Regulation and transfer of a murine model of thyrotropin receptor antibody mediated Graves' disease

In order to replicate a recently described murine model of Graves' disease, we immunized AKR/N (H-2k) mice i.p., every 2 weeks, with either a clone of fibroblasts expressing both the human TSH receptor (hTSHR) and murine major histocompatibility complex (MHC) class II molecules or with fibrobla...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1999-03, Vol.140 (3), p.1392-1398
Hauptverfasser:	Kita, M, Ahmad, L, Marians, R C, Vlase, H, Unger, P, Graves, P N, Davies, T F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation Disease Models, Animal DNA, Complementary - genetics Female Graves Disease - immunology Histocompatibility Antigens Class II - immunology Humans Immunization L Cells (Cell Line) Male Mice Receptors, Thyrotropin - immunology Thyroid Function Tests Transfection
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