Prenatal activation of 5-HT2A receptor induces expression of 5-HT1B receptor in phrenic motoneurons and alters the organization of their premotor network in newborn mice

In newborn mice of the control [C3H/HeJ (C3H)] and monoamine oxidase A‐deficient (Tg8) strains, in which levels of endogenous serotonin (5‐HT) were drastically increased, we investigated how 5‐HT system dysregulation affected the maturation of phrenic motoneurons (PhMns), which innervate the diaphra...

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Veröffentlicht in:	The European journal of neuroscience 2008-09, Vol.28 (6), p.1097-1107
Hauptverfasser:	Bras, Hélène, Gaytán, Susana P., Portalier, Paule, Zanella, Sébastien, Pásaro, Rosario, Coulon, Patrice, Hilaire, Gérard
Format:	Artikel
Sprache:	eng
Schlagworte:	2,5‐dimethoxy‐4‐iodoamphetamine hydrochloride 5-dimethoxy-4-iodoamphetamine hydrochloride Amphetamines - pharmacology Animals Animals, Newborn - anatomy & histology Animals, Newborn - metabolism Embryo, Mammalian - anatomy & histology Embryo, Mammalian - drug effects Embryo, Mammalian - physiology Female ketanserin Ketanserin - pharmacology maturation Mice Mice, Inbred C3H Mice, Transgenic Motor Neurons - cytology Motor Neurons - physiology Nerve Net - drug effects Nerve Net - physiology Phrenic Nerve - cytology Pregnancy rabies virus Receptor, Serotonin, 5-HT1B - genetics Receptor, Serotonin, 5-HT1B - metabolism Receptor, Serotonin, 5-HT2A - genetics Receptor, Serotonin, 5-HT2A - metabolism serotonin Serotonin 5-HT2 Receptor Agonists Serotonin 5-HT2 Receptor Antagonists Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology
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