Matrix Metalloproteinase-3 Enhances the Free Fatty Acids-Induced VEGF Expression in Adipocytes Through Toll-Like Receptor 2

Infiltrated macrophages (Mϕ) are believed to cause pathological changes in the surrounding adipocytes through the secretion of active molecules in visceral fat. Matrix metalloproteinase (MMP)-3 is secreted from Mϕ, and enhances expression of the inflammatory cytokines through the activation of toll-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2008-10, Vol.233 (10), p.1213-1221
Hauptverfasser:	Kawamura, Toru, Murakami, Kentaro, Bujo, Hideaki, Unoki, Hiroyuki, Jiang, Meizi, Nakayama, Toshinori, Saito, Yasushi
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes - cytology Adipocytes - drug effects Adipocytes - metabolism Animals Antibodies - pharmacology Culture Media, Conditioned - pharmacology Fatty Acids, Nonesterified - physiology Intra-Abdominal Fat - drug effects Intra-Abdominal Fat - metabolism Macrophages - cytology Macrophages - metabolism Matrix Metalloproteinase 3 - physiology Mice Mice, Inbred C57BL Mice, Knockout RNA, Messenger - metabolism RNA, Small Interfering - pharmacology Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Tumor Necrosis Factor-alpha - immunology Vascular Endothelial Growth Factor A - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!