No pathogenic mutations in the persyn gene in Parkinson's disease

The persyn ( γ-synuclein) gene is highly homologous to the α-synuclein gene and is highly expressed in the nervous system. It is therefore, an excellent candidate gene for Parkinson's disease. However, we have sequenced the gene in a large number of families with parkinsonism and failed to find...

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Veröffentlicht in:	Neuroscience letters 1999-01, Vol.259 (1), p.65-66
Hauptverfasser:	Lincoln, Sarah, Gwinn-Hardy, Katrina, Goudreau, John, Christine Chartier-Harlin, Marie, Baker, Matt, Mouroux, Vincent, Richard, Florence, Destée, Alain, Becquet, Estelle, Amouyel, Philippe, Lynch, Tim, Hardy, John, Farrer, Matt
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Aged Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases gamma-Synuclein Genetics Humans Medical sciences Middle Aged Mutation - genetics Neoplasm Proteins Nerve Tissue Proteins - genetics Neurology Parkinson Disease - etiology Parkinson Disease - genetics Parkinson's disease Persyn Sequence Analysis, DNA - methods α-Synuclein
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