Foetal cross-protection experiments between type 1 and type 2 bovine viral diarrhoea virus in pregnant ewes
A flock of 82 non-pregnant ewes was split into three immunisation groups and given an intranasal dose of either cell culture medium, or a type 1 or a type 2 bovine viral diarrhoea virus (BVDV-1 or BVDV-2). Two months later the flock was reconstituted and after a further three weeks, the ewes were br...
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Veröffentlicht in: | Veterinary microbiology 1999, Vol.64 (2), p.185-196 |
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description | A flock of 82 non-pregnant ewes was split into three immunisation groups and given an intranasal dose of either cell culture medium, or a type 1 or a type 2 bovine viral diarrhoea virus (BVDV-1 or BVDV-2). Two months later the flock was reconstituted and after a further three weeks, the ewes were bred to pestivirus negative rams after synchronisation of oestrus using progesterone sponges. Fifty-five ewes were segregated into three challenge groups, each of which comprised ewes from different immunisation groups. At 7 weeks gestation, one challenge group was given an intranasal dose of cell culture medium, whilst the other two were given intranasal doses of either BVDV-1 or BVDV-2, using the same inocula as for the immunisations. Three weeks later, the ewes were killed and their foetuses tested for the presence of BVDV-1 and BVDV-2. The results showed that immunisation of six ewes without subsequent challenge did not lead to infection of any of their 11 foetuses. Challenge with BVDV-1 or BVDV-2 in the absence of immunisation lead to 15 out of 15 or 11 out of 14 foetuses becoming infected, respectively. Immunisation with the homologous virus to that used for challenge resulted in complete protection of 32 foetuses from 15 ewes. Heterologous protection was one way. All 12 foetuses from ewes immunised with BVDV-1 were protected from challenge with BVDV-2, whereas 18 foetuses from ewes immunised with BVDV-2 were all infected after challenge with BVDV-1. This provides evidence that a recent exposure to infection with one pestivirus does not necessarily induce foetal protection against another. The one-way result suggests that factors other than antigenic differences are involved in cross-protection. |
doi_str_mv | 10.1016/S0378-1135(98)00269-7 |
format | Article |
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Two months later the flock was reconstituted and after a further three weeks, the ewes were bred to pestivirus negative rams after synchronisation of oestrus using progesterone sponges. Fifty-five ewes were segregated into three challenge groups, each of which comprised ewes from different immunisation groups. At 7 weeks gestation, one challenge group was given an intranasal dose of cell culture medium, whilst the other two were given intranasal doses of either BVDV-1 or BVDV-2, using the same inocula as for the immunisations. Three weeks later, the ewes were killed and their foetuses tested for the presence of BVDV-1 and BVDV-2. The results showed that immunisation of six ewes without subsequent challenge did not lead to infection of any of their 11 foetuses. Challenge with BVDV-1 or BVDV-2 in the absence of immunisation lead to 15 out of 15 or 11 out of 14 foetuses becoming infected, respectively. Immunisation with the homologous virus to that used for challenge resulted in complete protection of 32 foetuses from 15 ewes. Heterologous protection was one way. All 12 foetuses from ewes immunised with BVDV-1 were protected from challenge with BVDV-2, whereas 18 foetuses from ewes immunised with BVDV-2 were all infected after challenge with BVDV-1. This provides evidence that a recent exposure to infection with one pestivirus does not necessarily induce foetal protection against another. The one-way result suggests that factors other than antigenic differences are involved in cross-protection.</description><identifier>ISSN: 0378-1135</identifier><identifier>EISSN: 1873-2542</identifier><identifier>DOI: 10.1016/S0378-1135(98)00269-7</identifier><identifier>PMID: 10028172</identifier><identifier>CODEN: VMICDQ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Administration, Intranasal ; Animals ; Antibodies, Monoclonal ; Antibodies, Viral - analysis ; Biological and medical sciences ; Bovine diarrhea virus ; BOVINE DIARRHOEA PESTIVIRUS ; Bovine Virus Diarrhea-Mucosal Disease - prevention & control ; Bovine Virus Diarrhea-Mucosal Disease - virology ; BREBIS ; BVD ; Cattle ; Cross-protection ; Diarrhea Virus 1, Bovine Viral - classification ; Diarrhea Virus 1, Bovine Viral - immunology ; Diarrhea Virus 2, Bovine Viral - classification ; Diarrhea Virus 2, Bovine Viral - immunology ; Disease Models, Animal ; Disease Reservoirs ; EWES ; EXPERIMENTAL INFECTION ; Female ; Fetal Blood - virology ; FETO ; Fetus - immunology ; Foetal infection ; FOETUS ; Fundamental and applied biological sciences. Psychology ; GESTACION ; GESTATION ; IMMUNE RESPONSE ; IMMUNISATION ; IMMUNITE ; IMMUNITE MATERNELLE ; IMMUNITY ; IMMUNIZATION ; INFECCION EXPERIMENTAL ; INFECTION EXPERIMENTALE ; INMUNIDAD ; INMUNIDAD MATERNAL ; INMUNIZACION ; Kidney - virology ; Male ; MATERNAL IMMUNITY ; Microbiology ; Neutralization Tests - veterinary ; OVEJA ; Pestivirus ; PESTIVIRUS DE LA DIARREA BOVINA ; PESTIVIRUS MALADIE DES MUQUEUSES ; PREGNANCY ; Random Allocation ; REPONSE IMMUNITAIRE ; RESPUESTA INMUNOLOGICA ; Sheep ; Sheep model ; Spleen - virology ; Vaccination - veterinary ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Virology</subject><ispartof>Veterinary microbiology, 1999, Vol.64 (2), p.185-196</ispartof><rights>1999 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-f4e7b21cd4d465b0ac174268bfbb0bd2532a8e23ccfe5b418886d1147f7bd2483</citedby><cites>FETCH-LOGICAL-c443t-f4e7b21cd4d465b0ac174268bfbb0bd2532a8e23ccfe5b418886d1147f7bd2483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-1135(98)00269-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3548,4021,4047,4048,23928,23929,25138,27921,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1718823$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10028172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Midtlyng, PJ</contributor><contributor>Nyberg, O</contributor><contributor>Boersum, JB (eds)</contributor><creatorcontrib>Paton, D.J</creatorcontrib><creatorcontrib>Sharp, G</creatorcontrib><creatorcontrib>Ibata, G</creatorcontrib><title>Foetal cross-protection experiments between type 1 and type 2 bovine viral diarrhoea virus in pregnant ewes</title><title>Veterinary microbiology</title><addtitle>Vet Microbiol</addtitle><description>A flock of 82 non-pregnant ewes was split into three immunisation groups and given an intranasal dose of either cell culture medium, or a type 1 or a type 2 bovine viral diarrhoea virus (BVDV-1 or BVDV-2). Two months later the flock was reconstituted and after a further three weeks, the ewes were bred to pestivirus negative rams after synchronisation of oestrus using progesterone sponges. Fifty-five ewes were segregated into three challenge groups, each of which comprised ewes from different immunisation groups. At 7 weeks gestation, one challenge group was given an intranasal dose of cell culture medium, whilst the other two were given intranasal doses of either BVDV-1 or BVDV-2, using the same inocula as for the immunisations. Three weeks later, the ewes were killed and their foetuses tested for the presence of BVDV-1 and BVDV-2. The results showed that immunisation of six ewes without subsequent challenge did not lead to infection of any of their 11 foetuses. Challenge with BVDV-1 or BVDV-2 in the absence of immunisation lead to 15 out of 15 or 11 out of 14 foetuses becoming infected, respectively. Immunisation with the homologous virus to that used for challenge resulted in complete protection of 32 foetuses from 15 ewes. Heterologous protection was one way. All 12 foetuses from ewes immunised with BVDV-1 were protected from challenge with BVDV-2, whereas 18 foetuses from ewes immunised with BVDV-2 were all infected after challenge with BVDV-1. This provides evidence that a recent exposure to infection with one pestivirus does not necessarily induce foetal protection against another. The one-way result suggests that factors other than antigenic differences are involved in cross-protection.</description><subject>Administration, Intranasal</subject><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Antibodies, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>Bovine diarrhea virus</subject><subject>BOVINE DIARRHOEA PESTIVIRUS</subject><subject>Bovine Virus Diarrhea-Mucosal Disease - prevention & control</subject><subject>Bovine Virus Diarrhea-Mucosal Disease - virology</subject><subject>BREBIS</subject><subject>BVD</subject><subject>Cattle</subject><subject>Cross-protection</subject><subject>Diarrhea Virus 1, Bovine Viral - classification</subject><subject>Diarrhea Virus 1, Bovine Viral - immunology</subject><subject>Diarrhea Virus 2, Bovine Viral - classification</subject><subject>Diarrhea Virus 2, Bovine Viral - immunology</subject><subject>Disease Models, Animal</subject><subject>Disease Reservoirs</subject><subject>EWES</subject><subject>EXPERIMENTAL INFECTION</subject><subject>Female</subject><subject>Fetal Blood - virology</subject><subject>FETO</subject><subject>Fetus - immunology</subject><subject>Foetal infection</subject><subject>FOETUS</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GESTACION</subject><subject>GESTATION</subject><subject>IMMUNE RESPONSE</subject><subject>IMMUNISATION</subject><subject>IMMUNITE</subject><subject>IMMUNITE MATERNELLE</subject><subject>IMMUNITY</subject><subject>IMMUNIZATION</subject><subject>INFECCION EXPERIMENTAL</subject><subject>INFECTION EXPERIMENTALE</subject><subject>INMUNIDAD</subject><subject>INMUNIDAD MATERNAL</subject><subject>INMUNIZACION</subject><subject>Kidney - virology</subject><subject>Male</subject><subject>MATERNAL IMMUNITY</subject><subject>Microbiology</subject><subject>Neutralization Tests - veterinary</subject><subject>OVEJA</subject><subject>Pestivirus</subject><subject>PESTIVIRUS DE LA DIARREA BOVINA</subject><subject>PESTIVIRUS MALADIE DES MUQUEUSES</subject><subject>PREGNANCY</subject><subject>Random Allocation</subject><subject>REPONSE IMMUNITAIRE</subject><subject>RESPUESTA INMUNOLOGICA</subject><subject>Sheep</subject><subject>Sheep model</subject><subject>Spleen - virology</subject><subject>Vaccination - veterinary</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Virology</subject><issn>0378-1135</issn><issn>1873-2542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS1ERZfCRyjyASE4BPwvtnNCqKKAtIIDcLZsZ1IMWSfY3m377fFuVqW3nmxrfvPG8x5C55S8pYTKd98JV7qhlLevO_2GECa7Rj1CK6oVb1gr2GO0ukNO0dOcfxNCRCfJE3RKK6-pYiv053KCYkfs05RzM6epgC9hihhuZkhhA7Fk7KBcA0RcbmfAFNvYL1eG3bQLEfAupKrRB5vSrwns_r3NOEQ8J7iKNhYM15CfoZPBjhmeH88z9PPy44-Lz83626cvFx_WjReCl2YQoByjvhe9kK0j1lMlmNRucI64nrWcWQ2Mez9A6wTVWsueUqEGVatC8zP0atGt6_zdQi5mE7KHcbQRpm02smu7llP5IFgdklxqUcF2AQ82JRjMXL2x6dZQYvZxmEMcZu-16bQ5xGFU7XtxHLB1G-jvdS3-V-DlEbDZ23FINvqQ_3Oqbsd4xc4XbLCTsVepIl_XtOu6qkPb_Zz3Sx2qrbsAyWQfIHroQ6p5mn4KD_z0H6VZsF8</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Paton, D.J</creator><creator>Sharp, G</creator><creator>Ibata, G</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Foetal cross-protection experiments between type 1 and type 2 bovine viral diarrhoea virus in pregnant ewes</title><author>Paton, D.J ; Sharp, G ; Ibata, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-f4e7b21cd4d465b0ac174268bfbb0bd2532a8e23ccfe5b418886d1147f7bd2483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Administration, Intranasal</topic><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Antibodies, Viral - analysis</topic><topic>Biological and medical sciences</topic><topic>Bovine diarrhea virus</topic><topic>BOVINE DIARRHOEA PESTIVIRUS</topic><topic>Bovine Virus Diarrhea-Mucosal Disease - prevention & control</topic><topic>Bovine Virus Diarrhea-Mucosal Disease - virology</topic><topic>BREBIS</topic><topic>BVD</topic><topic>Cattle</topic><topic>Cross-protection</topic><topic>Diarrhea Virus 1, Bovine Viral - classification</topic><topic>Diarrhea Virus 1, Bovine Viral - immunology</topic><topic>Diarrhea Virus 2, Bovine Viral - classification</topic><topic>Diarrhea Virus 2, Bovine Viral - immunology</topic><topic>Disease Models, Animal</topic><topic>Disease Reservoirs</topic><topic>EWES</topic><topic>EXPERIMENTAL INFECTION</topic><topic>Female</topic><topic>Fetal Blood - virology</topic><topic>FETO</topic><topic>Fetus - immunology</topic><topic>Foetal infection</topic><topic>FOETUS</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GESTACION</topic><topic>GESTATION</topic><topic>IMMUNE RESPONSE</topic><topic>IMMUNISATION</topic><topic>IMMUNITE</topic><topic>IMMUNITE MATERNELLE</topic><topic>IMMUNITY</topic><topic>IMMUNIZATION</topic><topic>INFECCION EXPERIMENTAL</topic><topic>INFECTION EXPERIMENTALE</topic><topic>INMUNIDAD</topic><topic>INMUNIDAD MATERNAL</topic><topic>INMUNIZACION</topic><topic>Kidney - virology</topic><topic>Male</topic><topic>MATERNAL IMMUNITY</topic><topic>Microbiology</topic><topic>Neutralization Tests - veterinary</topic><topic>OVEJA</topic><topic>Pestivirus</topic><topic>PESTIVIRUS DE LA DIARREA BOVINA</topic><topic>PESTIVIRUS MALADIE DES MUQUEUSES</topic><topic>PREGNANCY</topic><topic>Random Allocation</topic><topic>REPONSE IMMUNITAIRE</topic><topic>RESPUESTA INMUNOLOGICA</topic><topic>Sheep</topic><topic>Sheep model</topic><topic>Spleen - virology</topic><topic>Vaccination - veterinary</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paton, D.J</creatorcontrib><creatorcontrib>Sharp, G</creatorcontrib><creatorcontrib>Ibata, G</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paton, D.J</au><au>Sharp, G</au><au>Ibata, G</au><au>Midtlyng, PJ</au><au>Nyberg, O</au><au>Boersum, JB (eds)</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Foetal cross-protection experiments between type 1 and type 2 bovine viral diarrhoea virus in pregnant ewes</atitle><jtitle>Veterinary microbiology</jtitle><addtitle>Vet Microbiol</addtitle><date>1999</date><risdate>1999</risdate><volume>64</volume><issue>2</issue><spage>185</spage><epage>196</epage><pages>185-196</pages><issn>0378-1135</issn><eissn>1873-2542</eissn><coden>VMICDQ</coden><abstract>A flock of 82 non-pregnant ewes was split into three immunisation groups and given an intranasal dose of either cell culture medium, or a type 1 or a type 2 bovine viral diarrhoea virus (BVDV-1 or BVDV-2). Two months later the flock was reconstituted and after a further three weeks, the ewes were bred to pestivirus negative rams after synchronisation of oestrus using progesterone sponges. Fifty-five ewes were segregated into three challenge groups, each of which comprised ewes from different immunisation groups. At 7 weeks gestation, one challenge group was given an intranasal dose of cell culture medium, whilst the other two were given intranasal doses of either BVDV-1 or BVDV-2, using the same inocula as for the immunisations. Three weeks later, the ewes were killed and their foetuses tested for the presence of BVDV-1 and BVDV-2. The results showed that immunisation of six ewes without subsequent challenge did not lead to infection of any of their 11 foetuses. Challenge with BVDV-1 or BVDV-2 in the absence of immunisation lead to 15 out of 15 or 11 out of 14 foetuses becoming infected, respectively. Immunisation with the homologous virus to that used for challenge resulted in complete protection of 32 foetuses from 15 ewes. Heterologous protection was one way. All 12 foetuses from ewes immunised with BVDV-1 were protected from challenge with BVDV-2, whereas 18 foetuses from ewes immunised with BVDV-2 were all infected after challenge with BVDV-1. This provides evidence that a recent exposure to infection with one pestivirus does not necessarily induce foetal protection against another. The one-way result suggests that factors other than antigenic differences are involved in cross-protection.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>10028172</pmid><doi>10.1016/S0378-1135(98)00269-7</doi><tpages>12</tpages></addata></record> |
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subjects | Administration, Intranasal Animals Antibodies, Monoclonal Antibodies, Viral - analysis Biological and medical sciences Bovine diarrhea virus BOVINE DIARRHOEA PESTIVIRUS Bovine Virus Diarrhea-Mucosal Disease - prevention & control Bovine Virus Diarrhea-Mucosal Disease - virology BREBIS BVD Cattle Cross-protection Diarrhea Virus 1, Bovine Viral - classification Diarrhea Virus 1, Bovine Viral - immunology Diarrhea Virus 2, Bovine Viral - classification Diarrhea Virus 2, Bovine Viral - immunology Disease Models, Animal Disease Reservoirs EWES EXPERIMENTAL INFECTION Female Fetal Blood - virology FETO Fetus - immunology Foetal infection FOETUS Fundamental and applied biological sciences. Psychology GESTACION GESTATION IMMUNE RESPONSE IMMUNISATION IMMUNITE IMMUNITE MATERNELLE IMMUNITY IMMUNIZATION INFECCION EXPERIMENTAL INFECTION EXPERIMENTALE INMUNIDAD INMUNIDAD MATERNAL INMUNIZACION Kidney - virology Male MATERNAL IMMUNITY Microbiology Neutralization Tests - veterinary OVEJA Pestivirus PESTIVIRUS DE LA DIARREA BOVINA PESTIVIRUS MALADIE DES MUQUEUSES PREGNANCY Random Allocation REPONSE IMMUNITAIRE RESPUESTA INMUNOLOGICA Sheep Sheep model Spleen - virology Vaccination - veterinary Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Virology |
title | Foetal cross-protection experiments between type 1 and type 2 bovine viral diarrhoea virus in pregnant ewes |
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