Development of muscarinic receptors and regulation of secretory responsiveness in rodent sweat glands
Sweat glands are innervated by sympathetic neurons which undergo a change in transmitter phenotype from noradrenergic to cholinergic during development. As soon as the glands begin to differentiate, M3 muscarinic receptor mRNA and binding sites are detectable. Receptor expression appears in the abse...
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| Veröffentlicht in: | Life sciences (1973) 1999, Vol.64 (6), p.381-385 |
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| container_title | Life sciences (1973) |
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| creator | Landis, Story C. |
| description | Sweat glands are innervated by sympathetic neurons which undergo a change in transmitter phenotype from noradrenergic to cholinergic during development. As soon as the glands begin to differentiate, M3 muscarinic receptor mRNA and binding sites are detectable. Receptor expression appears in the absence of innervation and is maintained after denervation. While receptor expression is not regulated by innervation, secretory responsiveness is. Muscarinic blockade during development or in adult animals results in the loss of responsiveness and its reappearance requires several days. Cholinergic muscarinic activation is most likely to regulate one or more steps in the signalling cascade that are downstream of calcium mobilization. The anterograde regulation of sweat gland responsiveness is one facet of the reciprocal interactions are required to establish a functional synapse in this system. |
| doi_str_mv | 10.1016/S0024-3205(98)00578-5 |
| format | Article |
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As soon as the glands begin to differentiate, M3 muscarinic receptor mRNA and binding sites are detectable. Receptor expression appears in the absence of innervation and is maintained after denervation. While receptor expression is not regulated by innervation, secretory responsiveness is. Muscarinic blockade during development or in adult animals results in the loss of responsiveness and its reappearance requires several days. Cholinergic muscarinic activation is most likely to regulate one or more steps in the signalling cascade that are downstream of calcium mobilization. The anterograde regulation of sweat gland responsiveness is one facet of the reciprocal interactions are required to establish a functional synapse in this system.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(98)00578-5</identifier><identifier>PMID: 10069500</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Acetylcholine - metabolism ; Animals ; Cell Differentiation ; Muscarinic Antagonists - pharmacology ; Rats ; Receptors, Muscarinic - metabolism ; Signal Transduction ; sweat gland secretion ; Sweat Glands - drug effects ; Sweat Glands - growth & development ; Sweat Glands - innervation ; Sweat Glands - metabolism ; Sweat Glands - physiology ; sympathetic innervation ; transmitter plasticity</subject><ispartof>Life sciences (1973), 1999, Vol.64 (6), p.381-385</ispartof><rights>1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-8f3d0dc8baac4cbf99ca19a5272ed68b689247fbb0e3dbeb285ed02adb6b7b9d3</citedby><cites>FETCH-LOGICAL-c361t-8f3d0dc8baac4cbf99ca19a5272ed68b689247fbb0e3dbeb285ed02adb6b7b9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0024-3205(98)00578-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10069500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Landis, Story C.</creatorcontrib><title>Development of muscarinic receptors and regulation of secretory responsiveness in rodent sweat glands</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Sweat glands are innervated by sympathetic neurons which undergo a change in transmitter phenotype from noradrenergic to cholinergic during development. As soon as the glands begin to differentiate, M3 muscarinic receptor mRNA and binding sites are detectable. Receptor expression appears in the absence of innervation and is maintained after denervation. While receptor expression is not regulated by innervation, secretory responsiveness is. Muscarinic blockade during development or in adult animals results in the loss of responsiveness and its reappearance requires several days. Cholinergic muscarinic activation is most likely to regulate one or more steps in the signalling cascade that are downstream of calcium mobilization. The anterograde regulation of sweat gland responsiveness is one facet of the reciprocal interactions are required to establish a functional synapse in this system.</description><subject>Acetylcholine - metabolism</subject><subject>Animals</subject><subject>Cell Differentiation</subject><subject>Muscarinic Antagonists - pharmacology</subject><subject>Rats</subject><subject>Receptors, Muscarinic - metabolism</subject><subject>Signal Transduction</subject><subject>sweat gland secretion</subject><subject>Sweat Glands - drug effects</subject><subject>Sweat Glands - growth & development</subject><subject>Sweat Glands - innervation</subject><subject>Sweat Glands - metabolism</subject><subject>Sweat Glands - physiology</subject><subject>sympathetic innervation</subject><subject>transmitter plasticity</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EotvCTwDlhOghMHbWjn1CVfmUKnEAzpY_JpVREgdPsqj_Hm-3Qtw4WWM_74znYewFhzccuHr7DUDs206AfG30JYDsdSsfsR3XvWlBdfwx2_1Fztg50U-olOy7p-yMAygjAXYM3-MBx7xMOK9NHpppo-BKmlNoCgZc1lyocXOs1e02ujXl-YgRhoL17a7e05JnSgeckahJc1NyPDaj3-jW5nasYXrGngxuJHz-cF6wHx8_fL_-3N58_fTl-uqmDZ3ia6uHLkIM2jsX9sEPxgTHjZOiFxiV9kobse8H7wG76NELLTGCcNEr33sTuwv26tR3KfnXhrTaKVHAsX4C80ZWGQUGhKigPIGhZKKCg11Kmly5sxzs0a-992uP8qzR9t6vlTX38mHA5ieM_6ROQivw7gRgXfOQsFgKCeeAMVWfq405_WfEH9ptjgs</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Landis, Story C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Development of muscarinic receptors and regulation of secretory responsiveness in rodent sweat glands</title><author>Landis, Story C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-8f3d0dc8baac4cbf99ca19a5272ed68b689247fbb0e3dbeb285ed02adb6b7b9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acetylcholine - metabolism</topic><topic>Animals</topic><topic>Cell Differentiation</topic><topic>Muscarinic Antagonists - pharmacology</topic><topic>Rats</topic><topic>Receptors, Muscarinic - metabolism</topic><topic>Signal Transduction</topic><topic>sweat gland secretion</topic><topic>Sweat Glands - drug effects</topic><topic>Sweat Glands - growth & development</topic><topic>Sweat Glands - innervation</topic><topic>Sweat Glands - metabolism</topic><topic>Sweat Glands - physiology</topic><topic>sympathetic innervation</topic><topic>transmitter plasticity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Landis, Story C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Landis, Story C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of muscarinic receptors and regulation of secretory responsiveness in rodent sweat glands</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1999</date><risdate>1999</risdate><volume>64</volume><issue>6</issue><spage>381</spage><epage>385</epage><pages>381-385</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Sweat glands are innervated by sympathetic neurons which undergo a change in transmitter phenotype from noradrenergic to cholinergic during development. As soon as the glands begin to differentiate, M3 muscarinic receptor mRNA and binding sites are detectable. Receptor expression appears in the absence of innervation and is maintained after denervation. While receptor expression is not regulated by innervation, secretory responsiveness is. Muscarinic blockade during development or in adult animals results in the loss of responsiveness and its reappearance requires several days. Cholinergic muscarinic activation is most likely to regulate one or more steps in the signalling cascade that are downstream of calcium mobilization. The anterograde regulation of sweat gland responsiveness is one facet of the reciprocal interactions are required to establish a functional synapse in this system.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>10069500</pmid><doi>10.1016/S0024-3205(98)00578-5</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Life sciences (1973), 1999, Vol.64 (6), p.381-385 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acetylcholine - metabolism Animals Cell Differentiation Muscarinic Antagonists - pharmacology Rats Receptors, Muscarinic - metabolism Signal Transduction sweat gland secretion Sweat Glands - drug effects Sweat Glands - growth & development Sweat Glands - innervation Sweat Glands - metabolism Sweat Glands - physiology sympathetic innervation transmitter plasticity |
| title | Development of muscarinic receptors and regulation of secretory responsiveness in rodent sweat glands |
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