Functional Gene Polymorphisms in Canadian Aboriginal Populations with High Rates of Tuberculosis
The present study determined whether a pattern of functional single-nucleotide polymorphisms (SNPs) was present that could predispose a Dené cohort to a suboptimal response to Mycobacterium tuberculosis. Compared with a Caucasian cohort, the Dené and Cree were found to maintain a significantly highe...
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| Veröffentlicht in: | The Journal of infectious diseases 2008-10, Vol.198 (8), p.1175-1179 |
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| container_title | The Journal of infectious diseases |
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| creator | Larcombe, Linda Orr, Pamela H. Lodge, Andrew M. Brown, Jodie S. Dembinski, Iga J. Milligan, Leisel C. Larcombe, Erin A. Martin, Bruce D. Nickerson, Peter W. |
| description | The present study determined whether a pattern of functional single-nucleotide polymorphisms (SNPs) was present that could predispose a Dené cohort to a suboptimal response to Mycobacterium tuberculosis. Compared with a Caucasian cohort, the Dené and Cree were found to maintain a significantly higher frequency of SNPs associated with low expression of vitamin D receptor (VDR), interferon (IFN)-γ (+874), and tumor necrosis factor-α (-308) and high production of monocyte chemoattractant protein (MCP)-1 (-2518) and interleukin (IL)-6(-174). Given the roles played by IFN-γ and VDR in facilitating macrophage containment of M. tuberculosis and the opposing role of MCP-1 and IL-6, the observed allelic variation by ethnicity may in part contribute to the high rates of tuberculosis among the Dené. |
| doi_str_mv | 10.1086/592049 |
| format | Article |
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Compared with a Caucasian cohort, the Dené and Cree were found to maintain a significantly higher frequency of SNPs associated with low expression of vitamin D receptor (VDR), interferon (IFN)-γ (+874), and tumor necrosis factor-α (-308) and high production of monocyte chemoattractant protein (MCP)-1 (-2518) and interleukin (IL)-6(-174). Given the roles played by IFN-γ and VDR in facilitating macrophage containment of M. tuberculosis and the opposing role of MCP-1 and IL-6, the observed allelic variation by ethnicity may in part contribute to the high rates of tuberculosis among the Dené.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/592049</identifier><identifier>PMID: 18713057</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Alleles ; Bacteria ; Bacterial diseases ; Biological and medical sciences ; Canada - epidemiology ; Canada - ethnology ; Central nervous system tuberculosis ; Cytokines - genetics ; European Continental Ancestry Group ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Human bacterial diseases ; Humans ; Indians, North American - genetics ; Infectious diseases ; Macrophages ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - pathogenicity ; Polymorphism, Single Nucleotide ; Population genetics ; Pulmonary tuberculosis ; Receptors ; Receptors, Calcitriol - genetics ; Tuberculosis ; Tuberculosis - epidemiology ; Tuberculosis - ethnology ; Tuberculosis - genetics ; Tuberculosis and atypical mycobacterial infections ; Vitamin D ; White people</subject><ispartof>The Journal of infectious diseases, 2008-10, Vol.198 (8), p.1175-1179</ispartof><rights>Copyright 2008 Infectious Diseases Society of America</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-a03e8bc5b62cfee5f6b4fedc7be15d80487a9475e7231cad4be771ba975cdbe63</citedby><cites>FETCH-LOGICAL-c398t-a03e8bc5b62cfee5f6b4fedc7be15d80487a9475e7231cad4be771ba975cdbe63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40254254$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40254254$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20714649$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18713057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Larcombe, Linda</creatorcontrib><creatorcontrib>Orr, Pamela H.</creatorcontrib><creatorcontrib>Lodge, Andrew M.</creatorcontrib><creatorcontrib>Brown, Jodie S.</creatorcontrib><creatorcontrib>Dembinski, Iga J.</creatorcontrib><creatorcontrib>Milligan, Leisel C.</creatorcontrib><creatorcontrib>Larcombe, Erin A.</creatorcontrib><creatorcontrib>Martin, Bruce D.</creatorcontrib><creatorcontrib>Nickerson, Peter W.</creatorcontrib><title>Functional Gene Polymorphisms in Canadian Aboriginal Populations with High Rates of Tuberculosis</title><title>The Journal of infectious diseases</title><addtitle>Journal of Infectious Diseases</addtitle><description>The present study determined whether a pattern of functional single-nucleotide polymorphisms (SNPs) was present that could predispose a Dené cohort to a suboptimal response to Mycobacterium tuberculosis. Compared with a Caucasian cohort, the Dené and Cree were found to maintain a significantly higher frequency of SNPs associated with low expression of vitamin D receptor (VDR), interferon (IFN)-γ (+874), and tumor necrosis factor-α (-308) and high production of monocyte chemoattractant protein (MCP)-1 (-2518) and interleukin (IL)-6(-174). Given the roles played by IFN-γ and VDR in facilitating macrophage containment of M. tuberculosis and the opposing role of MCP-1 and IL-6, the observed allelic variation by ethnicity may in part contribute to the high rates of tuberculosis among the Dené.</description><subject>Adult</subject><subject>Alleles</subject><subject>Bacteria</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Canada - epidemiology</subject><subject>Canada - ethnology</subject><subject>Central nervous system tuberculosis</subject><subject>Cytokines - genetics</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Indians, North American - genetics</subject><subject>Infectious diseases</subject><subject>Macrophages</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - pathogenicity</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population genetics</subject><subject>Pulmonary tuberculosis</subject><subject>Receptors</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Tuberculosis</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - ethnology</subject><subject>Tuberculosis - genetics</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Vitamin D</subject><subject>White people</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EFv0zAYBmALgVgZ8A9AvsAtYMexHR-njq6IISYYAnExtvNl9Uji4i8R7N-T0qockSz58D7fe3gJecrZK85q9VqaklXmHllwKXShFBf3yYKxsix4bcwJeYR4yxirhNIPyQmvNRdM6gX5vpqGMMY0uI5ewAD0KnV3fcrbTcQeaRzo0g2uiW6gZz7leBN38iptp87tzpD-iuOGruPNhn50IyBNLb2ePOQwdQkjPiYPWtchPDn8p-Tz6s31cl1cfrh4uzy7LIIw9Vg4JqD2QXpVhhZAtspXLTRBe-CyqVlVa2cqLUGXggfXVB605t4ZLUPjQYlT8nLfu83p5wQ42j5igK5zA6QJrTLSMMb5fyE3mtdyXuoIQ06IGVq7zbF3-c5yZnej2_3oM3x-aJx8D80_dlh5Bi8OwGFwXZvdECIeXck0r9Tfomd7d4tjyse8YqWs5jfnxT6POMLvY-7yD6u00NKuv36zK33-Tn1SX-x78QcUu6Kb</recordid><startdate>20081015</startdate><enddate>20081015</enddate><creator>Larcombe, Linda</creator><creator>Orr, Pamela H.</creator><creator>Lodge, Andrew M.</creator><creator>Brown, Jodie S.</creator><creator>Dembinski, Iga J.</creator><creator>Milligan, Leisel C.</creator><creator>Larcombe, Erin A.</creator><creator>Martin, Bruce D.</creator><creator>Nickerson, Peter W.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20081015</creationdate><title>Functional Gene Polymorphisms in Canadian Aboriginal Populations with High Rates of Tuberculosis</title><author>Larcombe, Linda ; Orr, Pamela H. ; Lodge, Andrew M. ; Brown, Jodie S. ; Dembinski, Iga J. ; Milligan, Leisel C. ; Larcombe, Erin A. ; Martin, Bruce D. ; Nickerson, Peter W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-a03e8bc5b62cfee5f6b4fedc7be15d80487a9475e7231cad4be771ba975cdbe63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Bacteria</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Canada - epidemiology</topic><topic>Canada - ethnology</topic><topic>Central nervous system tuberculosis</topic><topic>Cytokines - genetics</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Indians, North American - genetics</topic><topic>Infectious diseases</topic><topic>Macrophages</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - pathogenicity</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population genetics</topic><topic>Pulmonary tuberculosis</topic><topic>Receptors</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Tuberculosis</topic><topic>Tuberculosis - epidemiology</topic><topic>Tuberculosis - ethnology</topic><topic>Tuberculosis - genetics</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Vitamin D</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Larcombe, Linda</creatorcontrib><creatorcontrib>Orr, Pamela H.</creatorcontrib><creatorcontrib>Lodge, Andrew M.</creatorcontrib><creatorcontrib>Brown, Jodie S.</creatorcontrib><creatorcontrib>Dembinski, Iga J.</creatorcontrib><creatorcontrib>Milligan, Leisel C.</creatorcontrib><creatorcontrib>Larcombe, Erin A.</creatorcontrib><creatorcontrib>Martin, Bruce D.</creatorcontrib><creatorcontrib>Nickerson, Peter W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Larcombe, Linda</au><au>Orr, Pamela H.</au><au>Lodge, Andrew M.</au><au>Brown, Jodie S.</au><au>Dembinski, Iga J.</au><au>Milligan, Leisel C.</au><au>Larcombe, Erin A.</au><au>Martin, Bruce D.</au><au>Nickerson, Peter W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional Gene Polymorphisms in Canadian Aboriginal Populations with High Rates of Tuberculosis</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>Journal of Infectious Diseases</addtitle><date>2008-10-15</date><risdate>2008</risdate><volume>198</volume><issue>8</issue><spage>1175</spage><epage>1179</epage><pages>1175-1179</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The present study determined whether a pattern of functional single-nucleotide polymorphisms (SNPs) was present that could predispose a Dené cohort to a suboptimal response to Mycobacterium tuberculosis. Compared with a Caucasian cohort, the Dené and Cree were found to maintain a significantly higher frequency of SNPs associated with low expression of vitamin D receptor (VDR), interferon (IFN)-γ (+874), and tumor necrosis factor-α (-308) and high production of monocyte chemoattractant protein (MCP)-1 (-2518) and interleukin (IL)-6(-174). Given the roles played by IFN-γ and VDR in facilitating macrophage containment of M. tuberculosis and the opposing role of MCP-1 and IL-6, the observed allelic variation by ethnicity may in part contribute to the high rates of tuberculosis among the Dené.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>18713057</pmid><doi>10.1086/592049</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Alleles Bacteria Bacterial diseases Biological and medical sciences Canada - epidemiology Canada - ethnology Central nervous system tuberculosis Cytokines - genetics European Continental Ancestry Group Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Human bacterial diseases Humans Indians, North American - genetics Infectious diseases Macrophages Male Medical sciences Microbiology Middle Aged Mycobacterium tuberculosis Mycobacterium tuberculosis - pathogenicity Polymorphism, Single Nucleotide Population genetics Pulmonary tuberculosis Receptors Receptors, Calcitriol - genetics Tuberculosis Tuberculosis - epidemiology Tuberculosis - ethnology Tuberculosis - genetics Tuberculosis and atypical mycobacterial infections Vitamin D White people |
| title | Functional Gene Polymorphisms in Canadian Aboriginal Populations with High Rates of Tuberculosis |
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