Activation of Signal Transducer and Activator of Transcription 3 through a Phosphomimetic Serine 727 Promotes Prostate Tumorigenesis Independent of Tyrosine 705 Phosphorylation

Aberrantly activated signal transducer and activator of transcription 3 (Stat3) is implicated in the development of various human cancers. Y705 phosphorylation is conventionally thought to be required for Stat3 signal-dependent activation and seems to play an essential role in some malignancies. Rec...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-10, Vol.68 (19), p.7736-7741
Hauptverfasser:	QIN, Haiyan R, KIM, Han-Jong, JLIM, Joon-Young, HURT, Elaine M, KLARMANN, George J, KAWASAKI, Brian T, DUHAGON SERRAT, Maria A, FARRAR, William L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Adhesion - physiology Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic - metabolism Humans Male Medical sciences Mice Mice, Inbred NOD Mice, SCID Mutant Proteins - metabolism Mutant Proteins - physiology Pharmacology. Drug treatments Phosphorylation Point Mutation Prostatic Neoplasms - etiology Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protein-Tyrosine Kinases - metabolism Protein-Tyrosine Kinases - physiology Serine - metabolism STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism STAT3 Transcription Factor - physiology Transplantation, Heterologous Tumors Tyrosine - metabolism
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