Structural and functional macrophages alterations by ceramics of different composition
Biomaterials may initiate several and complex biological reactions in host tissues, and the cell–biomaterial interactions can determine the release of mediators including monocytes and lymphocytes chemotactic factors. The present work was aimed to investigate in vitro the macrophage biological react...
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| Veröffentlicht in: | Biomaterials 1999-02, Vol.20 (4), p.363-370 |
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| creator | Bosetti, M. Ottani, V. Kozel, D. Raspanti, M. De Pasquale, V. Ruggeri, A. Cannas, M. |
| description | Biomaterials may initiate several and complex biological reactions in host tissues, and the cell–biomaterial interactions can determine the release of mediators including monocytes and lymphocytes chemotactic factors. The present work was aimed to investigate in vitro the macrophage biological reactions of a natural apatite obtained by heat treatment at 400°C of bovine bone, compared to other ceramics usually used for dental and orthopedic applications, using synthetic apatite and three types of alumina as controls. Particles chemotactic activity and powders oxidative burst evidenced no monocyte–macrophages sensitivity reaction for natural and synthetic hydroxyapatite powders at great granulometry (>50
μm); data were confirmed by ultrastructural observations; electron microscopy analysis showed macrophages with the features of healthy cells in the presence of both natural and synthetic apatites while macrophages grown in the presence of alumina seemed to be negatively affected. In conclusion, among all ceramics tested, natural apatite displayed a good compatibility with living cells, being better tolerated than synthetic hydroxyapatite which in turn is better tolerated than alumina. |
| doi_str_mv | 10.1016/S0142-9612(98)00177-X |
| format | Article |
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μm); data were confirmed by ultrastructural observations; electron microscopy analysis showed macrophages with the features of healthy cells in the presence of both natural and synthetic apatites while macrophages grown in the presence of alumina seemed to be negatively affected. In conclusion, among all ceramics tested, natural apatite displayed a good compatibility with living cells, being better tolerated than synthetic hydroxyapatite which in turn is better tolerated than alumina.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/S0142-9612(98)00177-X</identifier><identifier>PMID: 10048409</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Alumina ; Aluminum Oxide - pharmacology ; Animals ; Apatite ; Apatites - chemical synthesis ; Apatites - pharmacology ; Biocompatibility ; Biocompatible Materials - pharmacology ; Biological and medical sciences ; Bone ; Cattle ; Ceramic materials ; Ceramics - chemistry ; Ceramics - pharmacology ; Chemotaxis, Leukocyte - drug effects ; Dental biomaterials ; Electron microscopy ; Heat treatment ; Humans ; Hydroxyapatites - pharmacology ; Luminescent Measurements ; Macrophages ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - physiology ; Macrophages, Peritoneal - ultrastructure ; Medical applications ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Monocytes - drug effects ; Monocytes - physiology ; Monocytes - ultrastructure ; Phosphate minerals ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Technology. Biomaterials. Equipments. Material. Instrumentation</subject><ispartof>Biomaterials, 1999-02, Vol.20 (4), p.363-370</ispartof><rights>1999 Elsevier Science Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-9cb41d9465695d2f5a9967e8ac0acda04f91390c0b94a8586646df69c13b18f93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S014296129800177X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1683707$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10048409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bosetti, M.</creatorcontrib><creatorcontrib>Ottani, V.</creatorcontrib><creatorcontrib>Kozel, D.</creatorcontrib><creatorcontrib>Raspanti, M.</creatorcontrib><creatorcontrib>De Pasquale, V.</creatorcontrib><creatorcontrib>Ruggeri, A.</creatorcontrib><creatorcontrib>Cannas, M.</creatorcontrib><title>Structural and functional macrophages alterations by ceramics of different composition</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Biomaterials may initiate several and complex biological reactions in host tissues, and the cell–biomaterial interactions can determine the release of mediators including monocytes and lymphocytes chemotactic factors. The present work was aimed to investigate in vitro the macrophage biological reactions of a natural apatite obtained by heat treatment at 400°C of bovine bone, compared to other ceramics usually used for dental and orthopedic applications, using synthetic apatite and three types of alumina as controls. Particles chemotactic activity and powders oxidative burst evidenced no monocyte–macrophages sensitivity reaction for natural and synthetic hydroxyapatite powders at great granulometry (>50
μm); data were confirmed by ultrastructural observations; electron microscopy analysis showed macrophages with the features of healthy cells in the presence of both natural and synthetic apatites while macrophages grown in the presence of alumina seemed to be negatively affected. In conclusion, among all ceramics tested, natural apatite displayed a good compatibility with living cells, being better tolerated than synthetic hydroxyapatite which in turn is better tolerated than alumina.</description><subject>Alumina</subject><subject>Aluminum Oxide - pharmacology</subject><subject>Animals</subject><subject>Apatite</subject><subject>Apatites - chemical synthesis</subject><subject>Apatites - pharmacology</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bone</subject><subject>Cattle</subject><subject>Ceramic materials</subject><subject>Ceramics - chemistry</subject><subject>Ceramics - pharmacology</subject><subject>Chemotaxis, Leukocyte - drug effects</subject><subject>Dental biomaterials</subject><subject>Electron microscopy</subject><subject>Heat treatment</subject><subject>Humans</subject><subject>Hydroxyapatites - pharmacology</subject><subject>Luminescent Measurements</subject><subject>Macrophages</subject><subject>Macrophages, Peritoneal - drug effects</subject><subject>Macrophages, Peritoneal - physiology</subject><subject>Macrophages, Peritoneal - ultrastructure</subject><subject>Medical applications</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - physiology</subject><subject>Monocytes - ultrastructure</subject><subject>Phosphate minerals</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Technology. Biomaterials. Equipments. Material. Instrumentation</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0cuKFTEQBuAginNm9BGUXoiMi9akO0mnVoMM3mDAxajMLlRXEo305Zh0C_P25lxQd2cVinxVFfIz9kzw14IL_eaWC9nUoEVzCeYV56Lr6rsHbCNMZ2oFXD1km7_kjJ3n_LMgyWXzmJ0JzqWRHDbs2-2SVlrWhEOFk6vCOtES56mUI1Katz_wu88VDotPuLvIVX9fUSnGSLmaQ-ViCD75aaloHrdzjjv1hD0KOGT_9HhesK_v3325_ljffP7w6frtTU1KwlID9VI4kFppUK4JCgF05w0SR3LIZQDRAifeg0SjjNZSu6CBRNsLE6C9YC8Pc7dp_rX6vNgxZvLDgJOf12zLWGi1bk_CBsqmpsiTsBOqAWlOQ9FKaPdQHWD5zpyTD3ab4ojp3gpud1nafZZ2F5QFY_dZ2rvS9_y4YO1H7_7rOoRXwIsjwEw4hIQTxfzPadN2vCvs6sB8CeJ39Mlmin4i72LytFg3xxMv-QMfV7t2</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>Bosetti, M.</creator><creator>Ottani, V.</creator><creator>Kozel, D.</creator><creator>Raspanti, M.</creator><creator>De Pasquale, V.</creator><creator>Ruggeri, A.</creator><creator>Cannas, M.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><scope>7QF</scope><scope>8BQ</scope><scope>7X8</scope></search><sort><creationdate>19990201</creationdate><title>Structural and functional macrophages alterations by ceramics of different composition</title><author>Bosetti, M. ; Ottani, V. ; Kozel, D. ; Raspanti, M. ; De Pasquale, V. ; Ruggeri, A. ; Cannas, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-9cb41d9465695d2f5a9967e8ac0acda04f91390c0b94a8586646df69c13b18f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Alumina</topic><topic>Aluminum Oxide - pharmacology</topic><topic>Animals</topic><topic>Apatite</topic><topic>Apatites - chemical synthesis</topic><topic>Apatites - pharmacology</topic><topic>Biocompatibility</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bone</topic><topic>Cattle</topic><topic>Ceramic materials</topic><topic>Ceramics - chemistry</topic><topic>Ceramics - pharmacology</topic><topic>Chemotaxis, Leukocyte - drug effects</topic><topic>Dental biomaterials</topic><topic>Electron microscopy</topic><topic>Heat treatment</topic><topic>Humans</topic><topic>Hydroxyapatites - pharmacology</topic><topic>Luminescent Measurements</topic><topic>Macrophages</topic><topic>Macrophages, Peritoneal - drug effects</topic><topic>Macrophages, Peritoneal - physiology</topic><topic>Macrophages, Peritoneal - ultrastructure</topic><topic>Medical applications</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Monocytes - drug effects</topic><topic>Monocytes - physiology</topic><topic>Monocytes - ultrastructure</topic><topic>Phosphate minerals</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Technology. Biomaterials. Equipments. Material. Instrumentation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bosetti, M.</creatorcontrib><creatorcontrib>Ottani, V.</creatorcontrib><creatorcontrib>Kozel, D.</creatorcontrib><creatorcontrib>Raspanti, M.</creatorcontrib><creatorcontrib>De Pasquale, V.</creatorcontrib><creatorcontrib>Ruggeri, A.</creatorcontrib><creatorcontrib>Cannas, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Aluminium Industry Abstracts</collection><collection>METADEX</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bosetti, M.</au><au>Ottani, V.</au><au>Kozel, D.</au><au>Raspanti, M.</au><au>De Pasquale, V.</au><au>Ruggeri, A.</au><au>Cannas, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural and functional macrophages alterations by ceramics of different composition</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>20</volume><issue>4</issue><spage>363</spage><epage>370</epage><pages>363-370</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Biomaterials may initiate several and complex biological reactions in host tissues, and the cell–biomaterial interactions can determine the release of mediators including monocytes and lymphocytes chemotactic factors. The present work was aimed to investigate in vitro the macrophage biological reactions of a natural apatite obtained by heat treatment at 400°C of bovine bone, compared to other ceramics usually used for dental and orthopedic applications, using synthetic apatite and three types of alumina as controls. Particles chemotactic activity and powders oxidative burst evidenced no monocyte–macrophages sensitivity reaction for natural and synthetic hydroxyapatite powders at great granulometry (>50
μm); data were confirmed by ultrastructural observations; electron microscopy analysis showed macrophages with the features of healthy cells in the presence of both natural and synthetic apatites while macrophages grown in the presence of alumina seemed to be negatively affected. In conclusion, among all ceramics tested, natural apatite displayed a good compatibility with living cells, being better tolerated than synthetic hydroxyapatite which in turn is better tolerated than alumina.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>10048409</pmid><doi>10.1016/S0142-9612(98)00177-X</doi><tpages>8</tpages></addata></record> |
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| subjects | Alumina Aluminum Oxide - pharmacology Animals Apatite Apatites - chemical synthesis Apatites - pharmacology Biocompatibility Biocompatible Materials - pharmacology Biological and medical sciences Bone Cattle Ceramic materials Ceramics - chemistry Ceramics - pharmacology Chemotaxis, Leukocyte - drug effects Dental biomaterials Electron microscopy Heat treatment Humans Hydroxyapatites - pharmacology Luminescent Measurements Macrophages Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - physiology Macrophages, Peritoneal - ultrastructure Medical applications Medical sciences Mice Mice, Inbred BALB C Monocytes - drug effects Monocytes - physiology Monocytes - ultrastructure Phosphate minerals Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Technology. Biomaterials. Equipments. Material. Instrumentation |
| title | Structural and functional macrophages alterations by ceramics of different composition |
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