Formation of N-methylnicotinamide in the brain from a dihydropyridine-type prodrug : Effect on brain choline

The enhancement of brain choline levels is a possible therapeutic option in neurodegenerative diseases; however, brain choline levels are held within narrow limits by homeostatic mechanisms including the rapid clearance of excess choline from the brain. The present study tests whether N-methylnicoti...

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Veröffentlicht in:	Biochemical pharmacology 1999-03, Vol.57 (6), p.681-684
Hauptverfasser:	Erb, Christina, Seidel, Albrecht, Frank, Heinz, Platt, Karl L, Oesch, Franz, Klein, Jochen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - drug effects Brain - metabolism brain targeting choline Choline - blood Choline - cerebrospinal fluid Cholinergic system Chromatography, High Pressure Liquid Dihydropyridines - pharmacology hippocampus Liver - metabolism Male Medical sciences Microdialysis N-methylnicotinamide Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Niacinamide - analogs & derivatives Niacinamide - biosynthesis Niacinamide - blood Niacinamide - cerebrospinal fluid Niacinamide - chemical synthesis Niacinamide - pharmacology nicotinamide Pharmacology. Drug treatments Prodrugs - pharmacology Rats Rats, Wistar
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