Article |
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Institute for Animal Health, BBSRC Neuropathogenesis Unit, Edinburgh, UK. Jim.Foster@BBSRC.AC.UK
Goats are susceptible to experimental challenge with bovine spongiform
encephalopathy (BSE). This study set out to investigate whether the
transmission of BSE could occur in goats following the transfer of embryos
from experimentally infected donor females into uninfected recipient
females. The results showed no evidence of transmissible spongiform
encephalopathy disease in any of the offspring which developed from embryos
from infected donors, nor indeed in any of the recipient females used as
surrogate dams. In addition, there was no indication of experimental BSE
spreading as either a venereal infection to males used in mating or by
maternal transmission to offspring born naturally to experimentally
infected donors, although numbers were small.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/0022-1317-80-2-517</identifier><identifier>PMID: 10073715</identifier><language>eng</language><publisher>England: Soc General Microbiol</publisher><subject>Animals ; bovine spongiform encephalopathy ; Cattle ; Embryo Transfer ; Encephalopathy, Bovine Spongiform - metabolism ; Encephalopathy, Bovine Spongiform - pathology ; Encephalopathy, Bovine Spongiform - transmission ; Female ; Goat Diseases - metabolism ; Goat Diseases - pathology ; Goat Diseases - transmission ; Goats ; Male ; Maternal-Fetal Exchange ; Pregnancy ; PrPSc Proteins - metabolism ; Scrapie - metabolism ; Scrapie - pathology ; Scrapie - transmission ; Sheep ; Thalamic Nuclei - metabolism ; Thalamic Nuclei - pathology ; transmissible spongiform encephalopathy</subject><ispartof>Journal of general virology, 1999-02, Vol.80 (2), p.517-524</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-d9d0fa113512dad5b4ec59d110aab13688db133908305def4e02301483d151263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3733,3734,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10073715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foster, J</creatorcontrib><creatorcontrib>McKelvey, W</creatorcontrib><creatorcontrib>Fraser, H</creatorcontrib><creatorcontrib>Chong, A</creatorcontrib><creatorcontrib>Ross, A</creatorcontrib><creatorcontrib>Parnham, D</creatorcontrib><creatorcontrib>Goldmann, W</creatorcontrib><creatorcontrib>Hunter, N</creatorcontrib><title>Experimentally induced bovine spongiform encephalopathy did not transmit via goat embryos</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>J Foster, W McKelvey, H Fraser, A Chong, A Ross, D Parnham, W Goldmann and N Hunter
Institute for Animal Health, BBSRC Neuropathogenesis Unit, Edinburgh, UK. Jim.Foster@BBSRC.AC.UK
Goats are susceptible to experimental challenge with bovine spongiform
encephalopathy (BSE). This study set out to investigate whether the
transmission of BSE could occur in goats following the transfer of embryos
from experimentally infected donor females into uninfected recipient
females. The results showed no evidence of transmissible spongiform
encephalopathy disease in any of the offspring which developed from embryos
from infected donors, nor indeed in any of the recipient females used as
surrogate dams. In addition, there was no indication of experimental BSE
spreading as either a venereal infection to males used in mating or by
maternal transmission to offspring born naturally to experimentally
infected donors, although numbers were small.</description><subject>Animals</subject><subject>bovine spongiform encephalopathy</subject><subject>Cattle</subject><subject>Embryo Transfer</subject><subject>Encephalopathy, Bovine Spongiform - metabolism</subject><subject>Encephalopathy, Bovine Spongiform - pathology</subject><subject>Encephalopathy, Bovine Spongiform - transmission</subject><subject>Female</subject><subject>Goat Diseases - metabolism</subject><subject>Goat Diseases - pathology</subject><subject>Goat Diseases - transmission</subject><subject>Goats</subject><subject>Male</subject><subject>Maternal-Fetal Exchange</subject><subject>Pregnancy</subject><subject>PrPSc Proteins - metabolism</subject><subject>Scrapie - metabolism</subject><subject>Scrapie - pathology</subject><subject>Scrapie - transmission</subject><subject>Sheep</subject><subject>Thalamic Nuclei - metabolism</subject><subject>Thalamic Nuclei - pathology</subject><subject>transmissible spongiform encephalopathy</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1vFDEQhi1ERI7AH6BArqBaMuOP_ShRFD6kSDShoLK869k7o117sfeO3L-PTxdFdFRTzPO-o3kYe4fwCaHrrgGEqFBiU7VQiUpj84JtUNW6EmX9km2egUv2OuffAKiUbl6xSwRoZIN6w37dPiyU_ExhtdN05D64_UCO9_HgA_G8xLD1Y0wzpzDQsrNTXOy6O3LnHQ9x5WuyIc9-5Qdv-TbaldPcp2PMb9jFaKdMb5_mFfv55fb-5lt19-Pr95vPd9WgoF4r1zkYLaLUKJx1ulc06M4hgrU9yrptXRmyg1aCdjQqAiHLI610WCK1vGIfzr1Lin_2lFcz-zzQNNlAcZ9N3dXYKNT_BbGRtRKoCijO4JBizolGsxRDNh0NgjmZNyex5iTWtGCEKeZL6P1T-76fyf0TOasuwMczsPPb3V-fyGwpzL7c6H00B5-eqx4BzFCMsQ</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>Foster, J</creator><creator>McKelvey, W</creator><creator>Fraser, H</creator><creator>Chong, A</creator><creator>Ross, A</creator><creator>Parnham, D</creator><creator>Goldmann, W</creator><creator>Hunter, N</creator><general>Soc General Microbiol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19990201</creationdate><title>Experimentally induced bovine spongiform encephalopathy did not transmit via goat embryos</title><author>Foster, J ; McKelvey, W ; Fraser, H ; Chong, A ; Ross, A ; Parnham, D ; Goldmann, W ; Hunter, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-d9d0fa113512dad5b4ec59d110aab13688db133908305def4e02301483d151263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>bovine spongiform encephalopathy</topic><topic>Cattle</topic><topic>Embryo Transfer</topic><topic>Encephalopathy, Bovine Spongiform - metabolism</topic><topic>Encephalopathy, Bovine Spongiform - pathology</topic><topic>Encephalopathy, Bovine Spongiform - transmission</topic><topic>Female</topic><topic>Goat Diseases - metabolism</topic><topic>Goat Diseases - pathology</topic><topic>Goat Diseases - transmission</topic><topic>Goats</topic><topic>Male</topic><topic>Maternal-Fetal Exchange</topic><topic>Pregnancy</topic><topic>PrPSc Proteins - metabolism</topic><topic>Scrapie - metabolism</topic><topic>Scrapie - pathology</topic><topic>Scrapie - transmission</topic><topic>Sheep</topic><topic>Thalamic Nuclei - metabolism</topic><topic>Thalamic Nuclei - pathology</topic><topic>transmissible spongiform encephalopathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Foster, J</creatorcontrib><creatorcontrib>McKelvey, W</creatorcontrib><creatorcontrib>Fraser, H</creatorcontrib><creatorcontrib>Chong, A</creatorcontrib><creatorcontrib>Ross, A</creatorcontrib><creatorcontrib>Parnham, D</creatorcontrib><creatorcontrib>Goldmann, W</creatorcontrib><creatorcontrib>Hunter, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foster, J</au><au>McKelvey, W</au><au>Fraser, H</au><au>Chong, A</au><au>Ross, A</au><au>Parnham, D</au><au>Goldmann, W</au><au>Hunter, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimentally induced bovine spongiform encephalopathy did not transmit via goat embryos</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>80</volume><issue>2</issue><spage>517</spage><epage>524</epage><pages>517-524</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><abstract>J Foster, W McKelvey, H Fraser, A Chong, A Ross, D Parnham, W Goldmann and N Hunter
Institute for Animal Health, BBSRC Neuropathogenesis Unit, Edinburgh, UK. Jim.Foster@BBSRC.AC.UK
Goats are susceptible to experimental challenge with bovine spongiform
encephalopathy (BSE). This study set out to investigate whether the
transmission of BSE could occur in goats following the transfer of embryos
from experimentally infected donor females into uninfected recipient
females. The results showed no evidence of transmissible spongiform
encephalopathy disease in any of the offspring which developed from embryos
from infected donors, nor indeed in any of the recipient females used as
surrogate dams. In addition, there was no indication of experimental BSE
spreading as either a venereal infection to males used in mating or by
maternal transmission to offspring born naturally to experimentally
infected donors, although numbers were small.</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>10073715</pmid><doi>10.1099/0022-1317-80-2-517</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of general virology, 1999-02, Vol.80 (2), p.517-524 |
| issn | 0022-1317 1465-2099 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69617415 |
| source | MEDLINE; Microbiology Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals bovine spongiform encephalopathy Cattle Embryo Transfer Encephalopathy, Bovine Spongiform - metabolism Encephalopathy, Bovine Spongiform - pathology Encephalopathy, Bovine Spongiform - transmission Female Goat Diseases - metabolism Goat Diseases - pathology Goat Diseases - transmission Goats Male Maternal-Fetal Exchange Pregnancy PrPSc Proteins - metabolism Scrapie - metabolism Scrapie - pathology Scrapie - transmission Sheep Thalamic Nuclei - metabolism Thalamic Nuclei - pathology transmissible spongiform encephalopathy |
| title | Experimentally induced bovine spongiform encephalopathy did not transmit via goat embryos |
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