Plexiform angiomyxoid myofibroblastic tumour: differential diagnosis of gastrointestinal stromal tumour in the stomach
Mesenchymal tumours other than gastrointestinal stromal tumours are rare in the stomach. Nevertheless it is important to incorporate them into the differential diagnosis. Plexiform angiomyxoid myofibroblastic tumour is a recently described new entity of a presumably benign mesenchymal gastric tumour...
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| Veröffentlicht in: | Journal of clinical pathology 2008-10, Vol.61 (10), p.1136-1137 |
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| creator | Rau, T T Hartmann, A Dietmaier, W Schmitz, J Hohenberger, W Hofstaedter, F Katenkamp, K |
| description | Mesenchymal tumours other than gastrointestinal stromal tumours are rare in the stomach. Nevertheless it is important to incorporate them into the differential diagnosis. Plexiform angiomyxoid myofibroblastic tumour is a recently described new entity of a presumably benign mesenchymal gastric tumour. This report presents what is believed to be the third case of this tumour. The tumour is characterised by bland spindle cells in a plexiform pattern, a mucinous extracellular matrix and a network of thin blood vessels. These findings are completely in line with the two previous reported cases. There was a strong positivity for α-smooth muscle actin and a low proliferation index ( |
| doi_str_mv | 10.1136/jcp.2008.059162 |
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Nevertheless it is important to incorporate them into the differential diagnosis. Plexiform angiomyxoid myofibroblastic tumour is a recently described new entity of a presumably benign mesenchymal gastric tumour. This report presents what is believed to be the third case of this tumour. The tumour is characterised by bland spindle cells in a plexiform pattern, a mucinous extracellular matrix and a network of thin blood vessels. These findings are completely in line with the two previous reported cases. There was a strong positivity for α-smooth muscle actin and a low proliferation index (<2%). The tumour had no C-KIT or CD34 expression and no mutation in the C-KIT and PDFGRα genes. Plexiform angiomyxoid myofibroblastic tumour may present a new mesenchymal tumour entity in the stomach.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.2008.059162</identifier><identifier>PMID: 18820104</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Biological and medical sciences ; Diagnosis, Differential ; DNA Mutational Analysis ; Extracellular matrix ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal Stromal Tumors - pathology ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Mesenchymoma - pathology ; Mesenchymoma - surgery ; Middle Aged ; Mutation ; Myofibroma - pathology ; Myxoma - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Smooth muscle ; Stomach ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Journal of clinical pathology, 2008-10, Vol.61 (10), p.1136-1137</ispartof><rights>2008 The BMJ Publishing Group and the Association of Clinical Pathologists</rights><rights>2008 INIST-CNRS</rights><rights>Copyright: 2008 2008 The BMJ Publishing Group and the Association of Clinical Pathologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b426t-84fbf148265b683df7bf364bd00fbb7e43aba1dc0265eb93b471cbc77ff58f753</citedby><cites>FETCH-LOGICAL-b426t-84fbf148265b683df7bf364bd00fbb7e43aba1dc0265eb93b471cbc77ff58f753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jcp.bmj.com/content/61/10/1136.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jcp.bmj.com/content/61/10/1136.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3182,23551,27903,27904,77347,77378</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20664676$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18820104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rau, T T</creatorcontrib><creatorcontrib>Hartmann, A</creatorcontrib><creatorcontrib>Dietmaier, W</creatorcontrib><creatorcontrib>Schmitz, J</creatorcontrib><creatorcontrib>Hohenberger, W</creatorcontrib><creatorcontrib>Hofstaedter, F</creatorcontrib><creatorcontrib>Katenkamp, K</creatorcontrib><title>Plexiform angiomyxoid myofibroblastic tumour: differential diagnosis of gastrointestinal stromal tumour in the stomach</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>Mesenchymal tumours other than gastrointestinal stromal tumours are rare in the stomach. Nevertheless it is important to incorporate them into the differential diagnosis. Plexiform angiomyxoid myofibroblastic tumour is a recently described new entity of a presumably benign mesenchymal gastric tumour. This report presents what is believed to be the third case of this tumour. The tumour is characterised by bland spindle cells in a plexiform pattern, a mucinous extracellular matrix and a network of thin blood vessels. These findings are completely in line with the two previous reported cases. There was a strong positivity for α-smooth muscle actin and a low proliferation index (<2%). The tumour had no C-KIT or CD34 expression and no mutation in the C-KIT and PDFGRα genes. Plexiform angiomyxoid myofibroblastic tumour may present a new mesenchymal tumour entity in the stomach.</description><subject>Biological and medical sciences</subject><subject>Diagnosis, Differential</subject><subject>DNA Mutational Analysis</subject><subject>Extracellular matrix</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal Stromal Tumors - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Mesenchymoma - pathology</subject><subject>Mesenchymoma - surgery</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Myofibroma - pathology</subject><subject>Myxoma - pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Smooth muscle</subject><subject>Stomach</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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| subjects | Biological and medical sciences Diagnosis, Differential DNA Mutational Analysis Extracellular matrix Female Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Stromal Tumors - pathology Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mesenchymoma - pathology Mesenchymoma - surgery Middle Aged Mutation Myofibroma - pathology Myxoma - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Smooth muscle Stomach Stomach Neoplasms - pathology Stomach Neoplasms - surgery Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Plexiform angiomyxoid myofibroblastic tumour: differential diagnosis of gastrointestinal stromal tumour in the stomach |
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