Central nervous system T-cell lymphoproliferative disorder in a patient with chronic active Epstein-Barr virus infection
Central nervous system (CNS)-T cell lymphoproliferative disorder (T-LPD) developing during the course of chronic active Epstein-Barr virus (CAEBV) infection is reported. CAEBV was diagnosed in a 14-month-old boy with fever, cytopenia, hepatosplenomegaly, and abnormal high titers of anti-Epstein-Barr...
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| Veröffentlicht in: | Journal of pediatric hematology/oncology 1999, Vol.21 (1), p.42-46 |
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| container_title | Journal of pediatric hematology/oncology |
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| creator | OHGA, S TAKADA, H HONDA, K INAMURA, T GONDO, K OHSHIMA, K YAMAMOTO, M HARA, T |
| description | Central nervous system (CNS)-T cell lymphoproliferative disorder (T-LPD) developing during the course of chronic active Epstein-Barr virus (CAEBV) infection is reported.
CAEBV was diagnosed in a 14-month-old boy with fever, cytopenia, hepatosplenomegaly, and abnormal high titers of anti-Epstein-Barr virus (EBV) antibodies. At 8 years of age, he had a splenectomy because of progressive disease.
After 27 months of clinical remission, muscle weakness and paresthesia developed. Magnetic resonance imaging of his brain showed spotty T2 prolongation in left parietal, bilateral frontal, and temporal white matter with meningeal enhancement. Brain biopsy revealed the cerebral infiltration of CD3+, CD4+, CD8-, CD45RO+, CD56-, and EBV-encoded RNA 1+ cells.
The CNS involvement of EBV-associated T-LPD is a rare but serious complication in CAEBV without known underlying immunodeficiency. |
| doi_str_mv | 10.1097/00043426-199901000-00009 |
| format | Article |
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CAEBV was diagnosed in a 14-month-old boy with fever, cytopenia, hepatosplenomegaly, and abnormal high titers of anti-Epstein-Barr virus (EBV) antibodies. At 8 years of age, he had a splenectomy because of progressive disease.
After 27 months of clinical remission, muscle weakness and paresthesia developed. Magnetic resonance imaging of his brain showed spotty T2 prolongation in left parietal, bilateral frontal, and temporal white matter with meningeal enhancement. Brain biopsy revealed the cerebral infiltration of CD3+, CD4+, CD8-, CD45RO+, CD56-, and EBV-encoded RNA 1+ cells.
The CNS involvement of EBV-associated T-LPD is a rare but serious complication in CAEBV without known underlying immunodeficiency.</description><identifier>ISSN: 1077-4114</identifier><identifier>EISSN: 1536-3678</identifier><identifier>DOI: 10.1097/00043426-199901000-00009</identifier><identifier>PMID: 10029811</identifier><identifier>CODEN: JPHOFG</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Acute Disease ; AIDS/HIV ; Antibodies, Viral - blood ; Biological and medical sciences ; Brain Diseases - pathology ; Brain Diseases - virology ; Child ; Chronic Disease ; Disease Progression ; Hematologic and hematopoietic diseases ; Herpesviridae Infections - complications ; Herpesviridae Infections - pathology ; Herpesviridae Infections - virology ; Herpesvirus 4, Human ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoproliferative Disorders - pathology ; Lymphoproliferative Disorders - surgery ; Lymphoproliferative Disorders - virology ; Male ; Medical sciences ; Splenectomy ; T-Lymphocytes ; Tumor Virus Infections - complications ; Tumor Virus Infections - pathology ; Tumor Virus Infections - virology</subject><ispartof>Journal of pediatric hematology/oncology, 1999, Vol.21 (1), p.42-46</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-4fedbf33e7223cde25df6369741963e3c72b5325858da233787acf23f5abad0a3</citedby><cites>FETCH-LOGICAL-c340t-4fedbf33e7223cde25df6369741963e3c72b5325858da233787acf23f5abad0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,27928,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1665734$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10029811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OHGA, S</creatorcontrib><creatorcontrib>TAKADA, H</creatorcontrib><creatorcontrib>HONDA, K</creatorcontrib><creatorcontrib>INAMURA, T</creatorcontrib><creatorcontrib>GONDO, K</creatorcontrib><creatorcontrib>OHSHIMA, K</creatorcontrib><creatorcontrib>YAMAMOTO, M</creatorcontrib><creatorcontrib>HARA, T</creatorcontrib><title>Central nervous system T-cell lymphoproliferative disorder in a patient with chronic active Epstein-Barr virus infection</title><title>Journal of pediatric hematology/oncology</title><addtitle>J Pediatr Hematol Oncol</addtitle><description>Central nervous system (CNS)-T cell lymphoproliferative disorder (T-LPD) developing during the course of chronic active Epstein-Barr virus (CAEBV) infection is reported.
CAEBV was diagnosed in a 14-month-old boy with fever, cytopenia, hepatosplenomegaly, and abnormal high titers of anti-Epstein-Barr virus (EBV) antibodies. At 8 years of age, he had a splenectomy because of progressive disease.
After 27 months of clinical remission, muscle weakness and paresthesia developed. Magnetic resonance imaging of his brain showed spotty T2 prolongation in left parietal, bilateral frontal, and temporal white matter with meningeal enhancement. Brain biopsy revealed the cerebral infiltration of CD3+, CD4+, CD8-, CD45RO+, CD56-, and EBV-encoded RNA 1+ cells.
The CNS involvement of EBV-associated T-LPD is a rare but serious complication in CAEBV without known underlying immunodeficiency.</description><subject>Acute Disease</subject><subject>AIDS/HIV</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Brain Diseases - pathology</subject><subject>Brain Diseases - virology</subject><subject>Child</subject><subject>Chronic Disease</subject><subject>Disease Progression</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Herpesviridae Infections - complications</subject><subject>Herpesviridae Infections - pathology</subject><subject>Herpesviridae Infections - virology</subject><subject>Herpesvirus 4, Human</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoproliferative Disorders - pathology</subject><subject>Lymphoproliferative Disorders - surgery</subject><subject>Lymphoproliferative Disorders - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Splenectomy</subject><subject>T-Lymphocytes</subject><subject>Tumor Virus Infections - complications</subject><subject>Tumor Virus Infections - pathology</subject><subject>Tumor Virus Infections - virology</subject><issn>1077-4114</issn><issn>1536-3678</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkVuPFCEQhYnRuBf9C4YH4xsKVDc0jzpZdZNNfFmfOwxdZDDddAs9o_Pvt3ZnvIQQCvjOIXVgjCv5XklnP0gpG2i0Eco5JxVtBU3pnrFL1YIRYGz3nGpprWiUai7YVa0_pFSWVC_ZBSm065S6ZL83mNfiR56xHOZ95fVYV5z4vQg4jnw8TstuXso8pojFr-mAfEh1LgMWnjL3fKFDsuC_0rrjYVfmnAL34Ym8WcgrZfHJl8IPqZB9yhHpcs6v2Ivox4qvz-s1-_755n7zVdx9-3K7-XgnAjRyFU3EYRsB0GoNYUDdDtGAcbZRzgBCsHrbgm67thu8BrCd9SFqiK3f-kF6uGbvTr7UxM891rWfUn3szWekfnvjWhrQEdidwFDmWgvGfilp8uXYK9k_pt7_Sb3_m3r_lDpJ35zf2G8nHP4TnmIm4O0Z8DX4MRafQ6r_OGNa-hl4ALgRjGw</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>OHGA, S</creator><creator>TAKADA, H</creator><creator>HONDA, K</creator><creator>INAMURA, T</creator><creator>GONDO, K</creator><creator>OHSHIMA, K</creator><creator>YAMAMOTO, M</creator><creator>HARA, T</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Central nervous system T-cell lymphoproliferative disorder in a patient with chronic active Epstein-Barr virus infection</title><author>OHGA, S ; TAKADA, H ; HONDA, K ; INAMURA, T ; GONDO, K ; OHSHIMA, K ; YAMAMOTO, M ; HARA, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-4fedbf33e7223cde25df6369741963e3c72b5325858da233787acf23f5abad0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acute Disease</topic><topic>AIDS/HIV</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Brain Diseases - pathology</topic><topic>Brain Diseases - virology</topic><topic>Child</topic><topic>Chronic Disease</topic><topic>Disease Progression</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Herpesviridae Infections - complications</topic><topic>Herpesviridae Infections - pathology</topic><topic>Herpesviridae Infections - virology</topic><topic>Herpesvirus 4, Human</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoproliferative Disorders - pathology</topic><topic>Lymphoproliferative Disorders - surgery</topic><topic>Lymphoproliferative Disorders - virology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Splenectomy</topic><topic>T-Lymphocytes</topic><topic>Tumor Virus Infections - complications</topic><topic>Tumor Virus Infections - pathology</topic><topic>Tumor Virus Infections - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OHGA, S</creatorcontrib><creatorcontrib>TAKADA, H</creatorcontrib><creatorcontrib>HONDA, K</creatorcontrib><creatorcontrib>INAMURA, T</creatorcontrib><creatorcontrib>GONDO, K</creatorcontrib><creatorcontrib>OHSHIMA, K</creatorcontrib><creatorcontrib>YAMAMOTO, M</creatorcontrib><creatorcontrib>HARA, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric hematology/oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OHGA, S</au><au>TAKADA, H</au><au>HONDA, K</au><au>INAMURA, T</au><au>GONDO, K</au><au>OHSHIMA, K</au><au>YAMAMOTO, M</au><au>HARA, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central nervous system T-cell lymphoproliferative disorder in a patient with chronic active Epstein-Barr virus infection</atitle><jtitle>Journal of pediatric hematology/oncology</jtitle><addtitle>J Pediatr Hematol Oncol</addtitle><date>1999</date><risdate>1999</risdate><volume>21</volume><issue>1</issue><spage>42</spage><epage>46</epage><pages>42-46</pages><issn>1077-4114</issn><eissn>1536-3678</eissn><coden>JPHOFG</coden><abstract>Central nervous system (CNS)-T cell lymphoproliferative disorder (T-LPD) developing during the course of chronic active Epstein-Barr virus (CAEBV) infection is reported.
CAEBV was diagnosed in a 14-month-old boy with fever, cytopenia, hepatosplenomegaly, and abnormal high titers of anti-Epstein-Barr virus (EBV) antibodies. At 8 years of age, he had a splenectomy because of progressive disease.
After 27 months of clinical remission, muscle weakness and paresthesia developed. Magnetic resonance imaging of his brain showed spotty T2 prolongation in left parietal, bilateral frontal, and temporal white matter with meningeal enhancement. Brain biopsy revealed the cerebral infiltration of CD3+, CD4+, CD8-, CD45RO+, CD56-, and EBV-encoded RNA 1+ cells.
The CNS involvement of EBV-associated T-LPD is a rare but serious complication in CAEBV without known underlying immunodeficiency.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>10029811</pmid><doi>10.1097/00043426-199901000-00009</doi><tpages>5</tpages></addata></record> |
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| issn | 1077-4114 1536-3678 |
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| subjects | Acute Disease AIDS/HIV Antibodies, Viral - blood Biological and medical sciences Brain Diseases - pathology Brain Diseases - virology Child Chronic Disease Disease Progression Hematologic and hematopoietic diseases Herpesviridae Infections - complications Herpesviridae Infections - pathology Herpesviridae Infections - virology Herpesvirus 4, Human Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoproliferative Disorders - pathology Lymphoproliferative Disorders - surgery Lymphoproliferative Disorders - virology Male Medical sciences Splenectomy T-Lymphocytes Tumor Virus Infections - complications Tumor Virus Infections - pathology Tumor Virus Infections - virology |
| title | Central nervous system T-cell lymphoproliferative disorder in a patient with chronic active Epstein-Barr virus infection |
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