Foetal cross-protection experiments between type 1 and type 2 bovine viral diarrhoea virus in pregnant ewes

A flock of 82 non-pregnant ewes was split into three immunisation groups and given an intranasal dose of either cell culture medium, or a type 1 or a type 2 bovine viral diarrhoea virus (BVDV-1 or BVDV-2). Two months later the flock was reconstituted and after a further three weeks, the ewes were br...

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Veröffentlicht in:Veterinary microbiology 1999, Vol.64 (2), p.185-196
Hauptverfasser: Paton, D.J, Sharp, G, Ibata, G
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Sharp, G
Ibata, G
description A flock of 82 non-pregnant ewes was split into three immunisation groups and given an intranasal dose of either cell culture medium, or a type 1 or a type 2 bovine viral diarrhoea virus (BVDV-1 or BVDV-2). Two months later the flock was reconstituted and after a further three weeks, the ewes were bred to pestivirus negative rams after synchronisation of oestrus using progesterone sponges. Fifty-five ewes were segregated into three challenge groups, each of which comprised ewes from different immunisation groups. At 7 weeks gestation, one challenge group was given an intranasal dose of cell culture medium, whilst the other two were given intranasal doses of either BVDV-1 or BVDV-2, using the same inocula as for the immunisations. Three weeks later, the ewes were killed and their foetuses tested for the presence of BVDV-1 and BVDV-2. The results showed that immunisation of six ewes without subsequent challenge did not lead to infection of any of their 11 foetuses. Challenge with BVDV-1 or BVDV-2 in the absence of immunisation lead to 15 out of 15 or 11 out of 14 foetuses becoming infected, respectively. Immunisation with the homologous virus to that used for challenge resulted in complete protection of 32 foetuses from 15 ewes. Heterologous protection was one way. All 12 foetuses from ewes immunised with BVDV-1 were protected from challenge with BVDV-2, whereas 18 foetuses from ewes immunised with BVDV-2 were all infected after challenge with BVDV-1. This provides evidence that a recent exposure to infection with one pestivirus does not necessarily induce foetal protection against another. The one-way result suggests that factors other than antigenic differences are involved in cross-protection.
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Two months later the flock was reconstituted and after a further three weeks, the ewes were bred to pestivirus negative rams after synchronisation of oestrus using progesterone sponges. Fifty-five ewes were segregated into three challenge groups, each of which comprised ewes from different immunisation groups. At 7 weeks gestation, one challenge group was given an intranasal dose of cell culture medium, whilst the other two were given intranasal doses of either BVDV-1 or BVDV-2, using the same inocula as for the immunisations. Three weeks later, the ewes were killed and their foetuses tested for the presence of BVDV-1 and BVDV-2. The results showed that immunisation of six ewes without subsequent challenge did not lead to infection of any of their 11 foetuses. Challenge with BVDV-1 or BVDV-2 in the absence of immunisation lead to 15 out of 15 or 11 out of 14 foetuses becoming infected, respectively. 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Psychology</topic><topic>GESTACION</topic><topic>GESTATION</topic><topic>IMMUNE RESPONSE</topic><topic>IMMUNISATION</topic><topic>IMMUNITE</topic><topic>IMMUNITE MATERNELLE</topic><topic>IMMUNITY</topic><topic>IMMUNIZATION</topic><topic>INFECCION EXPERIMENTAL</topic><topic>INFECTION EXPERIMENTALE</topic><topic>INMUNIDAD</topic><topic>INMUNIDAD MATERNAL</topic><topic>INMUNIZACION</topic><topic>Kidney - virology</topic><topic>Male</topic><topic>MATERNAL IMMUNITY</topic><topic>Microbiology</topic><topic>Neutralization Tests - veterinary</topic><topic>OVEJA</topic><topic>Pestivirus</topic><topic>PESTIVIRUS DE LA DIARREA BOVINA</topic><topic>PESTIVIRUS MALADIE DES MUQUEUSES</topic><topic>PREGNANCY</topic><topic>Random Allocation</topic><topic>REPONSE IMMUNITAIRE</topic><topic>RESPUESTA INMUNOLOGICA</topic><topic>Sheep</topic><topic>Sheep model</topic><topic>Spleen - virology</topic><topic>Vaccination - veterinary</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paton, D.J</creatorcontrib><creatorcontrib>Sharp, G</creatorcontrib><creatorcontrib>Ibata, G</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paton, D.J</au><au>Sharp, G</au><au>Ibata, G</au><au>Midtlyng, PJ</au><au>Nyberg, O</au><au>Boersum, JB (eds)</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Foetal cross-protection experiments between type 1 and type 2 bovine viral diarrhoea virus in pregnant ewes</atitle><jtitle>Veterinary microbiology</jtitle><addtitle>Vet Microbiol</addtitle><date>1999</date><risdate>1999</risdate><volume>64</volume><issue>2</issue><spage>185</spage><epage>196</epage><pages>185-196</pages><issn>0378-1135</issn><eissn>1873-2542</eissn><coden>VMICDQ</coden><abstract>A flock of 82 non-pregnant ewes was split into three immunisation groups and given an intranasal dose of either cell culture medium, or a type 1 or a type 2 bovine viral diarrhoea virus (BVDV-1 or BVDV-2). Two months later the flock was reconstituted and after a further three weeks, the ewes were bred to pestivirus negative rams after synchronisation of oestrus using progesterone sponges. Fifty-five ewes were segregated into three challenge groups, each of which comprised ewes from different immunisation groups. At 7 weeks gestation, one challenge group was given an intranasal dose of cell culture medium, whilst the other two were given intranasal doses of either BVDV-1 or BVDV-2, using the same inocula as for the immunisations. Three weeks later, the ewes were killed and their foetuses tested for the presence of BVDV-1 and BVDV-2. The results showed that immunisation of six ewes without subsequent challenge did not lead to infection of any of their 11 foetuses. Challenge with BVDV-1 or BVDV-2 in the absence of immunisation lead to 15 out of 15 or 11 out of 14 foetuses becoming infected, respectively. Immunisation with the homologous virus to that used for challenge resulted in complete protection of 32 foetuses from 15 ewes. Heterologous protection was one way. All 12 foetuses from ewes immunised with BVDV-1 were protected from challenge with BVDV-2, whereas 18 foetuses from ewes immunised with BVDV-2 were all infected after challenge with BVDV-1. This provides evidence that a recent exposure to infection with one pestivirus does not necessarily induce foetal protection against another. The one-way result suggests that factors other than antigenic differences are involved in cross-protection.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>10028172</pmid><doi>10.1016/S0378-1135(98)00269-7</doi><tpages>12</tpages></addata></record>
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identifier ISSN: 0378-1135
ispartof Veterinary microbiology, 1999, Vol.64 (2), p.185-196
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subjects Administration, Intranasal
Animals
Antibodies, Monoclonal
Antibodies, Viral - analysis
Biological and medical sciences
Bovine diarrhea virus
BOVINE DIARRHOEA PESTIVIRUS
Bovine Virus Diarrhea-Mucosal Disease - prevention & control
Bovine Virus Diarrhea-Mucosal Disease - virology
BREBIS
BVD
Cattle
Cross-protection
Diarrhea Virus 1, Bovine Viral - classification
Diarrhea Virus 1, Bovine Viral - immunology
Diarrhea Virus 2, Bovine Viral - classification
Diarrhea Virus 2, Bovine Viral - immunology
Disease Models, Animal
Disease Reservoirs
EWES
EXPERIMENTAL INFECTION
Female
Fetal Blood - virology
FETO
Fetus - immunology
Foetal infection
FOETUS
Fundamental and applied biological sciences. Psychology
GESTACION
GESTATION
IMMUNE RESPONSE
IMMUNISATION
IMMUNITE
IMMUNITE MATERNELLE
IMMUNITY
IMMUNIZATION
INFECCION EXPERIMENTAL
INFECTION EXPERIMENTALE
INMUNIDAD
INMUNIDAD MATERNAL
INMUNIZACION
Kidney - virology
Male
MATERNAL IMMUNITY
Microbiology
Neutralization Tests - veterinary
OVEJA
Pestivirus
PESTIVIRUS DE LA DIARREA BOVINA
PESTIVIRUS MALADIE DES MUQUEUSES
PREGNANCY
Random Allocation
REPONSE IMMUNITAIRE
RESPUESTA INMUNOLOGICA
Sheep
Sheep model
Spleen - virology
Vaccination - veterinary
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Virology
title Foetal cross-protection experiments between type 1 and type 2 bovine viral diarrhoea virus in pregnant ewes
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