Is the aortic root dilated in obstructive sleep apnoea syndrome?
Summary Background Obstructive sleep apnoea syndrome (OSAS) is associated with an increased risk of arterial hypertension (AH), coronary artery disease, atrial arrhythmias, heart failure, stroke and death. Whether OSAS influences aortic root size has not been fully investigated. The aim of our study...
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| Veröffentlicht in: | Archives of cardiovascular diseases 2008-06, Vol.101 (6), p.391-397 |
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| creator | Meuleman, Catherine Boccara, Franck Nguyen, Xuan-Lan Di Angelantonio, Emanuele Ederhy, Stéphane Janower, Sandra Dufaitre, Ghislaine Haddour, Nabila Boyer-Chatenet, Louise Rakotonanahary, Dominique Fleury, Bernard Cohen, Ariel |
| description | Summary Background Obstructive sleep apnoea syndrome (OSAS) is associated with an increased risk of arterial hypertension (AH), coronary artery disease, atrial arrhythmias, heart failure, stroke and death. Whether OSAS influences aortic root size has not been fully investigated. The aim of our study was to investigate aortic root diameter and aortic stiffness in OSAS. Methods Using transthoracic Doppler echocardiography, we evaluated 76 patients with OSAS (mean age 52.7 ± 9.5 years, 70 men [92%]) with no overt cardiovascular disease. The following parameters were measured offline: aortic diameter at Valsalva sinuses, aortic regurgitation (AR) grade, left ventricular (LV) mass, LV ejection fraction (LVEF, Simpson rule), systolic pulmonary artery pressure (sPAP). Aortic stiffness (carotid-femoral pulse wave velocity, PWV) was measured non-invasively using SphygmoCor technology. Results Mean duration of OSAS was four years and 84% of patients were being treated with continuous positive airway pressure. AH was documented in 39 (51%) patients. The mean aortic root diameter was 35.3 ± 3.8 mm (26.9–44.6 mm) and the prevalence of aortic root dilatation was 3.9% (3 of 76 patients). On univariate analysis, age and sex were significant predictors of aortic root dilatation whereas arterial hypertension was not. Conclusions The prevalence of aortic root enlargement was not increased in OSAS. Only age and sex and not arterial hypertension, were associated with aortic dilatation. |
| doi_str_mv | 10.1016/j.acvd.2008.06.007 |
| format | Article |
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Whether OSAS influences aortic root size has not been fully investigated. The aim of our study was to investigate aortic root diameter and aortic stiffness in OSAS. Methods Using transthoracic Doppler echocardiography, we evaluated 76 patients with OSAS (mean age 52.7 ± 9.5 years, 70 men [92%]) with no overt cardiovascular disease. The following parameters were measured offline: aortic diameter at Valsalva sinuses, aortic regurgitation (AR) grade, left ventricular (LV) mass, LV ejection fraction (LVEF, Simpson rule), systolic pulmonary artery pressure (sPAP). Aortic stiffness (carotid-femoral pulse wave velocity, PWV) was measured non-invasively using SphygmoCor technology. Results Mean duration of OSAS was four years and 84% of patients were being treated with continuous positive airway pressure. AH was documented in 39 (51%) patients. The mean aortic root diameter was 35.3 ± 3.8 mm (26.9–44.6 mm) and the prevalence of aortic root dilatation was 3.9% (3 of 76 patients). On univariate analysis, age and sex were significant predictors of aortic root dilatation whereas arterial hypertension was not. Conclusions The prevalence of aortic root enlargement was not increased in OSAS. Only age and sex and not arterial hypertension, were associated with aortic dilatation.</description><identifier>ISSN: 1875-2136</identifier><identifier>EISSN: 1875-2128</identifier><identifier>DOI: 10.1016/j.acvd.2008.06.007</identifier><identifier>PMID: 18809152</identifier><language>eng</language><publisher>Netherlands: Elsevier Masson SAS</publisher><subject>Adult ; Age Factors ; Aorta - diagnostic imaging ; Aorta - pathology ; Aorta - physiopathology ; Aortic root dilatation ; Cardiovascular ; Carotid Arteries - diagnostic imaging ; Carotid Arteries - physiopathology ; Cohort Studies ; Dilatation aortique ; Dilatation, Pathologic - complications ; Dilatation, Pathologic - physiopathology ; Echocardiography, Doppler ; Elasticity ; Humans ; Internal Medicine ; Male ; Middle Aged ; Obstructive sleep apnoea syndrome ; Polysomnography - methods ; Pulsatile Flow ; Pulse wave velocity ; Retrospective Studies ; Sex Factors ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - diagnostic imaging ; Sleep Apnea, Obstructive - pathology ; Sleep Apnea, Obstructive - physiopathology ; Syndrome d’apnée obstructive du sommeil ; Vitesse de l’onde de pouls</subject><ispartof>Archives of cardiovascular diseases, 2008-06, Vol.101 (6), p.391-397</ispartof><rights>2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-341b8641a37b9fe36bd4f1735b5d7c41a7324252c7c35c9b70b7e78e159021e13</citedby><cites>FETCH-LOGICAL-c409t-341b8641a37b9fe36bd4f1735b5d7c41a7324252c7c35c9b70b7e78e159021e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1875213608000727$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18809152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meuleman, Catherine</creatorcontrib><creatorcontrib>Boccara, Franck</creatorcontrib><creatorcontrib>Nguyen, Xuan-Lan</creatorcontrib><creatorcontrib>Di Angelantonio, Emanuele</creatorcontrib><creatorcontrib>Ederhy, Stéphane</creatorcontrib><creatorcontrib>Janower, Sandra</creatorcontrib><creatorcontrib>Dufaitre, Ghislaine</creatorcontrib><creatorcontrib>Haddour, Nabila</creatorcontrib><creatorcontrib>Boyer-Chatenet, Louise</creatorcontrib><creatorcontrib>Rakotonanahary, Dominique</creatorcontrib><creatorcontrib>Fleury, Bernard</creatorcontrib><creatorcontrib>Cohen, Ariel</creatorcontrib><title>Is the aortic root dilated in obstructive sleep apnoea syndrome?</title><title>Archives of cardiovascular diseases</title><addtitle>Arch Cardiovasc Dis</addtitle><description>Summary Background Obstructive sleep apnoea syndrome (OSAS) is associated with an increased risk of arterial hypertension (AH), coronary artery disease, atrial arrhythmias, heart failure, stroke and death. Whether OSAS influences aortic root size has not been fully investigated. The aim of our study was to investigate aortic root diameter and aortic stiffness in OSAS. Methods Using transthoracic Doppler echocardiography, we evaluated 76 patients with OSAS (mean age 52.7 ± 9.5 years, 70 men [92%]) with no overt cardiovascular disease. The following parameters were measured offline: aortic diameter at Valsalva sinuses, aortic regurgitation (AR) grade, left ventricular (LV) mass, LV ejection fraction (LVEF, Simpson rule), systolic pulmonary artery pressure (sPAP). Aortic stiffness (carotid-femoral pulse wave velocity, PWV) was measured non-invasively using SphygmoCor technology. Results Mean duration of OSAS was four years and 84% of patients were being treated with continuous positive airway pressure. AH was documented in 39 (51%) patients. The mean aortic root diameter was 35.3 ± 3.8 mm (26.9–44.6 mm) and the prevalence of aortic root dilatation was 3.9% (3 of 76 patients). On univariate analysis, age and sex were significant predictors of aortic root dilatation whereas arterial hypertension was not. Conclusions The prevalence of aortic root enlargement was not increased in OSAS. Only age and sex and not arterial hypertension, were associated with aortic dilatation.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aorta - diagnostic imaging</subject><subject>Aorta - pathology</subject><subject>Aorta - physiopathology</subject><subject>Aortic root dilatation</subject><subject>Cardiovascular</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Arteries - physiopathology</subject><subject>Cohort Studies</subject><subject>Dilatation aortique</subject><subject>Dilatation, Pathologic - complications</subject><subject>Dilatation, Pathologic - physiopathology</subject><subject>Echocardiography, Doppler</subject><subject>Elasticity</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obstructive sleep apnoea syndrome</subject><subject>Polysomnography - methods</subject><subject>Pulsatile Flow</subject><subject>Pulse wave velocity</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - diagnostic imaging</subject><subject>Sleep Apnea, Obstructive - pathology</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>Syndrome d’apnée obstructive du sommeil</subject><subject>Vitesse de l’onde de pouls</subject><issn>1875-2136</issn><issn>1875-2128</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtr5DAQhEVI2Dx2_0AOQafcxmlJtmRDyIOweUAgh909C1nqIZp4rIkkD8y_X5sZEsghp26aqoL-ipBTBgUDJi8WhbFrV3CAugBZAKg9csRqVc044_X-xy7kITlOaQEguVLyBzlkdQ0Nq_gRuXlKNL8iNSFmb2kMIVPnO5PRUd_T0KYcB5v9GmnqEFfUrPqAhqZN72JY4vVPcjA3XcJfu3lC_t3__nv3OHt-eXi6u32e2RKaPBMla2tZMiNU28xRyNaVc6ZE1VZO2fGuBC95xa2yorJNq6BVqGpkVQOcIRMn5Hybu4rhfcCU9dIni11negxD0rKpGiYUjEK-FdoYUoo416volyZuNAM9cdMLPXHTEzcNUo_cRtPZLn1ol-g-LTtQo-ByK8Dxx7XHqJP12Ft0PqLN2gX_ff7VF7vtfO-t6d5wg2kRhtiP9DTTiWvQf6bmpuKghtHOlfgPGbCSIw</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Meuleman, Catherine</creator><creator>Boccara, Franck</creator><creator>Nguyen, Xuan-Lan</creator><creator>Di Angelantonio, Emanuele</creator><creator>Ederhy, Stéphane</creator><creator>Janower, Sandra</creator><creator>Dufaitre, Ghislaine</creator><creator>Haddour, Nabila</creator><creator>Boyer-Chatenet, Louise</creator><creator>Rakotonanahary, Dominique</creator><creator>Fleury, Bernard</creator><creator>Cohen, Ariel</creator><general>Elsevier Masson SAS</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Is the aortic root dilated in obstructive sleep apnoea syndrome?</title><author>Meuleman, Catherine ; Boccara, Franck ; Nguyen, Xuan-Lan ; Di Angelantonio, Emanuele ; Ederhy, Stéphane ; Janower, Sandra ; Dufaitre, Ghislaine ; Haddour, Nabila ; Boyer-Chatenet, Louise ; Rakotonanahary, Dominique ; Fleury, Bernard ; Cohen, Ariel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-341b8641a37b9fe36bd4f1735b5d7c41a7324252c7c35c9b70b7e78e159021e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aorta - diagnostic imaging</topic><topic>Aorta - pathology</topic><topic>Aorta - physiopathology</topic><topic>Aortic root dilatation</topic><topic>Cardiovascular</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Arteries - physiopathology</topic><topic>Cohort Studies</topic><topic>Dilatation aortique</topic><topic>Dilatation, Pathologic - complications</topic><topic>Dilatation, Pathologic - physiopathology</topic><topic>Echocardiography, Doppler</topic><topic>Elasticity</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obstructive sleep apnoea syndrome</topic><topic>Polysomnography - methods</topic><topic>Pulsatile Flow</topic><topic>Pulse wave velocity</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - diagnostic imaging</topic><topic>Sleep Apnea, Obstructive - pathology</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>Syndrome d’apnée obstructive du sommeil</topic><topic>Vitesse de l’onde de pouls</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meuleman, Catherine</creatorcontrib><creatorcontrib>Boccara, Franck</creatorcontrib><creatorcontrib>Nguyen, Xuan-Lan</creatorcontrib><creatorcontrib>Di Angelantonio, Emanuele</creatorcontrib><creatorcontrib>Ederhy, Stéphane</creatorcontrib><creatorcontrib>Janower, Sandra</creatorcontrib><creatorcontrib>Dufaitre, Ghislaine</creatorcontrib><creatorcontrib>Haddour, Nabila</creatorcontrib><creatorcontrib>Boyer-Chatenet, Louise</creatorcontrib><creatorcontrib>Rakotonanahary, Dominique</creatorcontrib><creatorcontrib>Fleury, Bernard</creatorcontrib><creatorcontrib>Cohen, Ariel</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meuleman, Catherine</au><au>Boccara, Franck</au><au>Nguyen, Xuan-Lan</au><au>Di Angelantonio, Emanuele</au><au>Ederhy, Stéphane</au><au>Janower, Sandra</au><au>Dufaitre, Ghislaine</au><au>Haddour, Nabila</au><au>Boyer-Chatenet, Louise</au><au>Rakotonanahary, Dominique</au><au>Fleury, Bernard</au><au>Cohen, Ariel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is the aortic root dilated in obstructive sleep apnoea syndrome?</atitle><jtitle>Archives of cardiovascular diseases</jtitle><addtitle>Arch Cardiovasc Dis</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>101</volume><issue>6</issue><spage>391</spage><epage>397</epage><pages>391-397</pages><issn>1875-2136</issn><eissn>1875-2128</eissn><abstract>Summary Background Obstructive sleep apnoea syndrome (OSAS) is associated with an increased risk of arterial hypertension (AH), coronary artery disease, atrial arrhythmias, heart failure, stroke and death. Whether OSAS influences aortic root size has not been fully investigated. The aim of our study was to investigate aortic root diameter and aortic stiffness in OSAS. Methods Using transthoracic Doppler echocardiography, we evaluated 76 patients with OSAS (mean age 52.7 ± 9.5 years, 70 men [92%]) with no overt cardiovascular disease. The following parameters were measured offline: aortic diameter at Valsalva sinuses, aortic regurgitation (AR) grade, left ventricular (LV) mass, LV ejection fraction (LVEF, Simpson rule), systolic pulmonary artery pressure (sPAP). Aortic stiffness (carotid-femoral pulse wave velocity, PWV) was measured non-invasively using SphygmoCor technology. Results Mean duration of OSAS was four years and 84% of patients were being treated with continuous positive airway pressure. AH was documented in 39 (51%) patients. The mean aortic root diameter was 35.3 ± 3.8 mm (26.9–44.6 mm) and the prevalence of aortic root dilatation was 3.9% (3 of 76 patients). On univariate analysis, age and sex were significant predictors of aortic root dilatation whereas arterial hypertension was not. Conclusions The prevalence of aortic root enlargement was not increased in OSAS. Only age and sex and not arterial hypertension, were associated with aortic dilatation.</abstract><cop>Netherlands</cop><pub>Elsevier Masson SAS</pub><pmid>18809152</pmid><doi>10.1016/j.acvd.2008.06.007</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Factors Aorta - diagnostic imaging Aorta - pathology Aorta - physiopathology Aortic root dilatation Cardiovascular Carotid Arteries - diagnostic imaging Carotid Arteries - physiopathology Cohort Studies Dilatation aortique Dilatation, Pathologic - complications Dilatation, Pathologic - physiopathology Echocardiography, Doppler Elasticity Humans Internal Medicine Male Middle Aged Obstructive sleep apnoea syndrome Polysomnography - methods Pulsatile Flow Pulse wave velocity Retrospective Studies Sex Factors Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - diagnostic imaging Sleep Apnea, Obstructive - pathology Sleep Apnea, Obstructive - physiopathology Syndrome d’apnée obstructive du sommeil Vitesse de l’onde de pouls |
| title | Is the aortic root dilated in obstructive sleep apnoea syndrome? |
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