Comparison of Interferon-γ, Granulocyte Colony-Stimulating Factor, and Granulocyte-Macrophage Colony-Stimulating Factor for Priming Leukocyte-Mediated Hyphal Damage of Opportunistic Fungal Pathogens
Proinflammatory cytokines have been proposed as adjunctive therapeutic agents to enhance the host immune response during infections caused by opportunistic fungi. The study compared the differential in vitro priming effects of interferon-γ (IFN-γ), granulocyte colony-stimulating factor (G-CSF), and...
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| Veröffentlicht in: | The Journal of infectious diseases 1999-04, Vol.179 (4), p.1038-1041 |
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| container_title | The Journal of infectious diseases |
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| creator | Gaviria, J. Milton van Burik, Jo-Anne H. Dale, David C. Root, Richard K. Liles, W. Conrad |
| description | Proinflammatory cytokines have been proposed as adjunctive therapeutic agents to enhance the host immune response during infections caused by opportunistic fungi. The study compared the differential in vitro priming effects of interferon-γ (IFN-γ), granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF) on hyphal damage of opportunistic fungi mediated by isolated neutrophils (polymorphonuclear leukocytes, PMNL) and buffy coat cells (polymorphonuclear leukocytes/peripheral blood mononuclear cells, PMNL/PBMC) from healthy donors. IFN-γ (1000 U/mL) effectively primed both PMNL and PMNL/PBMC for enhanced hyphal damage of Aspergillus fumigatus, Fusarium solani, and Candida albicans. G-CSF (100 ng/mL) increased hyphal damage mediated by both PMNL and PMNL/PBMC against F. solani, and GM-CSF (100 ng/mL) augmented the antifungal activity of PMNL/PBMC against hyphal forms of both F. solani and C. albicans. IFN-γ may be superior to G-CSF or GM-CSF for enhancing the microbicidal activity of PMNL and PMNL/PBMC against opportunistic fungi. |
| doi_str_mv | 10.1086/314679 |
| format | Article |
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Milton ; van Burik, Jo-Anne H. ; Dale, David C. ; Root, Richard K. ; Liles, W. Conrad</creator><creatorcontrib>Gaviria, J. Milton ; van Burik, Jo-Anne H. ; Dale, David C. ; Root, Richard K. ; Liles, W. Conrad</creatorcontrib><description>Proinflammatory cytokines have been proposed as adjunctive therapeutic agents to enhance the host immune response during infections caused by opportunistic fungi. The study compared the differential in vitro priming effects of interferon-γ (IFN-γ), granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF) on hyphal damage of opportunistic fungi mediated by isolated neutrophils (polymorphonuclear leukocytes, PMNL) and buffy coat cells (polymorphonuclear leukocytes/peripheral blood mononuclear cells, PMNL/PBMC) from healthy donors. IFN-γ (1000 U/mL) effectively primed both PMNL and PMNL/PBMC for enhanced hyphal damage of Aspergillus fumigatus, Fusarium solani, and Candida albicans. G-CSF (100 ng/mL) increased hyphal damage mediated by both PMNL and PMNL/PBMC against F. solani, and GM-CSF (100 ng/mL) augmented the antifungal activity of PMNL/PBMC against hyphal forms of both F. solani and C. albicans. IFN-γ may be superior to G-CSF or GM-CSF for enhancing the microbicidal activity of PMNL and PMNL/PBMC against opportunistic fungi.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/314679</identifier><identifier>PMID: 10068606</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Analysis of the immune response. Humoral and cellular immunity ; Aspergillus fumigatus ; Biological and medical sciences ; Candida albicans ; Colony stimulating factors ; Concise Communications ; Cytokines ; Flood damage ; Fundamental and applied biological sciences. 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Milton</creatorcontrib><creatorcontrib>van Burik, Jo-Anne H.</creatorcontrib><creatorcontrib>Dale, David C.</creatorcontrib><creatorcontrib>Root, Richard K.</creatorcontrib><creatorcontrib>Liles, W. Conrad</creatorcontrib><title>Comparison of Interferon-γ, Granulocyte Colony-Stimulating Factor, and Granulocyte-Macrophage Colony-Stimulating Factor for Priming Leukocyte-Mediated Hyphal Damage of Opportunistic Fungal Pathogens</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Proinflammatory cytokines have been proposed as adjunctive therapeutic agents to enhance the host immune response during infections caused by opportunistic fungi. The study compared the differential in vitro priming effects of interferon-γ (IFN-γ), granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF) on hyphal damage of opportunistic fungi mediated by isolated neutrophils (polymorphonuclear leukocytes, PMNL) and buffy coat cells (polymorphonuclear leukocytes/peripheral blood mononuclear cells, PMNL/PBMC) from healthy donors. IFN-γ (1000 U/mL) effectively primed both PMNL and PMNL/PBMC for enhanced hyphal damage of Aspergillus fumigatus, Fusarium solani, and Candida albicans. G-CSF (100 ng/mL) increased hyphal damage mediated by both PMNL and PMNL/PBMC against F. solani, and GM-CSF (100 ng/mL) augmented the antifungal activity of PMNL/PBMC against hyphal forms of both F. solani and C. albicans. IFN-γ may be superior to G-CSF or GM-CSF for enhancing the microbicidal activity of PMNL and PMNL/PBMC against opportunistic fungi.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Aspergillus fumigatus</subject><subject>Biological and medical sciences</subject><subject>Candida albicans</subject><subject>Colony stimulating factors</subject><subject>Concise Communications</subject><subject>Cytokines</subject><subject>Flood damage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Fungi</subject><subject>Fungi - immunology</subject><subject>Fusarium solani</subject><subject>Granulocyte Colony-Stimulating Factor - pharmacology</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology</subject><subject>Granulocytes</subject><subject>Humans</subject><subject>Hyphae</subject><subject>Immunobiology</subject><subject>Interferon-gamma - pharmacology</subject><subject>Leukocytes - immunology</subject><subject>Neutrophils</subject><subject>Neutrophils - immunology</subject><subject>Opportunistic behavior</subject><subject>Organs and cells involved in the immune response</subject><subject>Pathogens</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhSMEotMCbwDKArFq4Po_WcLQ6VQa1EGAQGwsx3GmaRM72I7EPBcPwY5nwqMZtV3BwrLk891zrXOy7BmC1whK_oYgykX1IJshRkTBOSIPsxkAxgUqq-ooOw7hGgAo4eJxdoQAeMmBz7LfczeMynfB2dy1-YWNxrfGO1v8-XWan3tlp97pbTT53PXObotPsRumXsXObvKF0tH501zZ5j5afFDau_FKbf4xlbfprH037J5WZro5jJqmU9E0-XKbDPr8vRp2Nulrl-PofJxsF2Kn88VkN0leq3jlNsaGJ9mjVvXBPD3cJ9mXxdnn-bJYXZ5fzN-uCk2xiAWrKt4QDQIYtERXpSCGU11ThrFRpmaga1CkrQVURmOgFasxK7lRipqGUXKSvdr7jt79mEyIcuiCNn2vrHFTkLziCKOq_C-IBKaAEdyBKbMQvGnlmFJRfisRyF23ct9tAl8cHKd6MM09bF9mAl4eABW06tvUiO7CHScE5gwl7Pkeuw6ph1uZAEKoxLs9xV5PSZuft7ryN5ILIphcfvsuvy6Bso-rtXxH_gKLwchK</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Gaviria, J. Milton</creator><creator>van Burik, Jo-Anne H.</creator><creator>Dale, David C.</creator><creator>Root, Richard K.</creator><creator>Liles, W. Conrad</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Comparison of Interferon-γ, Granulocyte Colony-Stimulating Factor, and Granulocyte-Macrophage Colony-Stimulating Factor for Priming Leukocyte-Mediated Hyphal Damage of Opportunistic Fungal Pathogens</title><author>Gaviria, J. Milton ; van Burik, Jo-Anne H. ; Dale, David C. ; Root, Richard K. ; Liles, W. Conrad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-5996d3c07050f3c9873e64cb4522eaeb50cb0a3fb709ec20495b2586eaa4ed543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Aspergillus fumigatus</topic><topic>Biological and medical sciences</topic><topic>Candida albicans</topic><topic>Colony stimulating factors</topic><topic>Concise Communications</topic><topic>Cytokines</topic><topic>Flood damage</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Fungi</topic><topic>Fungi - immunology</topic><topic>Fusarium solani</topic><topic>Granulocyte Colony-Stimulating Factor - pharmacology</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology</topic><topic>Granulocytes</topic><topic>Humans</topic><topic>Hyphae</topic><topic>Immunobiology</topic><topic>Interferon-gamma - pharmacology</topic><topic>Leukocytes - immunology</topic><topic>Neutrophils</topic><topic>Neutrophils - immunology</topic><topic>Opportunistic behavior</topic><topic>Organs and cells involved in the immune response</topic><topic>Pathogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaviria, J. Milton</creatorcontrib><creatorcontrib>van Burik, Jo-Anne H.</creatorcontrib><creatorcontrib>Dale, David C.</creatorcontrib><creatorcontrib>Root, Richard K.</creatorcontrib><creatorcontrib>Liles, W. Conrad</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaviria, J. Milton</au><au>van Burik, Jo-Anne H.</au><au>Dale, David C.</au><au>Root, Richard K.</au><au>Liles, W. Conrad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Interferon-γ, Granulocyte Colony-Stimulating Factor, and Granulocyte-Macrophage Colony-Stimulating Factor for Priming Leukocyte-Mediated Hyphal Damage of Opportunistic Fungal Pathogens</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>179</volume><issue>4</issue><spage>1038</spage><epage>1041</epage><pages>1038-1041</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Proinflammatory cytokines have been proposed as adjunctive therapeutic agents to enhance the host immune response during infections caused by opportunistic fungi. The study compared the differential in vitro priming effects of interferon-γ (IFN-γ), granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF) on hyphal damage of opportunistic fungi mediated by isolated neutrophils (polymorphonuclear leukocytes, PMNL) and buffy coat cells (polymorphonuclear leukocytes/peripheral blood mononuclear cells, PMNL/PBMC) from healthy donors. IFN-γ (1000 U/mL) effectively primed both PMNL and PMNL/PBMC for enhanced hyphal damage of Aspergillus fumigatus, Fusarium solani, and Candida albicans. G-CSF (100 ng/mL) increased hyphal damage mediated by both PMNL and PMNL/PBMC against F. solani, and GM-CSF (100 ng/mL) augmented the antifungal activity of PMNL/PBMC against hyphal forms of both F. solani and C. albicans. IFN-γ may be superior to G-CSF or GM-CSF for enhancing the microbicidal activity of PMNL and PMNL/PBMC against opportunistic fungi.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10068606</pmid><doi>10.1086/314679</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1999-04, Vol.179 (4), p.1038-1041 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69612198 |
| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Analysis of the immune response. Humoral and cellular immunity Aspergillus fumigatus Biological and medical sciences Candida albicans Colony stimulating factors Concise Communications Cytokines Flood damage Fundamental and applied biological sciences. Psychology Fundamental immunology Fungi Fungi - immunology Fusarium solani Granulocyte Colony-Stimulating Factor - pharmacology Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Granulocytes Humans Hyphae Immunobiology Interferon-gamma - pharmacology Leukocytes - immunology Neutrophils Neutrophils - immunology Opportunistic behavior Organs and cells involved in the immune response Pathogens |
| title | Comparison of Interferon-γ, Granulocyte Colony-Stimulating Factor, and Granulocyte-Macrophage Colony-Stimulating Factor for Priming Leukocyte-Mediated Hyphal Damage of Opportunistic Fungal Pathogens |
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