Genome-Wide Screen for Systemic Lupus Erythematosus Susceptibility Genes in Multiplex Families

Systemic lupus erythematosus (SLE) is the prototype of human autoimmune diseases. Its genetic component has been suggested by familial aggregation (γs = 20) and twin studies. We have screened the human genome to localize genetic intervals that may contain lupus susceptibility loci in a sample of 188...

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Veröffentlicht in:	Human molecular genetics 1999-04, Vol.8 (4), p.639-644
Hauptverfasser:	Shai, Ruty, Quismorio, Francisco P., Li, Lily, Kwon, Oh-Joong, Morrison, John, Wallace, Daniel J., Neuwelt, C. Michael, Brautbar, Chaim, Gauderman, W. James, Jacob, Chaim O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromosomes, Human, Pair 1 - genetics Classical genetics, quantitative genetics, hybrids DNA - chemistry DNA - genetics Family Health Female Fundamental and applied biological sciences. Psychology Genes - genetics Genetic Linkage Genetic Predisposition to Disease Genetic Testing Genetics of eukaryotes. Biological and molecular evolution Genome, Human Genotype Human Humans Lupus Erythematosus, Systemic - genetics Male Medical sciences Microsatellite Repeats Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sequence Analysis, DNA
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