Spontaneous neoplastic lesions in Harlan Sprague-Dawley rats
In a 24-months study, the spontaneous tumour spectrum of the Hsd:Sprague-Dawley stock was examined. Pituitary gland tumours were found in 20 % of the males and 39 % of the females. This relatively low incidence, compared to other SPRD stocks, had little effect on the survival of females (50 %), due...
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| Veröffentlicht in: | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1999, Vol.51 (1), p.105-107 |
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| container_title | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie |
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| creator | Kaspareit, J. Rittinghausen, S. |
| description | In a 24-months study, the spontaneous tumour spectrum of the Hsd:Sprague-Dawley stock was examined. Pituitary gland tumours were found in 20 % of the males and 39 % of the females. This relatively low incidence, compared to other SPRD stocks, had little effect on the survival of females (50 %), due to the high incidence (76 %) of mammary gland tumours (predominantly fibroadenomas) that resulted in unscheduled sacrifices of many females. Other common neoplasms in Hsd: Sprague-Dawley rats were benign medullary tumours (27 % in males, 11 % in females), C-cell adenomas (23 % in males, 28 % in females), and endometrial stromal polyps (22 % in females). |
| doi_str_mv | 10.1016/S0940-2993(99)80079-7 |
| format | Article |
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Pituitary gland tumours were found in 20 % of the males and 39 % of the females. This relatively low incidence, compared to other SPRD stocks, had little effect on the survival of females (50 %), due to the high incidence (76 %) of mammary gland tumours (predominantly fibroadenomas) that resulted in unscheduled sacrifices of many females. Other common neoplasms in Hsd: Sprague-Dawley rats were benign medullary tumours (27 % in males, 11 % in females), C-cell adenomas (23 % in males, 28 % in females), and endometrial stromal polyps (22 % in females).</description><identifier>ISSN: 0940-2993</identifier><identifier>EISSN: 1618-1433</identifier><identifier>DOI: 10.1016/S0940-2993(99)80079-7</identifier><identifier>PMID: 10048722</identifier><language>eng</language><publisher>Jena: Elsevier GmbH</publisher><subject>Animal tumors. 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Pituitary gland tumours were found in 20 % of the males and 39 % of the females. This relatively low incidence, compared to other SPRD stocks, had little effect on the survival of females (50 %), due to the high incidence (76 %) of mammary gland tumours (predominantly fibroadenomas) that resulted in unscheduled sacrifices of many females. Other common neoplasms in Hsd: Sprague-Dawley rats were benign medullary tumours (27 % in males, 11 % in females), C-cell adenomas (23 % in males, 28 % in females), and endometrial stromal polyps (22 % in females).</description><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Female</subject><subject>Harlan Sprague-Dawley</subject><subject>Male</subject><subject>Mammary fibroadenomas</subject><subject>Medical sciences</subject><subject>Neoplasms - pathology</subject><subject>Pituitary gland adenomas</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Spontaneous animal tumors</subject><subject>Tumors</subject><subject>Tumour incidence</subject><subject>Tumour spectrum</subject><issn>0940-2993</issn><issn>1618-1433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BKUHET1U89E0GRBE1k9Y8LB6Dtl0KpFuW5Ousv_eul3UmwzMXJ6ZeXkIOWT0nFGWX0wpZDTlAOIU4ExTqiBVG2TEcqZTlgmxSUY_yA7ZjfGNUk5Bsm2ywyjNtOJ8RC6nbVN3tsZmEZO-t5WNnXdJhdE3dUx8nTzYUNk6mbbBvi4wvbGfFS6TYLu4T7ZKW0U8WM898nJ3-zx-SCdP94_j60nqBNAuhdJqUUqqJFeoSqXyjCtb5E4hh8IJym1Z5GymlZyVkmuWoxQatHUqA9Bc7JGT4W4bmvcFxs7MfXRYVUNuk4PsS4kelAPoQhNjwNK0wc9tWBpGzbc2s9Jmvp0YALPSZlS_d7R-sJjNsfizNXjqgeM1YKOzVRls7Xz85XKpeAY9djVg2Nv48BhMdB5rh4UP6DpTNP6fJF_Cmoh3</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Kaspareit, J.</creator><creator>Rittinghausen, S.</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Spontaneous neoplastic lesions in Harlan Sprague-Dawley rats</title><author>Kaspareit, J. ; Rittinghausen, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-9fa83f507527e7f776427ad6c7e29dc302afd61b875bf52816e53898ac7499823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Female</topic><topic>Harlan Sprague-Dawley</topic><topic>Male</topic><topic>Mammary fibroadenomas</topic><topic>Medical sciences</topic><topic>Neoplasms - pathology</topic><topic>Pituitary gland adenomas</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Spontaneous animal tumors</topic><topic>Tumors</topic><topic>Tumour incidence</topic><topic>Tumour spectrum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaspareit, J.</creatorcontrib><creatorcontrib>Rittinghausen, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaspareit, J.</au><au>Rittinghausen, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous neoplastic lesions in Harlan Sprague-Dawley rats</atitle><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle><addtitle>Exp Toxicol Pathol</addtitle><date>1999</date><risdate>1999</risdate><volume>51</volume><issue>1</issue><spage>105</spage><epage>107</epage><pages>105-107</pages><issn>0940-2993</issn><eissn>1618-1433</eissn><abstract>In a 24-months study, the spontaneous tumour spectrum of the Hsd:Sprague-Dawley stock was examined. Pituitary gland tumours were found in 20 % of the males and 39 % of the females. This relatively low incidence, compared to other SPRD stocks, had little effect on the survival of females (50 %), due to the high incidence (76 %) of mammary gland tumours (predominantly fibroadenomas) that resulted in unscheduled sacrifices of many females. Other common neoplasms in Hsd: Sprague-Dawley rats were benign medullary tumours (27 % in males, 11 % in females), C-cell adenomas (23 % in males, 28 % in females), and endometrial stromal polyps (22 % in females).</abstract><cop>Jena</cop><pub>Elsevier GmbH</pub><pmid>10048722</pmid><doi>10.1016/S0940-2993(99)80079-7</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0940-2993 |
| ispartof | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 1999, Vol.51 (1), p.105-107 |
| issn | 0940-2993 1618-1433 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animal tumors. Experimental tumors Animals Biological and medical sciences Body Weight Female Harlan Sprague-Dawley Male Mammary fibroadenomas Medical sciences Neoplasms - pathology Pituitary gland adenomas Rats Rats, Sprague-Dawley Spontaneous animal tumors Tumors Tumour incidence Tumour spectrum |
| title | Spontaneous neoplastic lesions in Harlan Sprague-Dawley rats |
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