A Novel Family of Divergent Seven-Transmembrane Proteins: Candidate Odorant Receptors in Drosophila
Although insects have proven to be valuable models for exploring the function, organization, and development of the olfactory system, the receptor molecules that bind odors have not been identified in any insect. We have developed a novel search algorithm, used it to search the Drosophila genomic se...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 1999-02, Vol.22 (2), p.327-338 |
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| container_end_page | 338 |
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| container_title | Neuron (Cambridge, Mass.) |
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| creator | Clyne, Peter J. Warr, Coral G. Freeman, Marc R. Lessing, Derek Kim, Junhyong Carlson, John R. |
| description | Although insects have proven to be valuable models for exploring the function, organization, and development of the olfactory system, the receptor molecules that bind odors have not been identified in any insect. We have developed a novel search algorithm, used it to search the
Drosophila genomic sequence database, and identified a large multigene family encoding seven transmembrane domain proteins that are expressed in olfactory organs. We show that expression is restricted to subsets of olfactory receptor neurons (ORNs) for a number of these genes. Different members of the family initiate expression at different times during antennal development. Some of the genes are not expressed in a mutant of the Acj6 POU-domain transcription factor, a mutant in which a subset of ORNs show abnormal odorant specificities. |
| doi_str_mv | 10.1016/S0896-6273(00)81093-4 |
| format | Article |
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Drosophila genomic sequence database, and identified a large multigene family encoding seven transmembrane domain proteins that are expressed in olfactory organs. We show that expression is restricted to subsets of olfactory receptor neurons (ORNs) for a number of these genes. Different members of the family initiate expression at different times during antennal development. Some of the genes are not expressed in a mutant of the Acj6 POU-domain transcription factor, a mutant in which a subset of ORNs show abnormal odorant specificities.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10069338</pmid><doi>10.1016/S0896-6273(00)81093-4</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neuron (Cambridge, Mass.), 1999-02, Vol.22 (2), p.327-338 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Amino Acid Sequence Animals DNA-Binding Proteins - physiology Drosophila - genetics Drosophila melanogaster Drosophila Proteins Gene Expression Regulation, Developmental - physiology GTP-Binding Proteins - metabolism Molecular Sequence Data Multigene Family - genetics Nerve Tissue Proteins odorant receptors Odorants Olfactory Pathways - physiology olfactory receptor neurons POU Domain Factors Sensory Receptor Cells - physiology Transcription Factors |
| title | A Novel Family of Divergent Seven-Transmembrane Proteins: Candidate Odorant Receptors in Drosophila |
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