X11L2, a New Member of the X11 Protein Family, Interacts with Alzheimer's β-Amyloid Precursor Protein

We screened proteins for interaction with Alzheimer's β-amyloid precursor protein (APP) and cloned a new member of the X11 protein family, X11L2. The PID/PTB element of X11L2 protein interacted with the intracellular domain of APP by GST binding assay, andin vivointeraction was confirmed by coi...

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Veröffentlicht in:	Biochemical and biophysical research communications 1999-02, Vol.255 (3), p.663-667
Hauptverfasser:	Tanahashi, Hiroshi, Tabira, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino Acid Sequence Amyloid beta-Protein Precursor - metabolism Carrier Proteins Cloning, Molecular Conserved Sequence - genetics Humans Membrane Proteins Molecular Sequence Data Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Protein Binding - genetics Proteins - chemistry Recombinant Fusion Proteins - genetics RNA, Messenger - metabolism Sequence Alignment Sequence Analysis, DNA src Homology Domains - genetics X11L2 protein
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