Impaired Counterregulation of Glucose in a Patient with Hypothalamic Sarcoidosis
Hypoglycemia stimulates rapid increases in the secretion of several hormones, including catecholamines, glucagon, cortisol, and growth hormone, that act in concert to increase the plasma glucose concentration. The chief role of the central nervous system in triggering the release of such counterregu...
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| Veröffentlicht in: | The New England journal of medicine 1999-03, Vol.340 (11), p.852-856 |
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| creator | Féry, Françoise Plat, Laurence van de Borne, Philippe Cogan, Elie Mockel, Jean |
| description | Hypoglycemia stimulates rapid increases in the secretion of several hormones, including catecholamines, glucagon, cortisol, and growth hormone, that act in concert to increase the plasma glucose concentration. The chief role of the central nervous system in triggering the release of such counterregulatory hormones during hypoglycemia is well recognized. The specific region of the hypothalamus responsible for this process is probably the ventromedial region, because bilateral lesions or perfusion of d-glucose into this region reduces the increases in plasma glucagon and catecholamines in response to hypoglycemia in rats.
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We describe a patient with a hypothalamic sarcoid infiltrate who had complete . . . |
| doi_str_mv | 10.1056/NEJM199903183401105 |
| format | Article |
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We describe a patient with a hypothalamic sarcoid infiltrate who had complete . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199903183401105</identifier><identifier>PMID: 10080848</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - metabolism ; Case studies ; Catecholamines - blood ; Female ; Glucagon - blood ; Glucose ; Homeostasis ; Human Growth Hormone - blood ; Humans ; Hydrocortisone - blood ; Hypoglycemia ; Hypoglycemia - metabolism ; Hypothalamic Diseases - metabolism ; Medical diagnosis ; Medical sciences ; Patients ; Sarcoidosis - metabolism ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><ispartof>The New England journal of medicine, 1999-03, Vol.340 (11), p.852-856</ispartof><rights>Copyright © 1999 Massachusetts Medical Society. All rights reserved.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-d0aa220f2cbac0a82ea9d5e64e15b77cc8329e84452ea7b647a7a8842a1709c93</citedby><cites>FETCH-LOGICAL-c527t-d0aa220f2cbac0a82ea9d5e64e15b77cc8329e84452ea7b647a7a8842a1709c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199903183401105$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223939863?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1712398$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10080848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Féry, Françoise</creatorcontrib><creatorcontrib>Plat, Laurence</creatorcontrib><creatorcontrib>van de Borne, Philippe</creatorcontrib><creatorcontrib>Cogan, Elie</creatorcontrib><creatorcontrib>Mockel, Jean</creatorcontrib><title>Impaired Counterregulation of Glucose in a Patient with Hypothalamic Sarcoidosis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Hypoglycemia stimulates rapid increases in the secretion of several hormones, including catecholamines, glucagon, cortisol, and growth hormone, that act in concert to increase the plasma glucose concentration. The chief role of the central nervous system in triggering the release of such counterregulatory hormones during hypoglycemia is well recognized. The specific region of the hypothalamus responsible for this process is probably the ventromedial region, because bilateral lesions or perfusion of d-glucose into this region reduces the increases in plasma glucagon and catecholamines in response to hypoglycemia in rats.
1
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We describe a patient with a hypothalamic sarcoid infiltrate who had complete . . .</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Case studies</subject><subject>Catecholamines - blood</subject><subject>Female</subject><subject>Glucagon - blood</subject><subject>Glucose</subject><subject>Homeostasis</subject><subject>Human Growth Hormone - blood</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Hypoglycemia</subject><subject>Hypoglycemia - metabolism</subject><subject>Hypothalamic Diseases - metabolism</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Patients</subject><subject>Sarcoidosis - metabolism</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp90Ntq3DAQBmBRGppN0icoFFFKboKT0cGWdFmWHEnahbbXZlaWGy22tZFsQt4-WnahIYToRjD6ZjT8hHxhcMqgrM5-nt_cMWMMCKaFBJaLH8iMlUIUUkL1kcwAuC6kMmKfHKS0gnyYNJ_IPgPQoKWekcV1v0YfXUPnYRpGF6P7N3U4-jDQ0NLLbrIhOeoHinSRy24Y6aMf7-nV0zqM99hh7y39jdEG34Tk0xHZa7FL7vPuPiR_L87_zK-K21-X1_Mft4UtuRqLBhA5h5bbJVpAzR2apnSVdKxcKmWtFtw4LWWZX9SykgoVai05MgXGGnFIjrdz1zE8TC6Nde-TdV2HgwtTqitTQcU1y_DbK7gKUxzybjXnwgijK5GR2CIbQ0rRtfU6-h7jU82g3qRdv5F27vq6Gz0te9e86NnGm8H3HcBksWsjDtan_06xvMGGnWxZ36d6cKv-3V-fAZ__kqU</recordid><startdate>19990318</startdate><enddate>19990318</enddate><creator>Féry, Françoise</creator><creator>Plat, Laurence</creator><creator>van de Borne, Philippe</creator><creator>Cogan, Elie</creator><creator>Mockel, Jean</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19990318</creationdate><title>Impaired Counterregulation of Glucose in a Patient with Hypothalamic Sarcoidosis</title><author>Féry, Françoise ; Plat, Laurence ; van de Borne, Philippe ; Cogan, Elie ; Mockel, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-d0aa220f2cbac0a82ea9d5e64e15b77cc8329e84452ea7b647a7a8842a1709c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Case studies</topic><topic>Catecholamines - blood</topic><topic>Female</topic><topic>Glucagon - blood</topic><topic>Glucose</topic><topic>Homeostasis</topic><topic>Human Growth Hormone - blood</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Hypoglycemia</topic><topic>Hypoglycemia - metabolism</topic><topic>Hypothalamic Diseases - metabolism</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Patients</topic><topic>Sarcoidosis - metabolism</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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The chief role of the central nervous system in triggering the release of such counterregulatory hormones during hypoglycemia is well recognized. The specific region of the hypothalamus responsible for this process is probably the ventromedial region, because bilateral lesions or perfusion of d-glucose into this region reduces the increases in plasma glucagon and catecholamines in response to hypoglycemia in rats.
1
,
2
We describe a patient with a hypothalamic sarcoid infiltrate who had complete . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>10080848</pmid><doi>10.1056/NEJM199903183401105</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adult Biological and medical sciences Blood Glucose - metabolism Case studies Catecholamines - blood Female Glucagon - blood Glucose Homeostasis Human Growth Hormone - blood Humans Hydrocortisone - blood Hypoglycemia Hypoglycemia - metabolism Hypothalamic Diseases - metabolism Medical diagnosis Medical sciences Patients Sarcoidosis - metabolism Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis |
| title | Impaired Counterregulation of Glucose in a Patient with Hypothalamic Sarcoidosis |
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