Recruitment of the Retinoblastoma Protein to c-Jun Enhances Transcription Activity Mediated through the AP-1 Binding Site

The retinoblastoma susceptibility gene product (RB) is a transcriptional modulator. One of the targets for this modulator effect is the AP-1 binding site within the c- jun and collagenase promoters. The physical interactions between RB and c-Jun were demonstrated by co-immunoprecipitation of these t...

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