Breast Tumor Kinase Phosphorylates p190RhoGAP to Regulate Rho and Ras and Promote Breast Carcinoma Growth, Migration, and Invasion

Breast tumor kinase (Brk), an Src-like nonreceptor tyrosine kinase, is overexpressed in breast cancer and several other cancer types. Our previous study indicates that Brk promotes cell migration and tumor invasion by phosphorylating the focal adhesion protein paxillin. Here, we report the identific...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-10, Vol.68 (19), p.7779-7787
Hauptverfasser:	SHEN, Che-Hung, CHEN, Hsin-Yi, LIN, Ming-Shien, LI, Fang-Yen, CHANG, Cheng-Chi, KUO, Min-Liang, SETTLEMAN, Jeffrey, CHEN, Ruey-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma - metabolism Carcinoma - pathology Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured Epidermal Growth Factor - pharmacology Guanine Nucleotide Exchange Factors - metabolism Guanine Nucleotide Exchange Factors - physiology Gynecology. Andrology. Obstetrics HeLa Cells Humans Mammary gland diseases Medical sciences Mice Mice, Inbred BALB C Mice, Nude Neoplasm Invasiveness Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Neoplasm Proteins - physiology Pharmacology. Drug treatments Phosphorylation - drug effects Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Protein-Tyrosine Kinases - physiology ras Proteins - metabolism ras Proteins - physiology Repressor Proteins - metabolism Repressor Proteins - physiology rho GTP-Binding Proteins - metabolism rho GTP-Binding Proteins - physiology RNA, Small Interfering - pharmacology Transplantation, Heterologous Tumors
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