Comparison of irbesartan with captopril effects on cardiac hypertrophy and gene expression in heart failure-prone male SHHF/Mcc-fa(cp) rats

Angiotensin-converting enzyme (ACE) inhibitors have proven an effective means to control hypertension and manage cardiac hypertrophy. It is presently unknown if newer specific angiotensin II subtype 1 receptor (AT1R) antagonists are as effective or more effective in treating these conditions compare...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1999-03, Vol.33 (3), p.451-460
Hauptverfasser:	Carraway, J W, Park, S, McCune, S A, Holycross, B J, Radin, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin I - pharmacology Angiotensin II - pharmacology Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Atrial Natriuretic Factor - blood Atrial Natriuretic Factor - drug effects Atrial Natriuretic Factor - genetics Biphenyl Compounds - pharmacology Biphenyl Compounds - therapeutic use Blood Pressure - drug effects Body Weight - drug effects Captopril - pharmacology Captopril - therapeutic use Cardiomegaly - pathology Cardiomegaly - prevention & control Dose-Response Relationship, Drug Echocardiography - drug effects Gene Expression - drug effects Heart Failure - metabolism Heart Failure - physiopathology Heart Failure - prevention & control Irbesartan Isoenzymes - drug effects Male Myosin Heavy Chains - drug effects Organ Size - drug effects Rats Rats, Inbred Strains Receptor, Angiotensin, Type 1 Receptor, Angiotensin, Type 2 Renin - genetics RNA, Messenger - drug effects RNA, Messenger - metabolism Systole Tetrazoles - pharmacology Tetrazoles - therapeutic use
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