Renal Granulomatous sarcoidosis in childhood : a report of 11 cases and a review of the literature
We analysed retrospectively 11 children with renal granulomatous sarcoidosis confirmed by renal histology in order to describe the course and prognosis of the disease. Symptomatic sarcoidosis was diagnosed at a mean age of 10.1 years. Nine children had renal involvement at the time of diagnosis. In...
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| Veröffentlicht in: | European journal of pediatrics 1999-02, Vol.158 (2), p.154-159 |
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| creator | COUTANT, R LEROY, B NIAUDET, P LOIRAT, C DOMMERGUES, J. P ANDRE, J. L BACULARD, A BENSMAN, A |
| description | We analysed retrospectively 11 children with renal granulomatous sarcoidosis confirmed by renal histology in order to describe the course and prognosis of the disease. Symptomatic sarcoidosis was diagnosed at a mean age of 10.1 years. Nine children had renal involvement at the time of diagnosis. In the course of the disease, nine patients developed renal failure and mild proteinuria, seven had transient sterile leukocyturia, four showed microscopic haematuria, seven had a urinary concentrating defect, and enlarged kidneys were seen in three patients. One child had hypercalcaemia and hypercalciuria, none had hypertension. Light microscopy of the kidney showed interstitial infiltration by mononuclear cells in all children, interstitial fibrosis in nine patients, epithelioid granulomas in seven, tubular involvement in eight, and mild glomerular involvement in seven patients. Renal immunofluorescence was negative. Ten children received prednisone for 1-11 years. After a mean follow up of 5.5 years, three patients had entered end-stage renal failure and one had chronic insufficiency after interruption of medical supervision and prednisone therapy.
Renal failure, proteinuria, leukocyturia, haematuria, and concentration defect are the prominent features of renal granulomatous sarcoidosis in children. Steroid therapy, adjusted according to disease activity, may prevent end-stage renal failure. |
| doi_str_mv | 10.1007/s004310051038 |
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Renal failure, proteinuria, leukocyturia, haematuria, and concentration defect are the prominent features of renal granulomatous sarcoidosis in children. Steroid therapy, adjusted according to disease activity, may prevent end-stage renal failure.</description><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/s004310051038</identifier><identifier>PMID: 10048615</identifier><identifier>CODEN: EJPEDT</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adolescent ; Biological and medical sciences ; Biopsy ; Calcium Metabolism Disorders - complications ; Calcium Metabolism Disorders - diagnosis ; Child ; Child, Preschool ; Chronic Disease ; Female ; Follow-Up Studies ; Granuloma - complications ; Granuloma - diagnosis ; Humans ; Kidney - pathology ; Kidney Diseases - complications ; Kidney Diseases - diagnosis ; Kidney Failure, Chronic - diagnosis ; Kidney Failure, Chronic - etiology ; Literature reviews ; Male ; Medical sciences ; Retrospective Studies ; Sarcoidosis - complications ; Sarcoidosis - diagnosis ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><ispartof>European journal of pediatrics, 1999-02, Vol.158 (2), p.154-159</ispartof><rights>1999 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c277t-1849ac31f2a8b612101ba6b017d7da7a57e23c2568f3967ae785752d146ca1503</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1682163$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10048615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>COUTANT, R</creatorcontrib><creatorcontrib>LEROY, B</creatorcontrib><creatorcontrib>NIAUDET, P</creatorcontrib><creatorcontrib>LOIRAT, C</creatorcontrib><creatorcontrib>DOMMERGUES, J. P</creatorcontrib><creatorcontrib>ANDRE, J. L</creatorcontrib><creatorcontrib>BACULARD, A</creatorcontrib><creatorcontrib>BENSMAN, A</creatorcontrib><title>Renal Granulomatous sarcoidosis in childhood : a report of 11 cases and a review of the literature</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><description>We analysed retrospectively 11 children with renal granulomatous sarcoidosis confirmed by renal histology in order to describe the course and prognosis of the disease. Symptomatic sarcoidosis was diagnosed at a mean age of 10.1 years. Nine children had renal involvement at the time of diagnosis. In the course of the disease, nine patients developed renal failure and mild proteinuria, seven had transient sterile leukocyturia, four showed microscopic haematuria, seven had a urinary concentrating defect, and enlarged kidneys were seen in three patients. One child had hypercalcaemia and hypercalciuria, none had hypertension. Light microscopy of the kidney showed interstitial infiltration by mononuclear cells in all children, interstitial fibrosis in nine patients, epithelioid granulomas in seven, tubular involvement in eight, and mild glomerular involvement in seven patients. Renal immunofluorescence was negative. Ten children received prednisone for 1-11 years. After a mean follow up of 5.5 years, three patients had entered end-stage renal failure and one had chronic insufficiency after interruption of medical supervision and prednisone therapy.
Renal failure, proteinuria, leukocyturia, haematuria, and concentration defect are the prominent features of renal granulomatous sarcoidosis in children. Steroid therapy, adjusted according to disease activity, may prevent end-stage renal failure.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Calcium Metabolism Disorders - complications</subject><subject>Calcium Metabolism Disorders - diagnosis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Granuloma - complications</subject><subject>Granuloma - diagnosis</subject><subject>Humans</subject><subject>Kidney - pathology</subject><subject>Kidney Diseases - complications</subject><subject>Kidney Diseases - diagnosis</subject><subject>Kidney Failure, Chronic - diagnosis</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Literature reviews</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Retrospective Studies</subject><subject>Sarcoidosis - complications</subject><subject>Sarcoidosis - diagnosis</subject><subject>Sarcoidosis. 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L ; BACULARD, A ; BENSMAN, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c277t-1849ac31f2a8b612101ba6b017d7da7a57e23c2568f3967ae785752d146ca1503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Calcium Metabolism Disorders - complications</topic><topic>Calcium Metabolism Disorders - diagnosis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Granuloma - complications</topic><topic>Granuloma - diagnosis</topic><topic>Humans</topic><topic>Kidney - pathology</topic><topic>Kidney Diseases - complications</topic><topic>Kidney Diseases - diagnosis</topic><topic>Kidney Failure, Chronic - diagnosis</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Literature reviews</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Retrospective Studies</topic><topic>Sarcoidosis - complications</topic><topic>Sarcoidosis - diagnosis</topic><topic>Sarcoidosis. 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P</au><au>ANDRE, J. L</au><au>BACULARD, A</au><au>BENSMAN, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal Granulomatous sarcoidosis in childhood : a report of 11 cases and a review of the literature</atitle><jtitle>European journal of pediatrics</jtitle><addtitle>Eur J Pediatr</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>158</volume><issue>2</issue><spage>154</spage><epage>159</epage><pages>154-159</pages><issn>0340-6199</issn><eissn>1432-1076</eissn><coden>EJPEDT</coden><abstract>We analysed retrospectively 11 children with renal granulomatous sarcoidosis confirmed by renal histology in order to describe the course and prognosis of the disease. Symptomatic sarcoidosis was diagnosed at a mean age of 10.1 years. Nine children had renal involvement at the time of diagnosis. In the course of the disease, nine patients developed renal failure and mild proteinuria, seven had transient sterile leukocyturia, four showed microscopic haematuria, seven had a urinary concentrating defect, and enlarged kidneys were seen in three patients. One child had hypercalcaemia and hypercalciuria, none had hypertension. Light microscopy of the kidney showed interstitial infiltration by mononuclear cells in all children, interstitial fibrosis in nine patients, epithelioid granulomas in seven, tubular involvement in eight, and mild glomerular involvement in seven patients. Renal immunofluorescence was negative. Ten children received prednisone for 1-11 years. After a mean follow up of 5.5 years, three patients had entered end-stage renal failure and one had chronic insufficiency after interruption of medical supervision and prednisone therapy.
Renal failure, proteinuria, leukocyturia, haematuria, and concentration defect are the prominent features of renal granulomatous sarcoidosis in children. Steroid therapy, adjusted according to disease activity, may prevent end-stage renal failure.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>10048615</pmid><doi>10.1007/s004310051038</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences Biopsy Calcium Metabolism Disorders - complications Calcium Metabolism Disorders - diagnosis Child Child, Preschool Chronic Disease Female Follow-Up Studies Granuloma - complications Granuloma - diagnosis Humans Kidney - pathology Kidney Diseases - complications Kidney Diseases - diagnosis Kidney Failure, Chronic - diagnosis Kidney Failure, Chronic - etiology Literature reviews Male Medical sciences Retrospective Studies Sarcoidosis - complications Sarcoidosis - diagnosis Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis |
| title | Renal Granulomatous sarcoidosis in childhood : a report of 11 cases and a review of the literature |
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