Mitochondria-cytochrome C -caspase-9 cascade mediates isorhamnetin-induced apoptosis

Abstract Isorhamnetin is a flavanoid present in plants of the Polygonaceae family and is also an immediate metabolite of quercetin in mammals. Since the plasma level of isorhamnetin is maintained longer than quercetin, isorhamnetin may be a key metabolite to mediate the anti-tumor effect of querceti...

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Veröffentlicht in:	Cancer letters 2008-11, Vol.270 (2), p.342-353
Hauptverfasser:	Lee, Hyo-Jung, Lee, Hyo-Jeong, Lee, Eun-Ok, Ko, Seong-Gyu, Bae, Hyun-Soo, Kim, Cheol-Ho, Ahn, Kyoo-Seok, Lu, Junxuan, Kim, Sung-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Cancer therapies Carcinoma, Lewis Lung - drug therapy Carcinoma, Lewis Lung - enzymology Carcinoma, Lewis Lung - pathology Caspase 9 - metabolism Caspase Inhibitors Caspases Cell culture Cell Line, Tumor Cell Proliferation - drug effects Cysteine Proteinase Inhibitors - pharmacology Cytochromes c - metabolism Deoxyribonucleic acid DNA Dose-Response Relationship, Drug Drug dosages Female Flavonols - administration & dosage Flavonols - pharmacology Hematology, Oncology and Palliative Medicine Injections, Intraperitoneal Isorhamnetin Membrane Potential, Mitochondrial - drug effects Mice Mice, Inbred C57BL Mitochondria Mitochondria - drug effects Mitochondria - enzymology Mitochondria - pathology Quercetin Quercetin - analogs & derivatives Studies Time Factors Tumors
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