Early Immune Activation in Acute Dengue Illness Is Related to Development of Plasma Leakage and Disease Severity
T lymphocyte activation and increased cytokine levels have been described in retrospective studies of children presenting with dengue hemorrhagic fever (DHF). Serial plasma samples obtained in a prospective study of Thai children presenting with
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| Veröffentlicht in: | The Journal of infectious diseases 1999-04, Vol.179 (4), p.755-762 |
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| container_title | The Journal of infectious diseases |
| container_volume | 179 |
| creator | Green, Sharone Vaughn, David W. Kalayanarooj, Siripen Nimmannitya, Suchitra Suntayakorn, Saroj Nisalak, Ananda Lew, Robert Innis, Bruce L. Kurane, Ichiro Rothman, Alan L. Ennis, Francis A. |
| description | T lymphocyte activation and increased cytokine levels have been described in retrospective studies of children presenting with dengue hemorrhagic fever (DHF). Serial plasma samples obtained in a prospective study of Thai children presenting with |
| doi_str_mv | 10.1086/314680 |
| format | Article |
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Serial plasma samples obtained in a prospective study of Thai children presenting with <72 h of fever were studied. Plasma levels of 80-kDa soluble tumor necrosis factor receptors (sTNFRs) were higher in children who developed DHF than in those with dengue fever (DF) or other nondengue febrile illnesses (OFIs) and were correlated with the degree of subsequent plasma leakage. Soluble CD8 and soluble interleukin-2 receptor levels were also elevated in children with DHF compared with those with DF. Interferon-γ and sTNFR 60-kDa levels were higher in children with dengue than in those with OFIs. TNF-α was detectable more often in DHF than in DF or OFIs (P < .05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/314680</identifier><identifier>PMID: 10068569</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Acute Disease ; Adolescent ; Antigens, CD - blood ; Arboviroses ; Biological and medical sciences ; Blood plasma ; Child ; Child, Preschool ; Cytokines - blood ; Dengue ; Dengue - immunology ; Dengue fevers ; Dengue hemorrhagic fever ; Dengue virus ; Diseases ; Fever ; Human viral diseases ; Humans ; Infant ; Infections ; Infectious diseases ; Major Article ; Medical sciences ; Prospective Studies ; Receptors ; Receptors, Tumor Necrosis Factor - blood ; Receptors, Tumor Necrosis Factor, Type I ; Receptors, Tumor Necrosis Factor, Type II ; Serum Albumin - analysis ; T lymphocytes ; Tropical viral diseases ; Viral diseases ; Viruses</subject><ispartof>The Journal of infectious diseases, 1999-04, Vol.179 (4), p.755-762</ispartof><rights>Copyright 1999 Infectious Diseases Society of America</rights><rights>1999 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Apr 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-a8add28cb4508c3bd3c0316999059cb48b51abb22c8e30627c80144626f055833</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30111792$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30111792$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1772181$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10068569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Green, Sharone</creatorcontrib><creatorcontrib>Vaughn, David W.</creatorcontrib><creatorcontrib>Kalayanarooj, Siripen</creatorcontrib><creatorcontrib>Nimmannitya, Suchitra</creatorcontrib><creatorcontrib>Suntayakorn, Saroj</creatorcontrib><creatorcontrib>Nisalak, Ananda</creatorcontrib><creatorcontrib>Lew, Robert</creatorcontrib><creatorcontrib>Innis, Bruce L.</creatorcontrib><creatorcontrib>Kurane, Ichiro</creatorcontrib><creatorcontrib>Rothman, Alan L.</creatorcontrib><creatorcontrib>Ennis, Francis A.</creatorcontrib><title>Early Immune Activation in Acute Dengue Illness Is Related to Development of Plasma Leakage and Disease Severity</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>T lymphocyte activation and increased cytokine levels have been described in retrospective studies of children presenting with dengue hemorrhagic fever (DHF). Serial plasma samples obtained in a prospective study of Thai children presenting with <72 h of fever were studied. Plasma levels of 80-kDa soluble tumor necrosis factor receptors (sTNFRs) were higher in children who developed DHF than in those with dengue fever (DF) or other nondengue febrile illnesses (OFIs) and were correlated with the degree of subsequent plasma leakage. Soluble CD8 and soluble interleukin-2 receptor levels were also elevated in children with DHF compared with those with DF. Interferon-γ and sTNFR 60-kDa levels were higher in children with dengue than in those with OFIs. TNF-α was detectable more often in DHF than in DF or OFIs (P < .05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Antigens, CD - blood</subject><subject>Arboviroses</subject><subject>Biological and medical sciences</subject><subject>Blood plasma</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cytokines - blood</subject><subject>Dengue</subject><subject>Dengue - immunology</subject><subject>Dengue fevers</subject><subject>Dengue hemorrhagic fever</subject><subject>Dengue virus</subject><subject>Diseases</subject><subject>Fever</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Major Article</subject><subject>Medical sciences</subject><subject>Prospective Studies</subject><subject>Receptors</subject><subject>Receptors, Tumor Necrosis Factor - blood</subject><subject>Receptors, Tumor Necrosis Factor, Type I</subject><subject>Receptors, Tumor Necrosis Factor, Type II</subject><subject>Serum Albumin - analysis</subject><subject>T lymphocytes</subject><subject>Tropical viral diseases</subject><subject>Viral diseases</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0VFrFDEUBeBBFLtW_QdKEPFt9CaZZJLHsu3ahQWrVRBfQiZzt8w2M7MmmeL-eyOztOKLTyE5HwfCKYqXFN5TUPIDp5VU8KhYUMHrUkrKHxcLAMZKqrQ-KZ7FuAOAisv6aXFCAaQSUi-K_YUN_kDWfT8NSM5c6u5s6saBdEO-TQnJOQ43E5K19wPGSNaRfEFvE7YkjTm8Qz_uexwSGbfkytvYW7JBe2tvkNihJeddRBuRXGcZunR4XjzZWh_xxfE8Lb6tLr4uL8vNp4_r5dmmdIJBKq2ybcuUayoByvGm5Q44lVprEDq_qkZQ2zSMOYUcJKudAlpVksktCKE4Py3ezb37MP6cMCbTd9Gh93bAcYpGaklZReV_Ia0ZF7yCDN_8A3fjFIb8CcMY11AzgIc2F8YYA27NPnS9DQdDwfxZysxLZfj62DY1PbZ_sXmaDN4egY3O-m2wg-vig6trRhXN7NXMdjGN4T7mQCmtNct5OeddTPjrPrfh1sia18Jcfv9hFPt8tbyWK7PivwEV_LAN</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Green, Sharone</creator><creator>Vaughn, David W.</creator><creator>Kalayanarooj, Siripen</creator><creator>Nimmannitya, Suchitra</creator><creator>Suntayakorn, Saroj</creator><creator>Nisalak, Ananda</creator><creator>Lew, Robert</creator><creator>Innis, Bruce L.</creator><creator>Kurane, Ichiro</creator><creator>Rothman, Alan L.</creator><creator>Ennis, Francis A.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Early Immune Activation in Acute Dengue Illness Is Related to Development of Plasma Leakage and Disease Severity</title><author>Green, Sharone ; Vaughn, David W. ; Kalayanarooj, Siripen ; Nimmannitya, Suchitra ; Suntayakorn, Saroj ; Nisalak, Ananda ; Lew, Robert ; Innis, Bruce L. ; Kurane, Ichiro ; Rothman, Alan L. ; Ennis, Francis A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-a8add28cb4508c3bd3c0316999059cb48b51abb22c8e30627c80144626f055833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Antigens, CD - blood</topic><topic>Arboviroses</topic><topic>Biological and medical sciences</topic><topic>Blood plasma</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cytokines - blood</topic><topic>Dengue</topic><topic>Dengue - immunology</topic><topic>Dengue fevers</topic><topic>Dengue hemorrhagic fever</topic><topic>Dengue virus</topic><topic>Diseases</topic><topic>Fever</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Major Article</topic><topic>Medical sciences</topic><topic>Prospective Studies</topic><topic>Receptors</topic><topic>Receptors, Tumor Necrosis Factor - blood</topic><topic>Receptors, Tumor Necrosis Factor, Type I</topic><topic>Receptors, Tumor Necrosis Factor, Type II</topic><topic>Serum Albumin - analysis</topic><topic>T lymphocytes</topic><topic>Tropical viral diseases</topic><topic>Viral diseases</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Green, Sharone</creatorcontrib><creatorcontrib>Vaughn, David W.</creatorcontrib><creatorcontrib>Kalayanarooj, Siripen</creatorcontrib><creatorcontrib>Nimmannitya, Suchitra</creatorcontrib><creatorcontrib>Suntayakorn, Saroj</creatorcontrib><creatorcontrib>Nisalak, Ananda</creatorcontrib><creatorcontrib>Lew, Robert</creatorcontrib><creatorcontrib>Innis, Bruce L.</creatorcontrib><creatorcontrib>Kurane, Ichiro</creatorcontrib><creatorcontrib>Rothman, Alan L.</creatorcontrib><creatorcontrib>Ennis, Francis A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Green, Sharone</au><au>Vaughn, David W.</au><au>Kalayanarooj, Siripen</au><au>Nimmannitya, Suchitra</au><au>Suntayakorn, Saroj</au><au>Nisalak, Ananda</au><au>Lew, Robert</au><au>Innis, Bruce L.</au><au>Kurane, Ichiro</au><au>Rothman, Alan L.</au><au>Ennis, Francis A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Immune Activation in Acute Dengue Illness Is Related to Development of Plasma Leakage and Disease Severity</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>179</volume><issue>4</issue><spage>755</spage><epage>762</epage><pages>755-762</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>T lymphocyte activation and increased cytokine levels have been described in retrospective studies of children presenting with dengue hemorrhagic fever (DHF). Serial plasma samples obtained in a prospective study of Thai children presenting with <72 h of fever were studied. Plasma levels of 80-kDa soluble tumor necrosis factor receptors (sTNFRs) were higher in children who developed DHF than in those with dengue fever (DF) or other nondengue febrile illnesses (OFIs) and were correlated with the degree of subsequent plasma leakage. Soluble CD8 and soluble interleukin-2 receptor levels were also elevated in children with DHF compared with those with DF. Interferon-γ and sTNFR 60-kDa levels were higher in children with dengue than in those with OFIs. TNF-α was detectable more often in DHF than in DF or OFIs (P < .05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10068569</pmid><doi>10.1086/314680</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 1999-04, Vol.179 (4), p.755-762 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69612416 |
| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Acute Disease Adolescent Antigens, CD - blood Arboviroses Biological and medical sciences Blood plasma Child Child, Preschool Cytokines - blood Dengue Dengue - immunology Dengue fevers Dengue hemorrhagic fever Dengue virus Diseases Fever Human viral diseases Humans Infant Infections Infectious diseases Major Article Medical sciences Prospective Studies Receptors Receptors, Tumor Necrosis Factor - blood Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type II Serum Albumin - analysis T lymphocytes Tropical viral diseases Viral diseases Viruses |
| title | Early Immune Activation in Acute Dengue Illness Is Related to Development of Plasma Leakage and Disease Severity |
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