Epidemiology of rotavirus in infants and protection against symptomatic illness afforded by primary infection and vaccination
This study assessed the frequency of symptomatic and asymptomatic primary and secondary infections with rotavirus in children under 24 months and determined protection against symptomatic illness afforded by rhesus and human-rhesus rotavirus reassortant vaccines. Successive cohorts of children ( n=2...
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| Veröffentlicht in: | Vaccine 1999-02, Vol.17 (7), p.745-753 |
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| creator | Mrukowicz, Jacek Z Thompson, Juliette Reed, George W Tollefson, Sharon J Kobayashi, Masaaki Araki, Kozuko Wright, Peter F |
| description | This study assessed the frequency of symptomatic and asymptomatic primary and secondary infections with rotavirus in children under 24 months and determined protection against symptomatic illness afforded by rhesus and human-rhesus rotavirus reassortant vaccines. Successive cohorts of children (
n=236) were followed through five winter rotavirus seasons with cultures of each reported episode of diarrheal disease and serologic determination of rotavirus exposure on paired sera bracketing the winter. An average of 46% of children experienced rotavirus infection in each season with almost all infected by two years of age. The relative risk of rotavirus associated gastroenteritis in naive children versus naturally immune children was 2.4 (1.1, 5.3). The relative risk of rotavirus associated gastroenteritis in naive children versus vaccinees was 4.1 (1.6, 10.7). In a community with predominantly serotype G1 rotavirus rhesus rotavirus-based vaccines are as protective against rotavirus gastroenteritis as prior natural infection. |
| doi_str_mv | 10.1016/S0264-410X(98)00258-8 |
| format | Article |
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n=236) were followed through five winter rotavirus seasons with cultures of each reported episode of diarrheal disease and serologic determination of rotavirus exposure on paired sera bracketing the winter. An average of 46% of children experienced rotavirus infection in each season with almost all infected by two years of age. The relative risk of rotavirus associated gastroenteritis in naive children versus naturally immune children was 2.4 (1.1, 5.3). The relative risk of rotavirus associated gastroenteritis in naive children versus vaccinees was 4.1 (1.6, 10.7). In a community with predominantly serotype G1 rotavirus rhesus rotavirus-based vaccines are as protective against rotavirus gastroenteritis as prior natural infection.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(98)00258-8</identifier><identifier>PMID: 10067679</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Antibodies, Viral - biosynthesis ; Antibodies, Viral - blood ; Biological and medical sciences ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenteritis - epidemiology ; Gastroenteritis - immunology ; Gastroenteritis - prevention & control ; Humans ; Immunity, Innate - immunology ; Immunoglobulin G - biosynthesis ; Immunoglobulin G - blood ; Infant ; Male ; Microbiology ; Prospective Studies ; Rotavirus ; Rotavirus - immunology ; Rotavirus Infections - epidemiology ; Rotavirus Infections - immunology ; Rotavirus Infections - prevention & control ; Vaccines ; Viral Vaccines - immunology ; Viral Vaccines - therapeutic use ; Virology</subject><ispartof>Vaccine, 1999-02, Vol.17 (7), p.745-753</ispartof><rights>1999 Elsevier Science Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-705ff8936fa61f75f1e3efc9b80d1c3d79fca43e782149f37cd4e267c64dc0853</citedby><cites>FETCH-LOGICAL-c421t-705ff8936fa61f75f1e3efc9b80d1c3d79fca43e782149f37cd4e267c64dc0853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0264-410X(98)00258-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27925,27926,45996</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1716150$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10067679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mrukowicz, Jacek Z</creatorcontrib><creatorcontrib>Thompson, Juliette</creatorcontrib><creatorcontrib>Reed, George W</creatorcontrib><creatorcontrib>Tollefson, Sharon J</creatorcontrib><creatorcontrib>Kobayashi, Masaaki</creatorcontrib><creatorcontrib>Araki, Kozuko</creatorcontrib><creatorcontrib>Wright, Peter F</creatorcontrib><title>Epidemiology of rotavirus in infants and protection against symptomatic illness afforded by primary infection and vaccination</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>This study assessed the frequency of symptomatic and asymptomatic primary and secondary infections with rotavirus in children under 24 months and determined protection against symptomatic illness afforded by rhesus and human-rhesus rotavirus reassortant vaccines. Successive cohorts of children (
n=236) were followed through five winter rotavirus seasons with cultures of each reported episode of diarrheal disease and serologic determination of rotavirus exposure on paired sera bracketing the winter. An average of 46% of children experienced rotavirus infection in each season with almost all infected by two years of age. The relative risk of rotavirus associated gastroenteritis in naive children versus naturally immune children was 2.4 (1.1, 5.3). The relative risk of rotavirus associated gastroenteritis in naive children versus vaccinees was 4.1 (1.6, 10.7). In a community with predominantly serotype G1 rotavirus rhesus rotavirus-based vaccines are as protective against rotavirus gastroenteritis as prior natural infection.</description><subject>Antibodies, Viral - biosynthesis</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenteritis - epidemiology</subject><subject>Gastroenteritis - immunology</subject><subject>Gastroenteritis - prevention & control</subject><subject>Humans</subject><subject>Immunity, Innate - immunology</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin G - blood</subject><subject>Infant</subject><subject>Male</subject><subject>Microbiology</subject><subject>Prospective Studies</subject><subject>Rotavirus</subject><subject>Rotavirus - immunology</subject><subject>Rotavirus Infections - epidemiology</subject><subject>Rotavirus Infections - immunology</subject><subject>Rotavirus Infections - prevention & control</subject><subject>Vaccines</subject><subject>Viral Vaccines - immunology</subject><subject>Viral Vaccines - therapeutic use</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rVDEYhUOp2LH6E1qyKKKLq3nvRz5WIqWtQsGFCu5CJnlTIvcm0-TOwCz872Y60-quEAghzznJew4hZ8A-AAP-8Ttred_0wH69U_I9Y-0gG3lEFiBF17QDyGOyeEJOyKtSfjPGhg7US3ICjHHBhVqQP1er4HAKaUx3W5o8zWk2m5DXhYZYlzdxLtRER1f1Bu0cUqTmzoRYZlq202pOk5mDpWEcI5aKep-yQ0eX2yoJk8nbnc2jshptjLUhmt35NXnhzVjwzWE_JT-vr35cfmluv918vfx829i-hbkRbPBeqo57w8GLwQN26K1aSubAdk4ob03foZAt9Mp3wroeWy4s751lcuhOydu9bx3ifo1l1lMoFsfRREzrorniwESrngVBgJKi5xUc9qDNqZSMXh-G1cD0riD9UJDepa-V1A8FaVl154cH1ssJ3X-qfSMVuDgAplgz-myiDeUfJ4DDwCr2aY9hjW0TMOtiA0aLLuSatXYpPPOTv2d6sFQ</recordid><startdate>19990226</startdate><enddate>19990226</enddate><creator>Mrukowicz, Jacek Z</creator><creator>Thompson, Juliette</creator><creator>Reed, George W</creator><creator>Tollefson, Sharon J</creator><creator>Kobayashi, Masaaki</creator><creator>Araki, Kozuko</creator><creator>Wright, Peter F</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19990226</creationdate><title>Epidemiology of rotavirus in infants and protection against symptomatic illness afforded by primary infection and vaccination</title><author>Mrukowicz, Jacek Z ; Thompson, Juliette ; Reed, George W ; Tollefson, Sharon J ; Kobayashi, Masaaki ; Araki, Kozuko ; Wright, Peter F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-705ff8936fa61f75f1e3efc9b80d1c3d79fca43e782149f37cd4e267c64dc0853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Antibodies, Viral - biosynthesis</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenteritis - epidemiology</topic><topic>Gastroenteritis - immunology</topic><topic>Gastroenteritis - prevention & control</topic><topic>Humans</topic><topic>Immunity, Innate - immunology</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin G - blood</topic><topic>Infant</topic><topic>Male</topic><topic>Microbiology</topic><topic>Prospective Studies</topic><topic>Rotavirus</topic><topic>Rotavirus - immunology</topic><topic>Rotavirus Infections - epidemiology</topic><topic>Rotavirus Infections - immunology</topic><topic>Rotavirus Infections - prevention & control</topic><topic>Vaccines</topic><topic>Viral Vaccines - immunology</topic><topic>Viral Vaccines - therapeutic use</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mrukowicz, Jacek Z</creatorcontrib><creatorcontrib>Thompson, Juliette</creatorcontrib><creatorcontrib>Reed, George W</creatorcontrib><creatorcontrib>Tollefson, Sharon J</creatorcontrib><creatorcontrib>Kobayashi, Masaaki</creatorcontrib><creatorcontrib>Araki, Kozuko</creatorcontrib><creatorcontrib>Wright, Peter F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mrukowicz, Jacek Z</au><au>Thompson, Juliette</au><au>Reed, George W</au><au>Tollefson, Sharon J</au><au>Kobayashi, Masaaki</au><au>Araki, Kozuko</au><au>Wright, Peter F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of rotavirus in infants and protection against symptomatic illness afforded by primary infection and vaccination</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>1999-02-26</date><risdate>1999</risdate><volume>17</volume><issue>7</issue><spage>745</spage><epage>753</epage><pages>745-753</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>This study assessed the frequency of symptomatic and asymptomatic primary and secondary infections with rotavirus in children under 24 months and determined protection against symptomatic illness afforded by rhesus and human-rhesus rotavirus reassortant vaccines. Successive cohorts of children (
n=236) were followed through five winter rotavirus seasons with cultures of each reported episode of diarrheal disease and serologic determination of rotavirus exposure on paired sera bracketing the winter. An average of 46% of children experienced rotavirus infection in each season with almost all infected by two years of age. The relative risk of rotavirus associated gastroenteritis in naive children versus naturally immune children was 2.4 (1.1, 5.3). The relative risk of rotavirus associated gastroenteritis in naive children versus vaccinees was 4.1 (1.6, 10.7). In a community with predominantly serotype G1 rotavirus rhesus rotavirus-based vaccines are as protective against rotavirus gastroenteritis as prior natural infection.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>10067679</pmid><doi>10.1016/S0264-410X(98)00258-8</doi><tpages>9</tpages></addata></record> |
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| subjects | Antibodies, Viral - biosynthesis Antibodies, Viral - blood Biological and medical sciences Epidemiology Female Fundamental and applied biological sciences. Psychology Gastroenteritis - epidemiology Gastroenteritis - immunology Gastroenteritis - prevention & control Humans Immunity, Innate - immunology Immunoglobulin G - biosynthesis Immunoglobulin G - blood Infant Male Microbiology Prospective Studies Rotavirus Rotavirus - immunology Rotavirus Infections - epidemiology Rotavirus Infections - immunology Rotavirus Infections - prevention & control Vaccines Viral Vaccines - immunology Viral Vaccines - therapeutic use Virology |
| title | Epidemiology of rotavirus in infants and protection against symptomatic illness afforded by primary infection and vaccination |
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