TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons

TAK-147, a potent acetylcholinesterase (AChE) inhibitor, potentiated choline acetyltransferase (ChAT) activity in cultured rat septal cholinergic neurons in a concentration-dependent manner with an EC 50 value of 4.47 nM. Donepezil, another potent AChE inhibitor, also increased ChAT activity althoug...

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Veröffentlicht in:	Neuroscience letters 1999-01, Vol.260 (1), p.5-8
Hauptverfasser:	Kato, Koki, Hayako, Hitomi, Ishihara, Yuji, Marui, Shogo, Iwane, Makoto, Miyamoto, Masaomi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase inhibitor Animals Benzazepines - pharmacology Biochemistry and metabolism Biological and medical sciences Cells, Cultured Central nervous system Choline acetyltransferase Choline O-Acetyltransferase - metabolism Cholinergic Fibers - enzymology Cholinesterase Inhibitors - pharmacology Donepezil Dose-Response Relationship, Drug Fetus - enzymology Fundamental and applied biological sciences. Psychology Nerve Growth Factors - pharmacology NGF Rats Rats, Sprague-Dawley Septal neurons Septal Nuclei - cytology Septal Nuclei - drug effects Septal Nuclei - enzymology TAK-147 Vertebrates: nervous system and sense organs σ Ligand
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