AMPA/kainate receptors permeable to divalent cations in amphibian central nervous system
Glutamate receptors have been studied extensively in mammals but less explored in lower vertebrates. These receptors are present in amphibians. Using a recent method based upon agonist-induced cobalt uptake, we were able to detect the presence of functional α-amino-3-hydroxy-5-methyl-4-isoxazoleprop...
Gespeichert in:
| Veröffentlicht in: | Life sciences (1973) 1999, Vol.64 (8), p.607-616 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 616 |
|---|---|
| container_issue | 8 |
| container_start_page | 607 |
| container_title | Life sciences (1973) |
| container_volume | 64 |
| creator | Estabel, Jeanne König, Norbert Exbrayat, Jean-Marie |
| description | Glutamate receptors have been studied extensively in mammals but less explored in lower vertebrates. These receptors are present in amphibians. Using a recent method based upon agonist-induced cobalt uptake, we were able to detect the presence of functional α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors permeable to divalent cations in tadpoles and in adults. The uptake specificity was checked by co-application of an antagonist. We studied the distribution of receptor-bearing cells in the principal brain regions. The distribution was similar in the two species studied:
Rana esculenta (green frog) and
Bufo bufo (common toad). The high number of cobalt-positive cells suggests that the AMPA/kainate receptors permeable to divalent cations play an important role in the anuran nervous system. |
| doi_str_mv | 10.1016/S0024-3205(98)00603-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69609909</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0024320598006031</els_id><sourcerecordid>17576701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c458t-da9af89edf0325f61536f2d1fe42067f8c437db06b257247d9bd94f98b1b073c3</originalsourceid><addsrcrecordid>eNqFkE1LHTEUhoO06K31J1iyKnYx9WQySSarcpF-gaKggruQSU4w7Xw1yb3gv-9cr5TuXJ3Fed7zHh5CThl8ZsDk-S1A3VS8BnGm208AEnjFDsiKtUpXIDl7Q1b_kCPyLudfACCE4ofkiC28FnWzIg_rq5v1-W8bR1uQJnQ4lyllOmMa0HY90jJRH7e2x7FQZ0ucxkzjSO0wP8Yu2pG6ZZNsT0dM22mTaX7KBYf35G2wfcaTl3lM7r99vbv4UV1ef_95sb6sXCPaUnmrbWg1-gC8FkEywWWoPQvY1CBVaF3Dle9AdrVQdaO87rxugm471oHijh-Tj_u7c5r-bDAXM8TssO_tiMs3RmoJWoN-FWRKKKmALaDYgy5NOScMZk5xsOnJMDA79-bZvdmJNbo1z-7NLvfhpWDTDej_S-1lL8CXPYCLj23EZLKLODr0cRFfjJ_iKxV_AQx8k9g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17576701</pqid></control><display><type>article</type><title>AMPA/kainate receptors permeable to divalent cations in amphibian central nervous system</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Estabel, Jeanne ; König, Norbert ; Exbrayat, Jean-Marie</creator><creatorcontrib>Estabel, Jeanne ; König, Norbert ; Exbrayat, Jean-Marie</creatorcontrib><description>Glutamate receptors have been studied extensively in mammals but less explored in lower vertebrates. These receptors are present in amphibians. Using a recent method based upon agonist-induced cobalt uptake, we were able to detect the presence of functional α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors permeable to divalent cations in tadpoles and in adults. The uptake specificity was checked by co-application of an antagonist. We studied the distribution of receptor-bearing cells in the principal brain regions. The distribution was similar in the two species studied:
Rana esculenta (green frog) and
Bufo bufo (common toad). The high number of cobalt-positive cells suggests that the AMPA/kainate receptors permeable to divalent cations play an important role in the anuran nervous system.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(98)00603-1</identifier><identifier>PMID: 10069524</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>amphibians ; Animals ; Anura - growth & development ; Anura - metabolism ; Brain - drug effects ; Brain - metabolism ; Bufo bufo ; calcium ; Cations, Divalent - metabolism ; Cell Count - drug effects ; Cell Size - drug effects ; Cobalt - metabolism ; glutamate ; In Vitro Techniques ; Larva ; Metamorphosis, Biological ; Neurons - drug effects ; Neurons - metabolism ; Pigments, Biological ; Quinoxalines - pharmacology ; Rana esculenta ; Receptors, AMPA - antagonists & inhibitors ; Receptors, AMPA - metabolism ; Receptors, Kainic Acid - antagonists & inhibitors ; Receptors, Kainic Acid - metabolism ; Spinal Cord - cytology ; Spinal Cord - drug effects ; Spinal Cord - metabolism ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors</subject><ispartof>Life sciences (1973), 1999, Vol.64 (8), p.607-616</ispartof><rights>1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-da9af89edf0325f61536f2d1fe42067f8c437db06b257247d9bd94f98b1b073c3</citedby><cites>FETCH-LOGICAL-c458t-da9af89edf0325f61536f2d1fe42067f8c437db06b257247d9bd94f98b1b073c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320598006031$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10069524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Estabel, Jeanne</creatorcontrib><creatorcontrib>König, Norbert</creatorcontrib><creatorcontrib>Exbrayat, Jean-Marie</creatorcontrib><title>AMPA/kainate receptors permeable to divalent cations in amphibian central nervous system</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Glutamate receptors have been studied extensively in mammals but less explored in lower vertebrates. These receptors are present in amphibians. Using a recent method based upon agonist-induced cobalt uptake, we were able to detect the presence of functional α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors permeable to divalent cations in tadpoles and in adults. The uptake specificity was checked by co-application of an antagonist. We studied the distribution of receptor-bearing cells in the principal brain regions. The distribution was similar in the two species studied:
Rana esculenta (green frog) and
Bufo bufo (common toad). The high number of cobalt-positive cells suggests that the AMPA/kainate receptors permeable to divalent cations play an important role in the anuran nervous system.</description><subject>amphibians</subject><subject>Animals</subject><subject>Anura - growth & development</subject><subject>Anura - metabolism</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Bufo bufo</subject><subject>calcium</subject><subject>Cations, Divalent - metabolism</subject><subject>Cell Count - drug effects</subject><subject>Cell Size - drug effects</subject><subject>Cobalt - metabolism</subject><subject>glutamate</subject><subject>In Vitro Techniques</subject><subject>Larva</subject><subject>Metamorphosis, Biological</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Pigments, Biological</subject><subject>Quinoxalines - pharmacology</subject><subject>Rana esculenta</subject><subject>Receptors, AMPA - antagonists & inhibitors</subject><subject>Receptors, AMPA - metabolism</subject><subject>Receptors, Kainic Acid - antagonists & inhibitors</subject><subject>Receptors, Kainic Acid - metabolism</subject><subject>Spinal Cord - cytology</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - metabolism</subject><subject>α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LHTEUhoO06K31J1iyKnYx9WQySSarcpF-gaKggruQSU4w7Xw1yb3gv-9cr5TuXJ3Fed7zHh5CThl8ZsDk-S1A3VS8BnGm208AEnjFDsiKtUpXIDl7Q1b_kCPyLudfACCE4ofkiC28FnWzIg_rq5v1-W8bR1uQJnQ4lyllOmMa0HY90jJRH7e2x7FQZ0ucxkzjSO0wP8Yu2pG6ZZNsT0dM22mTaX7KBYf35G2wfcaTl3lM7r99vbv4UV1ef_95sb6sXCPaUnmrbWg1-gC8FkEywWWoPQvY1CBVaF3Dle9AdrVQdaO87rxugm471oHijh-Tj_u7c5r-bDAXM8TssO_tiMs3RmoJWoN-FWRKKKmALaDYgy5NOScMZk5xsOnJMDA79-bZvdmJNbo1z-7NLvfhpWDTDej_S-1lL8CXPYCLj23EZLKLODr0cRFfjJ_iKxV_AQx8k9g</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Estabel, Jeanne</creator><creator>König, Norbert</creator><creator>Exbrayat, Jean-Marie</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>AMPA/kainate receptors permeable to divalent cations in amphibian central nervous system</title><author>Estabel, Jeanne ; König, Norbert ; Exbrayat, Jean-Marie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-da9af89edf0325f61536f2d1fe42067f8c437db06b257247d9bd94f98b1b073c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>amphibians</topic><topic>Animals</topic><topic>Anura - growth & development</topic><topic>Anura - metabolism</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Bufo bufo</topic><topic>calcium</topic><topic>Cations, Divalent - metabolism</topic><topic>Cell Count - drug effects</topic><topic>Cell Size - drug effects</topic><topic>Cobalt - metabolism</topic><topic>glutamate</topic><topic>In Vitro Techniques</topic><topic>Larva</topic><topic>Metamorphosis, Biological</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Pigments, Biological</topic><topic>Quinoxalines - pharmacology</topic><topic>Rana esculenta</topic><topic>Receptors, AMPA - antagonists & inhibitors</topic><topic>Receptors, AMPA - metabolism</topic><topic>Receptors, Kainic Acid - antagonists & inhibitors</topic><topic>Receptors, Kainic Acid - metabolism</topic><topic>Spinal Cord - cytology</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - metabolism</topic><topic>α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Estabel, Jeanne</creatorcontrib><creatorcontrib>König, Norbert</creatorcontrib><creatorcontrib>Exbrayat, Jean-Marie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Estabel, Jeanne</au><au>König, Norbert</au><au>Exbrayat, Jean-Marie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AMPA/kainate receptors permeable to divalent cations in amphibian central nervous system</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1999</date><risdate>1999</risdate><volume>64</volume><issue>8</issue><spage>607</spage><epage>616</epage><pages>607-616</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Glutamate receptors have been studied extensively in mammals but less explored in lower vertebrates. These receptors are present in amphibians. Using a recent method based upon agonist-induced cobalt uptake, we were able to detect the presence of functional α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors permeable to divalent cations in tadpoles and in adults. The uptake specificity was checked by co-application of an antagonist. We studied the distribution of receptor-bearing cells in the principal brain regions. The distribution was similar in the two species studied:
Rana esculenta (green frog) and
Bufo bufo (common toad). The high number of cobalt-positive cells suggests that the AMPA/kainate receptors permeable to divalent cations play an important role in the anuran nervous system.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>10069524</pmid><doi>10.1016/S0024-3205(98)00603-1</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1999, Vol.64 (8), p.607-616 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69609909 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | amphibians Animals Anura - growth & development Anura - metabolism Brain - drug effects Brain - metabolism Bufo bufo calcium Cations, Divalent - metabolism Cell Count - drug effects Cell Size - drug effects Cobalt - metabolism glutamate In Vitro Techniques Larva Metamorphosis, Biological Neurons - drug effects Neurons - metabolism Pigments, Biological Quinoxalines - pharmacology Rana esculenta Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - metabolism Receptors, Kainic Acid - antagonists & inhibitors Receptors, Kainic Acid - metabolism Spinal Cord - cytology Spinal Cord - drug effects Spinal Cord - metabolism α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors |
| title | AMPA/kainate receptors permeable to divalent cations in amphibian central nervous system |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T15%3A10%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=AMPA/kainate%20receptors%20permeable%20to%20divalent%20cations%20in%20amphibian%20central%20nervous%20system&rft.jtitle=Life%20sciences%20(1973)&rft.au=Estabel,%20Jeanne&rft.date=1999&rft.volume=64&rft.issue=8&rft.spage=607&rft.epage=616&rft.pages=607-616&rft.issn=0024-3205&rft.eissn=1879-0631&rft_id=info:doi/10.1016/S0024-3205(98)00603-1&rft_dat=%3Cproquest_cross%3E17576701%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17576701&rft_id=info:pmid/10069524&rft_els_id=S0024320598006031&rfr_iscdi=true |