ACTIVATION OF VASCULAR SMOOTH MUSCLE K+ CHANNELS BY ENDOTHELIUM-DERIVED RELAXING FACTORS

1. Endothelium‐derived relaxing factors (EDRF), including nitric oxide (NO), prostacyclin (PGI2) and an as yet uncharacterized endothelium‐derived hyperpolarizing factor (EDHF), are now recognized to induce relaxation of vascular smooth muscle, in part via the activation of K+ channels. 2. Experimen...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 1999-02, Vol.26 (2), p.180-184
Hauptverfasser:	Waldron, GJ, Cole, WC
Format:	Artikel
Sprache:	eng
Schlagworte:	4-aminopyridine Animals apamin charybdotoxin endothelium- derived relaxing factors endothelium-derived hyperpolarizing factor glibenclamide iberiotoxin Ion Channels - metabolism K+ channels Muscle, Smooth, Vascular - metabolism nitric oxide Nitric Oxide - metabolism Potassium Channels - metabolism prostacyclin Species Specificity Tissue Distribution vascular smooth muscle Vasodilation
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