Migraine and Antiphospholipid Antibodies: No Association Found in Migraine-Discordant Monozygotic Twins
Migraine headache (with and without aura) is common in the general population and is known to be influenced by genetic factors with heritability estimates between 34-57±. Antiphospholipid syndrome (APS) is a hypercoagulable state characterized by clinical features including venous and arterial throm...
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| Veröffentlicht in: | Cephalalgia 2008-10, Vol.28 (10), p.1048-1052 |
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| creator | Williams, FMK Cherkas, LF Bertolaccini, ML Murru, V Surdulescu, GL Hughes, GRV Khamashta, MA Spector, TD MacGregor, AJ |
| description | Migraine headache (with and without aura) is common in the general population and is known to be influenced by genetic factors with heritability estimates between 34-57±. Antiphospholipid syndrome (APS) is a hypercoagulable state characterized by clinical features including venous and arterial thromboses, pregnancy loss and migraine, and by association with antiphospholipid antibodies (aPL). Numerous small studies have investigated whether aPL are associated with migraine in the general population—-with contradictory results. In this study, the question was addressed by studying the prevalence of aPL in members of monozygotic (MZ) twin pairs differing in their migraine status. Such twins provide a unique natural experiment, matched as they are for age, sex and genetic factors, and allow the role of environmental factors, such as aPL, to be determined. Despite 95± power to detect a difference of 0.59 IgG units per litre in anticardiolipin antibody IgG titres, no difference in prevalence of aPL could be detected in migraine-discordant MZ twins. |
| doi_str_mv | 10.1111/j.1468-2982.2008.01646.x |
| format | Article |
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Antiphospholipid syndrome (APS) is a hypercoagulable state characterized by clinical features including venous and arterial thromboses, pregnancy loss and migraine, and by association with antiphospholipid antibodies (aPL). Numerous small studies have investigated whether aPL are associated with migraine in the general population—-with contradictory results. In this study, the question was addressed by studying the prevalence of aPL in members of monozygotic (MZ) twin pairs differing in their migraine status. Such twins provide a unique natural experiment, matched as they are for age, sex and genetic factors, and allow the role of environmental factors, such as aPL, to be determined. Despite 95± power to detect a difference of 0.59 IgG units per litre in anticardiolipin antibody IgG titres, no difference in prevalence of aPL could be detected in migraine-discordant MZ twins.</description><identifier>ISSN: 0333-1024</identifier><identifier>EISSN: 1468-2982</identifier><identifier>DOI: 10.1111/j.1468-2982.2008.01646.x</identifier><identifier>PMID: 18624800</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antibodies, Anticardiolipin - blood ; anticardiolipin ; antiphospholipid ; beta 2-Glycoprotein I - immunology ; Female ; Humans ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; Lipoproteins, LDL - immunology ; Male ; Middle Aged ; Migraine ; Migraine Disorders - epidemiology ; Migraine Disorders - genetics ; Migraine Disorders - immunology ; monozygotic ; Prevalence ; Seroepidemiologic Studies ; twin ; Twins, Monozygotic</subject><ispartof>Cephalalgia, 2008-10, Vol.28 (10), p.1048-1052</ispartof><rights>2008 International Headache Society</rights><rights>Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4956-5dc8a2c2b6ebbf71a3d9aeca6db52b05449a5c558bddb82c102f4b05a29d30703</citedby><cites>FETCH-LOGICAL-c4956-5dc8a2c2b6ebbf71a3d9aeca6db52b05449a5c558bddb82c102f4b05a29d30703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1111/j.1468-2982.2008.01646.x$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1111/j.1468-2982.2008.01646.x$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,21971,27858,27929,27930,43626,43627,44950,45338</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1111/j.1468-2982.2008.01646.x?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18624800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, FMK</creatorcontrib><creatorcontrib>Cherkas, LF</creatorcontrib><creatorcontrib>Bertolaccini, ML</creatorcontrib><creatorcontrib>Murru, V</creatorcontrib><creatorcontrib>Surdulescu, GL</creatorcontrib><creatorcontrib>Hughes, GRV</creatorcontrib><creatorcontrib>Khamashta, MA</creatorcontrib><creatorcontrib>Spector, TD</creatorcontrib><creatorcontrib>MacGregor, AJ</creatorcontrib><title>Migraine and Antiphospholipid Antibodies: No Association Found in Migraine-Discordant Monozygotic Twins</title><title>Cephalalgia</title><addtitle>Cephalalgia</addtitle><description>Migraine headache (with and without aura) is common in the general population and is known to be influenced by genetic factors with heritability estimates between 34-57±. Antiphospholipid syndrome (APS) is a hypercoagulable state characterized by clinical features including venous and arterial thromboses, pregnancy loss and migraine, and by association with antiphospholipid antibodies (aPL). Numerous small studies have investigated whether aPL are associated with migraine in the general population—-with contradictory results. In this study, the question was addressed by studying the prevalence of aPL in members of monozygotic (MZ) twin pairs differing in their migraine status. Such twins provide a unique natural experiment, matched as they are for age, sex and genetic factors, and allow the role of environmental factors, such as aPL, to be determined. Despite 95± power to detect a difference of 0.59 IgG units per litre in anticardiolipin antibody IgG titres, no difference in prevalence of aPL could be detected in migraine-discordant MZ twins.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Anticardiolipin - blood</subject><subject>anticardiolipin</subject><subject>antiphospholipid</subject><subject>beta 2-Glycoprotein I - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M - blood</subject><subject>Lipoproteins, LDL - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Migraine</subject><subject>Migraine Disorders - epidemiology</subject><subject>Migraine Disorders - genetics</subject><subject>Migraine Disorders - immunology</subject><subject>monozygotic</subject><subject>Prevalence</subject><subject>Seroepidemiologic Studies</subject><subject>twin</subject><subject>Twins, Monozygotic</subject><issn>0333-1024</issn><issn>1468-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUU1vEzEUtBCIhsJfQD5x2-XZazteDkhRaGmlFjiUs-WvBEcbO6x31YZfj7cb4FgsWX56nhk_zyCECdSkrPe7mjAhK9pKWlMAWQMRTNQPz9Di78VztICmaSoClJ2hVznvAIALEC_RGZGCMgmwQNvbsO11iB7r6PAqDuHwI-Wyu3AIc8MkF3z-gL8kvMo52aCHkCK-TGNhhIj_KFSfQrapdzoO-DbF9Ou4TUOw-O4-xPwavdjoLvs3p_Mcfb-8uFtfVTdfP1-vVzeVZS0XFXdWamqpEd6YzZLoxrXaWy2c4dQAZ6zV3HIujXNGUls-t2Glr2nrGlhCc47ezbqHPv0cfR7Uvkzlu05Hn8asRCtgKSl7EkiBNUtCaQHKGWj7lHPvN-rQh73uj4qAmtJQOzWZribT1ZSGekxDPRTq29Mbo9l79494sr8APs6A-9D5438Lq_XFt6upLAJ8Fsh669UujX0s7j492W_ADapQ</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Williams, FMK</creator><creator>Cherkas, LF</creator><creator>Bertolaccini, ML</creator><creator>Murru, V</creator><creator>Surdulescu, GL</creator><creator>Hughes, GRV</creator><creator>Khamashta, MA</creator><creator>Spector, TD</creator><creator>MacGregor, AJ</creator><general>SAGE Publications</general><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200810</creationdate><title>Migraine and Antiphospholipid Antibodies: No Association Found in Migraine-Discordant Monozygotic Twins</title><author>Williams, FMK ; Cherkas, LF ; Bertolaccini, ML ; Murru, V ; Surdulescu, GL ; Hughes, GRV ; Khamashta, MA ; Spector, TD ; MacGregor, AJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4956-5dc8a2c2b6ebbf71a3d9aeca6db52b05449a5c558bddb82c102f4b05a29d30703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies, Anticardiolipin - blood</topic><topic>anticardiolipin</topic><topic>antiphospholipid</topic><topic>beta 2-Glycoprotein I - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin M - blood</topic><topic>Lipoproteins, LDL - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Migraine</topic><topic>Migraine Disorders - epidemiology</topic><topic>Migraine Disorders - genetics</topic><topic>Migraine Disorders - immunology</topic><topic>monozygotic</topic><topic>Prevalence</topic><topic>Seroepidemiologic Studies</topic><topic>twin</topic><topic>Twins, Monozygotic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, FMK</creatorcontrib><creatorcontrib>Cherkas, LF</creatorcontrib><creatorcontrib>Bertolaccini, ML</creatorcontrib><creatorcontrib>Murru, V</creatorcontrib><creatorcontrib>Surdulescu, GL</creatorcontrib><creatorcontrib>Hughes, GRV</creatorcontrib><creatorcontrib>Khamashta, MA</creatorcontrib><creatorcontrib>Spector, TD</creatorcontrib><creatorcontrib>MacGregor, AJ</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cephalalgia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Williams, FMK</au><au>Cherkas, LF</au><au>Bertolaccini, ML</au><au>Murru, V</au><au>Surdulescu, GL</au><au>Hughes, GRV</au><au>Khamashta, MA</au><au>Spector, TD</au><au>MacGregor, AJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Migraine and Antiphospholipid Antibodies: No Association Found in Migraine-Discordant Monozygotic Twins</atitle><jtitle>Cephalalgia</jtitle><addtitle>Cephalalgia</addtitle><date>2008-10</date><risdate>2008</risdate><volume>28</volume><issue>10</issue><spage>1048</spage><epage>1052</epage><pages>1048-1052</pages><issn>0333-1024</issn><eissn>1468-2982</eissn><abstract>Migraine headache (with and without aura) is common in the general population and is known to be influenced by genetic factors with heritability estimates between 34-57±. Antiphospholipid syndrome (APS) is a hypercoagulable state characterized by clinical features including venous and arterial thromboses, pregnancy loss and migraine, and by association with antiphospholipid antibodies (aPL). Numerous small studies have investigated whether aPL are associated with migraine in the general population—-with contradictory results. In this study, the question was addressed by studying the prevalence of aPL in members of monozygotic (MZ) twin pairs differing in their migraine status. Such twins provide a unique natural experiment, matched as they are for age, sex and genetic factors, and allow the role of environmental factors, such as aPL, to be determined. 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| subjects | Adult Aged Aged, 80 and over Antibodies, Anticardiolipin - blood anticardiolipin antiphospholipid beta 2-Glycoprotein I - immunology Female Humans Immunoglobulin G - blood Immunoglobulin M - blood Lipoproteins, LDL - immunology Male Middle Aged Migraine Migraine Disorders - epidemiology Migraine Disorders - genetics Migraine Disorders - immunology monozygotic Prevalence Seroepidemiologic Studies twin Twins, Monozygotic |
| title | Migraine and Antiphospholipid Antibodies: No Association Found in Migraine-Discordant Monozygotic Twins |
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