Comparative effects of vitamin K2 and vitamin E on experimental arteriosclerosis
The comparative effects of vitamin K2 and vitamin E on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis was induced by vitamin D2 with atherogenic diet. Both vitamin K2 (100 mg/kg b....
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| Veröffentlicht in: | International journal for vitamin and nutrition research 1999, Vol.69 (1), p.23-26 |
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| container_title | International journal for vitamin and nutrition research |
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| creator | Seyama, Y Hayashi, M Takegami, H Usami, E |
| description | The comparative effects of vitamin K2 and vitamin E on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis was induced by vitamin D2 with atherogenic diet. Both vitamin K2 (100 mg/kg b.w.) and vitamin E (40 mg/kg b.w.) inhibited the increase of Ca and P in the aorta and the elastin fr. from the arteriosclerotic rats. Vitamin K2 (50 mg/kg b.w.) also suppressed the deposition of Ca and P in the aorta, but there was no change due to vitamin K3 or geranylgeraniol (side chain of vitamin K2) administration. Both vitamin K2 and vitamin E showed lipid radical scavenging activity in the in vitro experiment. However, neither vitamin K3 nor geranylgeraniol exhibited anti-arteriosclerotic or radical scavenging activity under the above experimental conditions. It is suggested that vitamin K2 and vitamin E promoted an antiarteriosclerotic effect by radical scavenging activity. These actions of vitamin K2 are required in the structure of 2-methylnaphthoquinone and its side chain (geranylgeraniol). |
| doi_str_mv | 10.1024/0300-9831.69.1.23 |
| format | Article |
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Both vitamin K2 (100 mg/kg b.w.) and vitamin E (40 mg/kg b.w.) inhibited the increase of Ca and P in the aorta and the elastin fr. from the arteriosclerotic rats. Vitamin K2 (50 mg/kg b.w.) also suppressed the deposition of Ca and P in the aorta, but there was no change due to vitamin K3 or geranylgeraniol (side chain of vitamin K2) administration. Both vitamin K2 and vitamin E showed lipid radical scavenging activity in the in vitro experiment. However, neither vitamin K3 nor geranylgeraniol exhibited anti-arteriosclerotic or radical scavenging activity under the above experimental conditions. It is suggested that vitamin K2 and vitamin E promoted an antiarteriosclerotic effect by radical scavenging activity. These actions of vitamin K2 are required in the structure of 2-methylnaphthoquinone and its side chain (geranylgeraniol).</description><identifier>ISSN: 0300-9831</identifier><identifier>DOI: 10.1024/0300-9831.69.1.23</identifier><identifier>PMID: 10052017</identifier><identifier>CODEN: IJVNAP</identifier><language>eng</language><publisher>Bern: Hogrefe & Huber</publisher><subject>animal models ; Animals ; aorta ; Aorta - metabolism ; Arteriosclerosis - drug therapy ; Arteriosclerosis - etiology ; Arteriosclerosis - metabolism ; atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; calcium ; Calcium - metabolism ; Cardiology. Vascular system ; chemical structure ; Diet, Atherogenic ; elastin ; Elastin - metabolism ; ergocalciferol ; Ergocalciferols ; Free Radical Scavengers ; free radicals ; geraniol ; inhibitors ; lipid peroxidation ; Male ; Medical sciences ; mineral content ; molecular conformation ; Naphthoquinones - chemistry ; oxidation ; phosphorus ; Phosphorus - metabolism ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; vitamin E ; Vitamin E - pharmacology ; Vitamin E - therapeutic use ; vitamin K ; Vitamin K - chemistry ; Vitamin K - pharmacology ; Vitamin K - therapeutic use ; Vitamin K 3 ; vitamins</subject><ispartof>International journal for vitamin and nutrition research, 1999, Vol.69 (1), p.23-26</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1702374$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10052017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seyama, Y</creatorcontrib><creatorcontrib>Hayashi, M</creatorcontrib><creatorcontrib>Takegami, H</creatorcontrib><creatorcontrib>Usami, E</creatorcontrib><title>Comparative effects of vitamin K2 and vitamin E on experimental arteriosclerosis</title><title>International journal for vitamin and nutrition research</title><addtitle>Int J Vitam Nutr Res</addtitle><description>The comparative effects of vitamin K2 and vitamin E on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis was induced by vitamin D2 with atherogenic diet. Both vitamin K2 (100 mg/kg b.w.) and vitamin E (40 mg/kg b.w.) inhibited the increase of Ca and P in the aorta and the elastin fr. from the arteriosclerotic rats. Vitamin K2 (50 mg/kg b.w.) also suppressed the deposition of Ca and P in the aorta, but there was no change due to vitamin K3 or geranylgeraniol (side chain of vitamin K2) administration. Both vitamin K2 and vitamin E showed lipid radical scavenging activity in the in vitro experiment. However, neither vitamin K3 nor geranylgeraniol exhibited anti-arteriosclerotic or radical scavenging activity under the above experimental conditions. It is suggested that vitamin K2 and vitamin E promoted an antiarteriosclerotic effect by radical scavenging activity. These actions of vitamin K2 are required in the structure of 2-methylnaphthoquinone and its side chain (geranylgeraniol).</description><subject>animal models</subject><subject>Animals</subject><subject>aorta</subject><subject>Aorta - metabolism</subject><subject>Arteriosclerosis - drug therapy</subject><subject>Arteriosclerosis - etiology</subject><subject>Arteriosclerosis - metabolism</subject><subject>atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>calcium</subject><subject>Calcium - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>chemical structure</subject><subject>Diet, Atherogenic</subject><subject>elastin</subject><subject>Elastin - metabolism</subject><subject>ergocalciferol</subject><subject>Ergocalciferols</subject><subject>Free Radical Scavengers</subject><subject>free radicals</subject><subject>geraniol</subject><subject>inhibitors</subject><subject>lipid peroxidation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>mineral content</subject><subject>molecular conformation</subject><subject>Naphthoquinones - chemistry</subject><subject>oxidation</subject><subject>phosphorus</subject><subject>Phosphorus - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Structure-Activity Relationship</subject><subject>vitamin E</subject><subject>Vitamin E - pharmacology</subject><subject>Vitamin E - therapeutic use</subject><subject>vitamin K</subject><subject>Vitamin K - chemistry</subject><subject>Vitamin K - pharmacology</subject><subject>Vitamin K - therapeutic use</subject><subject>Vitamin K 3</subject><subject>vitamins</subject><issn>0300-9831</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1Lw0AQBuA9KLZWf4AXzUG8Jc7uZpPsUUr9wIKC9hwmu7MSSbI1mxb99wZa62l4h4eXYRi74JBwEOktSIBYF5InmU54IuQRmx52E3YawieAzHmRnrAJB1ACeD5lr3PfrrHHod5SRM6RGULkXbStB2zrLnoWEXb2EBeR7yL6XlNft9QN2ETYD2PwwTTU-1CHM3bssAl0vp8ztrpfvM8f4-XLw9P8bhk7kfIh5hVVqMBWkFkNqbPGWmWkcgQ6N5myUhgUAtFaQUpbmzlpJOQks6wgKuSM3ex6173_2lAYyrYOhpoGO_KbUGZaaZ2qfISXe7ipWrLlejwd-5_y7wcjuN4DDAYb12Nn6vDvchAyT0d2tWMOfYkf_UhWb2OBBKEVpFzLX0Vaczg</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Seyama, Y</creator><creator>Hayashi, M</creator><creator>Takegami, H</creator><creator>Usami, E</creator><general>Hogrefe & Huber</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Comparative effects of vitamin K2 and vitamin E on experimental arteriosclerosis</title><author>Seyama, Y ; Hayashi, M ; Takegami, H ; Usami, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f241t-1beba50db06d904fdcdd5c35fe097c65d32ca22aadd2e59dd6f3c307e3668ee83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>animal models</topic><topic>Animals</topic><topic>aorta</topic><topic>Aorta - metabolism</topic><topic>Arteriosclerosis - drug therapy</topic><topic>Arteriosclerosis - etiology</topic><topic>Arteriosclerosis - metabolism</topic><topic>atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>calcium</topic><topic>Calcium - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>chemical structure</topic><topic>Diet, Atherogenic</topic><topic>elastin</topic><topic>Elastin - metabolism</topic><topic>ergocalciferol</topic><topic>Ergocalciferols</topic><topic>Free Radical Scavengers</topic><topic>free radicals</topic><topic>geraniol</topic><topic>inhibitors</topic><topic>lipid peroxidation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>mineral content</topic><topic>molecular conformation</topic><topic>Naphthoquinones - chemistry</topic><topic>oxidation</topic><topic>phosphorus</topic><topic>Phosphorus - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Structure-Activity Relationship</topic><topic>vitamin E</topic><topic>Vitamin E - pharmacology</topic><topic>Vitamin E - therapeutic use</topic><topic>vitamin K</topic><topic>Vitamin K - chemistry</topic><topic>Vitamin K - pharmacology</topic><topic>Vitamin K - therapeutic use</topic><topic>Vitamin K 3</topic><topic>vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seyama, Y</creatorcontrib><creatorcontrib>Hayashi, M</creatorcontrib><creatorcontrib>Takegami, H</creatorcontrib><creatorcontrib>Usami, E</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>International journal for vitamin and nutrition research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seyama, Y</au><au>Hayashi, M</au><au>Takegami, H</au><au>Usami, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative effects of vitamin K2 and vitamin E on experimental arteriosclerosis</atitle><jtitle>International journal for vitamin and nutrition research</jtitle><addtitle>Int J Vitam Nutr Res</addtitle><date>1999</date><risdate>1999</risdate><volume>69</volume><issue>1</issue><spage>23</spage><epage>26</epage><pages>23-26</pages><issn>0300-9831</issn><coden>IJVNAP</coden><abstract>The comparative effects of vitamin K2 and vitamin E on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis was induced by vitamin D2 with atherogenic diet. Both vitamin K2 (100 mg/kg b.w.) and vitamin E (40 mg/kg b.w.) inhibited the increase of Ca and P in the aorta and the elastin fr. from the arteriosclerotic rats. Vitamin K2 (50 mg/kg b.w.) also suppressed the deposition of Ca and P in the aorta, but there was no change due to vitamin K3 or geranylgeraniol (side chain of vitamin K2) administration. Both vitamin K2 and vitamin E showed lipid radical scavenging activity in the in vitro experiment. However, neither vitamin K3 nor geranylgeraniol exhibited anti-arteriosclerotic or radical scavenging activity under the above experimental conditions. It is suggested that vitamin K2 and vitamin E promoted an antiarteriosclerotic effect by radical scavenging activity. These actions of vitamin K2 are required in the structure of 2-methylnaphthoquinone and its side chain (geranylgeraniol).</abstract><cop>Bern</cop><cop>Kirkland, WA</cop><cop>Toronto, ON</cop><pub>Hogrefe & Huber</pub><pmid>10052017</pmid><doi>10.1024/0300-9831.69.1.23</doi><tpages>4</tpages></addata></record> |
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| subjects | animal models Animals aorta Aorta - metabolism Arteriosclerosis - drug therapy Arteriosclerosis - etiology Arteriosclerosis - metabolism atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels calcium Calcium - metabolism Cardiology. Vascular system chemical structure Diet, Atherogenic elastin Elastin - metabolism ergocalciferol Ergocalciferols Free Radical Scavengers free radicals geraniol inhibitors lipid peroxidation Male Medical sciences mineral content molecular conformation Naphthoquinones - chemistry oxidation phosphorus Phosphorus - metabolism Rats Rats, Sprague-Dawley Structure-Activity Relationship vitamin E Vitamin E - pharmacology Vitamin E - therapeutic use vitamin K Vitamin K - chemistry Vitamin K - pharmacology Vitamin K - therapeutic use Vitamin K 3 vitamins |
| title | Comparative effects of vitamin K2 and vitamin E on experimental arteriosclerosis |
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