Functional dissection of the R domain of cystic fibrosis transmembrane conductance regulator

Exogenously expressed unphosphorylated sub-domains of the R domain block CFTR Cl − channels in the planar lipid bilayer, though the block differs from block with full length R domain. Full length R domain peptide (aa 588–855) blocks CFTR Cl − channels quickly, completely and permanently [1]. Two sub...

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Veröffentlicht in:	FEBS letters 1999-02, Vol.445 (1), p.63-68
Hauptverfasser:	Tasch, Jason E., Zerhusen, Bryan, Zhao, Jiying, Ma, Jianjie, Davis, Pamela B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line CFTR Channel regulation Cystic fibrosis Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - physiology Electrophysiology Gene Expression Humans R domain
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