Induction of cell cycle arrest and apoptosis in myeloma cells by cepharanthine, a biscoclaurine alkaloid

Cepharanthine (CEP), a biscoclaurine alkaloid extracted from Stephania Cepharantha Hayata, has been used in Japan for treating patients with radiation-induced leucopenia or thrombocytopenia. We treated a patient with multiple myeloma (MM), who was not responding to preceding chemotherapy, who coinci...

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Veröffentlicht in:	International journal of oncology 2008-10, Vol.33 (4), p.807-814
Hauptverfasser:	KIKUKAWA, Yoshitaka, OKUNO, Yutaka, TATETSU, Hiro, NAKAMURA, Miki, HARADA, Naoko, UENO, Shikiko, KAMIZAKI, Yorinori, MITSUYA, Hiroaki, HATA, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alkaloids - chemistry Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Benzylisoquinolines - pharmacology Biological and medical sciences Caspases - metabolism Cell Cycle - drug effects Cell Line, Tumor Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Female Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Medical sciences Multiple Myeloma - drug therapy Multiple Myeloma - metabolism Multiple Myeloma - pathology Prognosis Reactive Oxygen Species Tumors
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