Crystal structure of a lead-dependent ribozyme revealing metal binding sites relevant to catalysis

The leadzyme is a small RNA motif that catalyzes a site-specific, Pb 2+ -dependent cleavage reaction. As such, it is an example of a metal-dependent RNA enzyme. Here we describe the X-ray crystallographic structure of the leadzyme, which reveals two independent molecules per asymmetric unit. Both mo...

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Veröffentlicht in:	Nature Structural Biology 1999-03, Vol.6 (3), p.261-268
Hauptverfasser:	Wedekind, Joseph E, McKay, David B
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding Sites Biochemistry Biological Microscopy Biomedical and Life Sciences Catalytic Domain Crystallography, X-Ray Lead - metabolism Life Sciences Membrane Biology Nucleic Acid Conformation Protein Structure RNA, Catalytic - chemistry RNA, Catalytic - metabolism
Online-Zugang:	Volltext
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