Human DNA repair systems: An overview
DNA repair systems act to maintain genome integrity in the face of replication errors, environmental insults, and the cumulative effects of age. More than 70 human genes directly involved in the five major pathways of DNA repair have been described, including chromosomal location and cDNA sequence....
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| Veröffentlicht in: | Environmental and molecular mutagenesis 1999, Vol.33 (1), p.3-20 |
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| container_title | Environmental and molecular mutagenesis |
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| creator | Yu, Zhe Chen, Jian Ford, Barry N. Brackley, Moyra E. Glickman, Barry W. |
| description | DNA repair systems act to maintain genome integrity in the face of replication errors, environmental insults, and the cumulative effects of age. More than 70 human genes directly involved in the five major pathways of DNA repair have been described, including chromosomal location and cDNA sequence. However, a great deal of information as to the precise functions of these genes and their role in human health is still lacking. Hence, we summarize what is known about these genes and their contra part in bacterial, yeast, and rodent systems and discuss their involvement in human disease. While some associations are already well understood, it is clear that additional diseases will be found which are linked to DNA repair defects or deficiencies. Environ. Mol. Mutagen. 33:3–20, 1999 © 1999 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1098-2280(1999)33:1<3::AID-EM2>3.0.CO;2-L |
| format | Article |
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Mol. Mutagen</addtitle><description>DNA repair systems act to maintain genome integrity in the face of replication errors, environmental insults, and the cumulative effects of age. More than 70 human genes directly involved in the five major pathways of DNA repair have been described, including chromosomal location and cDNA sequence. However, a great deal of information as to the precise functions of these genes and their role in human health is still lacking. Hence, we summarize what is known about these genes and their contra part in bacterial, yeast, and rodent systems and discuss their involvement in human disease. While some associations are already well understood, it is clear that additional diseases will be found which are linked to DNA repair defects or deficiencies. Environ. Mol. Mutagen. 33:3–20, 1999 © 1999 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Apoptosis - genetics</subject><subject>Base Pair Mismatch - genetics</subject><subject>Biological and medical sciences</subject><subject>cancer</subject><subject>Cell Cycle - genetics</subject><subject>Deoxyribodipyrimidine Photo-Lyase - genetics</subject><subject>DNA Fragmentation - genetics</subject><subject>DNA Glycosylases</subject><subject>DNA Repair</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>human disease</subject><subject>Humans</subject><subject>Molecular and cellular biology</subject><subject>molecular epidemiology</subject><subject>Molecular genetics</subject><subject>Mutagenesis. 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Psychology</topic><topic>human disease</topic><topic>Humans</topic><topic>Molecular and cellular biology</topic><topic>molecular epidemiology</topic><topic>Molecular genetics</topic><topic>Mutagenesis. 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Mol. Mutagen</addtitle><date>1999</date><risdate>1999</risdate><volume>33</volume><issue>1</issue><spage>3</spage><epage>20</epage><pages>3-20</pages><issn>0893-6692</issn><eissn>1098-2280</eissn><coden>EMMUEG</coden><abstract>DNA repair systems act to maintain genome integrity in the face of replication errors, environmental insults, and the cumulative effects of age. More than 70 human genes directly involved in the five major pathways of DNA repair have been described, including chromosomal location and cDNA sequence. However, a great deal of information as to the precise functions of these genes and their role in human health is still lacking. Hence, we summarize what is known about these genes and their contra part in bacterial, yeast, and rodent systems and discuss their involvement in human disease. While some associations are already well understood, it is clear that additional diseases will be found which are linked to DNA repair defects or deficiencies. Environ. Mol. 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| identifier | ISSN: 0893-6692 |
| ispartof | Environmental and molecular mutagenesis, 1999, Vol.33 (1), p.3-20 |
| issn | 0893-6692 1098-2280 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Animals Apoptosis - genetics Base Pair Mismatch - genetics Biological and medical sciences cancer Cell Cycle - genetics Deoxyribodipyrimidine Photo-Lyase - genetics DNA Fragmentation - genetics DNA Glycosylases DNA Repair Fundamental and applied biological sciences. Psychology human disease Humans Molecular and cellular biology molecular epidemiology Molecular genetics Mutagenesis. Repair mutation N-Glycosyl Hydrolases - genetics O-Methylguanine-DNA Methyltransferase - genetics |
| title | Human DNA repair systems: An overview |
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