Phosphotyrosine-Containing Dipeptides as High-Affinity Ligands for the p56lck SH2 Domain

Src homology-2 (SH2) domains are noncatalytic motifs containing approximately 100 amino acid residues that are involved in intracellular signal transduction. The phosphotyrosine-containing tetrapeptide Ac-pYEEI binds to the SH2 domain of p56lck (Lck) with an affinity of 0.1 microM. Starting from Ac-...

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Veröffentlicht in:	Journal of medicinal chemistry 1999-02, Vol.42 (4), p.722-729
Hauptverfasser:	LLINàS-BRUNET, Montse, BEAULIEU, Pierre L., CAMERON, Dale R., FERLAND, Jean-Marie, GAUTHIER, Jean, GHIRO, Elise, GILLARD, James, GORYS, Vida, POIRIER, Martin, RANCOURT, Jean, WERNIC, Dominik, BETAGERI, Raj, CARDOZO, Mario, JAKES, Scott, LUKAS, Suzanne, PATEL, Usha, PROUDFOOT, John, MOSS, Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Binding, Competitive Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Dipeptides - chemical synthesis Dipeptides - chemistry Dipeptides - metabolism Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism General aspects Ligands Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - antagonists & inhibitors Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Medical sciences Models, Molecular Pharmacology. Drug treatments Phosphotyrosine - chemistry src Homology Domains Structure-Activity Relationship
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