Specific Inhibitors of p38 and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Pathways Block Inducible Nitric Oxide Synthase and Tumor Necrosis Factor Accumulation in Murine Macrophages Stimulated with Lipopolysaccharide and Interferon-γ

Whether p38 and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase cascades are required for inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in RAW 264.7 murine macrophages exposed to lipopolysaccharide (LPS) plus recombinant interferon-γ...

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Veröffentlicht in:	The Journal of infectious diseases 1999-04, Vol.179 (4), p.939-944
Hauptverfasser:	Ajizian, Samuel J., English, B. Keith, Meals, Elizabeth A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases - physiology Cells, Cultured Cytokines Dose-Response Relationship, Drug Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Imidazoles - pharmacology Immunobiology Inhibitory concentration 50 Interferon-gamma - pharmacology Lipopolysaccharides Lipopolysaccharides - pharmacology Macrophages Major Article Mice Mitogen-Activated Protein Kinases Modulation of the immune response (stimulation, suppression) Nitric Oxide - biosynthesis Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type II Oxides p38 Mitogen-Activated Protein Kinases Proteins Pyridines - pharmacology Secretion Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis Tumor necrosis factors Up regulation
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