Successful Medical Treatment of a Case of Paecilomyces lilacinus Keratitis
PURPOSE:To report a successful medical treatment of a case of keratitis caused by Paecilomyces lilacinus. METHODS:A 68-year-old woman developed an infection of the left cornea after minor trauma. The causative organism was found to be a particularly virulent organism, P. lilacinus. The patient was i...
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| Veröffentlicht in: | Cornea 2008-10, Vol.27 (9), p.1077-1079 |
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| container_title | Cornea |
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| creator | Ford, Jerry G Agee, Shawn Greenhaw, Steven T |
| description | PURPOSE:To report a successful medical treatment of a case of keratitis caused by Paecilomyces lilacinus.
METHODS:A 68-year-old woman developed an infection of the left cornea after minor trauma. The causative organism was found to be a particularly virulent organism, P. lilacinus. The patient was initially treated with natamycin topically and itraconazole orally, but the organism was resistant and failed to respond. She was then switched to topical voriconazole and oral terbinafine.
RESULTS:The patient was successfully treated with these medications without surgical intervention, an unusual outcome for this organism.
CONCLUSIONS:If one encounters a case of fungal keratitis that fails to respond to the more commonly used agents, one should suspect a resistant organism such as Paecilomyces and should switch to voriconazole and/or terbinafine both topically and orally. |
| doi_str_mv | 10.1097/ICO.0b013e3181783a07 |
| format | Article |
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METHODS:A 68-year-old woman developed an infection of the left cornea after minor trauma. The causative organism was found to be a particularly virulent organism, P. lilacinus. The patient was initially treated with natamycin topically and itraconazole orally, but the organism was resistant and failed to respond. She was then switched to topical voriconazole and oral terbinafine.
RESULTS:The patient was successfully treated with these medications without surgical intervention, an unusual outcome for this organism.
CONCLUSIONS:If one encounters a case of fungal keratitis that fails to respond to the more commonly used agents, one should suspect a resistant organism such as Paecilomyces and should switch to voriconazole and/or terbinafine both topically and orally.</description><identifier>ISSN: 0277-3740</identifier><identifier>EISSN: 1536-4798</identifier><identifier>DOI: 10.1097/ICO.0b013e3181783a07</identifier><identifier>PMID: 18812777</identifier><language>eng</language><publisher>United States: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Administration, Oral ; Administration, Topical ; Antifungal Agents - administration & dosage ; Antifungal Agents - therapeutic use ; Drug Resistance, Fungal ; Drug Therapy, Combination ; Eye Infections, Fungal - drug therapy ; Female ; Humans ; Keratitis - microbiology ; Middle Aged ; Naphthalenes - administration & dosage ; Naphthalenes - therapeutic use ; Paecilomyces - physiology ; Pyrimidines - administration & dosage ; Pyrimidines - therapeutic use ; Triazoles - administration & dosage ; Triazoles - therapeutic use ; Voriconazole</subject><ispartof>Cornea, 2008-10, Vol.27 (9), p.1077-1079</ispartof><rights>Copyright © 2008 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3502-976a291f9d335968d0913717d288a4da3f8d560d8d861f92d17d2c5de9002a263</citedby><cites>FETCH-LOGICAL-c3502-976a291f9d335968d0913717d288a4da3f8d560d8d861f92d17d2c5de9002a263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18812777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ford, Jerry G</creatorcontrib><creatorcontrib>Agee, Shawn</creatorcontrib><creatorcontrib>Greenhaw, Steven T</creatorcontrib><title>Successful Medical Treatment of a Case of Paecilomyces lilacinus Keratitis</title><title>Cornea</title><addtitle>Cornea</addtitle><description>PURPOSE:To report a successful medical treatment of a case of keratitis caused by Paecilomyces lilacinus.
METHODS:A 68-year-old woman developed an infection of the left cornea after minor trauma. The causative organism was found to be a particularly virulent organism, P. lilacinus. The patient was initially treated with natamycin topically and itraconazole orally, but the organism was resistant and failed to respond. She was then switched to topical voriconazole and oral terbinafine.
RESULTS:The patient was successfully treated with these medications without surgical intervention, an unusual outcome for this organism.
CONCLUSIONS:If one encounters a case of fungal keratitis that fails to respond to the more commonly used agents, one should suspect a resistant organism such as Paecilomyces and should switch to voriconazole and/or terbinafine both topically and orally.</description><subject>Administration, Oral</subject><subject>Administration, Topical</subject><subject>Antifungal Agents - administration & dosage</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Drug Resistance, Fungal</subject><subject>Drug Therapy, Combination</subject><subject>Eye Infections, Fungal - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Keratitis - microbiology</subject><subject>Middle Aged</subject><subject>Naphthalenes - administration & dosage</subject><subject>Naphthalenes - therapeutic use</subject><subject>Paecilomyces - physiology</subject><subject>Pyrimidines - administration & dosage</subject><subject>Pyrimidines - therapeutic use</subject><subject>Triazoles - administration & dosage</subject><subject>Triazoles - therapeutic use</subject><subject>Voriconazole</subject><issn>0277-3740</issn><issn>1536-4798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLAzEQx4MoWqvfQGRP3lYnSTePoxQf1YqC9RzSZBZXs11Ndin99qZYEDwMM8P_cfgRckbhkoKWV7Pp8yUsgXLkVFGpuAW5R0a04qKcSK32yQiYlCWXEzgixyl9AICUgh2SI6oUzZockYfXwTlMqR5C8YS-cTYUi4i2b3HVF11d2GJqE26vF4uuCV27yf4iNMG6ZjWk4hGj7Zu-SSfkoLYh4eluj8nb7c1iel_On-9m0-t56XgFrNRSWKZprT3nlRbKg6ZcUumZUnbiLa-VrwR45ZXILua3kqs8agBmmeBjcvHb-xW77wFTb9omOQzBrrAbkhFaQAaks3Hya3SxSylibb5i09q4MRTMlqHJDM1_hjl2vusfli36v9AO2l_vugs9xvQZhjVG84429O8mUwbOmCgZgKLbr8zDGP8Bqsd76Q</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Ford, Jerry G</creator><creator>Agee, Shawn</creator><creator>Greenhaw, Steven T</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200810</creationdate><title>Successful Medical Treatment of a Case of Paecilomyces lilacinus Keratitis</title><author>Ford, Jerry G ; Agee, Shawn ; Greenhaw, Steven T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3502-976a291f9d335968d0913717d288a4da3f8d560d8d861f92d17d2c5de9002a263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Administration, Oral</topic><topic>Administration, Topical</topic><topic>Antifungal Agents - administration & dosage</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Drug Resistance, Fungal</topic><topic>Drug Therapy, Combination</topic><topic>Eye Infections, Fungal - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Keratitis - microbiology</topic><topic>Middle Aged</topic><topic>Naphthalenes - administration & dosage</topic><topic>Naphthalenes - therapeutic use</topic><topic>Paecilomyces - physiology</topic><topic>Pyrimidines - administration & dosage</topic><topic>Pyrimidines - therapeutic use</topic><topic>Triazoles - administration & dosage</topic><topic>Triazoles - therapeutic use</topic><topic>Voriconazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ford, Jerry G</creatorcontrib><creatorcontrib>Agee, Shawn</creatorcontrib><creatorcontrib>Greenhaw, Steven T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cornea</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ford, Jerry G</au><au>Agee, Shawn</au><au>Greenhaw, Steven T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful Medical Treatment of a Case of Paecilomyces lilacinus Keratitis</atitle><jtitle>Cornea</jtitle><addtitle>Cornea</addtitle><date>2008-10</date><risdate>2008</risdate><volume>27</volume><issue>9</issue><spage>1077</spage><epage>1079</epage><pages>1077-1079</pages><issn>0277-3740</issn><eissn>1536-4798</eissn><abstract>PURPOSE:To report a successful medical treatment of a case of keratitis caused by Paecilomyces lilacinus.
METHODS:A 68-year-old woman developed an infection of the left cornea after minor trauma. The causative organism was found to be a particularly virulent organism, P. lilacinus. The patient was initially treated with natamycin topically and itraconazole orally, but the organism was resistant and failed to respond. She was then switched to topical voriconazole and oral terbinafine.
RESULTS:The patient was successfully treated with these medications without surgical intervention, an unusual outcome for this organism.
CONCLUSIONS:If one encounters a case of fungal keratitis that fails to respond to the more commonly used agents, one should suspect a resistant organism such as Paecilomyces and should switch to voriconazole and/or terbinafine both topically and orally.</abstract><cop>United States</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>18812777</pmid><doi>10.1097/ICO.0b013e3181783a07</doi><tpages>3</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Administration, Oral Administration, Topical Antifungal Agents - administration & dosage Antifungal Agents - therapeutic use Drug Resistance, Fungal Drug Therapy, Combination Eye Infections, Fungal - drug therapy Female Humans Keratitis - microbiology Middle Aged Naphthalenes - administration & dosage Naphthalenes - therapeutic use Paecilomyces - physiology Pyrimidines - administration & dosage Pyrimidines - therapeutic use Triazoles - administration & dosage Triazoles - therapeutic use Voriconazole |
| title | Successful Medical Treatment of a Case of Paecilomyces lilacinus Keratitis |
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