Discovery and Development of Donepezil Hydrochloride for the Treatment of Alzheimer's Disease

The most consistent change of neurotransmitter in the brain of Alzheimer's patients is the dramatic decrease of cholinergic innervation due to the loss of neurons in the basal forebrain. The most widely studied acetylcholinesterase inhibitors (AChEIs) have been physostigmine and tacrine. Physos...

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Veröffentlicht in:	YAKUGAKU ZASSHI 1999/02/01, Vol.119(2), pp.101-113
Hauptverfasser:	SUGIMOTO, Hachiro, YAMANISHI, Yoshiharu, OGURA, Hiroo, IIMURA, Youichi, YAMATSU, Kiyomi
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	acetylcholine Acetylcholine - physiology acetylcholinesterase Alzheimer Disease - drug therapy Alzheimer Disease - etiology Alzheimer's disease Animals choline hypothesis Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - pharmacology Cholinesterase Inhibitors - therapeutic use Clinical Trials as Topic Donepezil donepezil hydrochloride Drug Design E2020 Humans Indans - chemical synthesis Indans - pharmacology Indans - therapeutic use Piperidines - chemical synthesis Piperidines - pharmacology Piperidines - therapeutic use Rats Receptors, Cholinergic - physiology Structure-Activity Relationship
Online-Zugang:	Volltext
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