MEPE‐ASARM Peptides Control Extracellular Matrix Mineralization by Binding to Hydroxyapatite: An Inhibition Regulated by PHEX Cleavage of ASARM

Hyp mice having an inactivating mutation of the phosphate‐regulating gene with homologies to endopeptidases on the X‐chromosome (Phex) gene have bones with increased matrix extracellular phosphoglycoprotein (MEPE). An acidic, serine‐ and aspartic acid–rich motif (ASARM) is located in the C terminus...

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Veröffentlicht in:	Journal of bone and mineral research 2008-10, Vol.23 (10), p.1638-1649
Hauptverfasser:	Addison, William N, Nakano, Yukiko, Loisel, Thomas, Crine, Phillippe, McKee, Marc D
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells acidic Amino Acid Sequence Animals Biological and medical sciences biomineralization Durapatite - metabolism Extracellular Matrix - metabolism Extracellular Matrix Proteins - metabolism Extracellular Matrix Proteins - physiology Fundamental and applied biological sciences. Psychology Glycoproteins - metabolism Glycoproteins - physiology Hydrolysis Immunohistochemistry matrix extracellular phosphoglycoprotein Mice Molecular Sequence Data PHEX Phosphate Regulating Neutral Endopeptidase - metabolism phosphate‐regulating gene with homologies to endopeptidases on the X‐chromosome Phosphoproteins - metabolism Phosphoproteins - physiology Phosphorylation Protein Binding Reverse Transcriptase Polymerase Chain Reaction serine‐ and aspartic acid–rich motif peptides Skeleton and joints Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Vertebrates: osteoarticular system, musculoskeletal system X‐linked hypophosphatemia
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