Differentiation of Human Embryonic Stem Cells into Immunostimulatory Dendritic Cells under Feeder-Free Culture Conditions

Purpose: The objective of this study was to develop a scalable and broadly applicable active immunotherapy approach against cancer, circumventing the limitations typically encountered with autologous vaccination strategies. We hypothesized that human embryonic stem cells (hESC) can serve as a virtua...

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Veröffentlicht in:	Clinical cancer research 2008-10, Vol.14 (19), p.6207-6217
Hauptverfasser:	ZHEN SU, FRYE, Carole, BAE, Kyung-Mi, KELLEY, Vicky, VIEWEG, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen-Presenting Cells - cytology Antineoplastic agents Biological and medical sciences cancer vaccine CD4-Positive T-Lymphocytes - cytology Cell Culture Techniques - methods Cell Differentiation dendritic cells Dendritic Cells - cytology Embryonic Stem Cells - cytology Flow Cytometry - methods Forkhead Transcription Factors - chemistry Histocompatibility Antigens Class II - metabolism human embryonic stem cell Humans Immunotherapy - methods Interleukin-12 - chemistry Medical sciences Peptides - chemistry Pharmacology. Drug treatments RNA, Messenger - metabolism Th1 Cells - metabolism
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