Up-regulation by human recombinant transforming growth factor β-1 of collagen production in cultured dermal fibroblasts is mediated by the inhibition of nitric oxide signaling

Background: Hypertrophic scarring remains the most disabling sequela for burn survivors. Little is known about its pathogenesis. Collagen accumulation, however, has been consistently observed in burn hypertrophic scars (HS). Study Design: We have studied collagen production in the dermal fibroblasts...

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Veröffentlicht in:	Journal of the American College of Surgeons 1999-03, Vol.188 (3), p.271-280
Hauptverfasser:	Chu, ArthurJ, Prasad, JaiK
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Burns Burns - complications Burns - metabolism Cells, Cultured Cicatrix - metabolism Cicatrix - pathology Collagen - biosynthesis Cyclic GMP - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Humans Linear Models Medical sciences Microscopy, Fluorescence NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - antagonists & inhibitors Nitric Oxide - metabolism Nitroprusside - pharmacology Proline - metabolism Signal Transduction - drug effects Transforming Growth Factor beta - metabolism Traumas. Diseases due to physical agents Up-Regulation
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