Toll-Like Receptor 3 Activation Induces Antiviral Immune Responses in Mouse Sertoli Cells

Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns and elicit antimicrobial immune responses. In the testis, viruses can induce pathological conditions, such as orchitis, and may participate in the etiology of testicular cancer; however, the molecular mechanisms involved rem...

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Veröffentlicht in:	Biology of reproduction 2008-10, Vol.79 (4), p.766-775
Hauptverfasser:	Starace, Donatella, Galli, Roberta, Paone, Alessio, Cesaris, Paola De, Filippini, Antonio, Ziparo, Elio, Riccioli, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Chemokine CCL2 - secretion Extracellular Signal-Regulated MAP Kinases - metabolism Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Immunity, Cellular - drug effects Immunity, Cellular - physiology Intercellular Adhesion Molecule-1 - metabolism Interferon Regulatory Factor-3 - metabolism Male Mammalian male genital system Mice NF-kappa B - metabolism Poly I-C - pharmacology Sertoli Cells - drug effects Sertoli Cells - immunology Signal Transduction - drug effects Toll-Like Receptor 3 - agonists Toll-Like Receptor 3 - metabolism Toll-Like Receptor 3 - physiology Vertebrates: reproduction Viruses - immunology
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