Prevalence of Different Gadolinium Enhancement Patterns in Patients After Heart Transplantation
Prevalence of Different Gadolinium Enhancement Patterns in Patients After Heart Transplantation Henning Steen, Constanze Merten, Sonja Refle, Roland Klingenberg, Thomas Dengler, Evangelos Giannitsis, Hugo A. Katus Coronary angiography, which is routinely used for estimation of heart transplant (HTX)...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2008-09, Vol.52 (14), p.1160-1167 |
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| creator | Steen, Henning, MD Merten, Constanze, MD Refle, Sonja, MD Klingenberg, Roland, MD Dengler, Thomas, MD Giannitsis, Evangelos, MD Katus, Hugo A., MD |
| description | Prevalence of Different Gadolinium Enhancement Patterns in Patients After Heart Transplantation Henning Steen, Constanze Merten, Sonja Refle, Roland Klingenberg, Thomas Dengler, Evangelos Giannitsis, Hugo A. Katus Coronary angiography, which is routinely used for estimation of heart transplant (HTX) coronary artery disease (TCAD; I = mild; II = 30% to 75%, III = ≥75% stenosis), underestimates the intramural atherosclerotic process and could overlook subclinical myocardial infarctions (MIs). Contrast-enhanced magnetic resonance imaging (CE-MRI) noninvasively identifies infarct-typical subendocardial MI and focal nonischemic fibrosis. Infarct-typical CE-MRI was already present in TCAD I + II and increased significantly between groups (p < 0.05). Infarct-atypical CE-MRI was equally distributed across all TCAD stages (p = NS). Patients with only infarct-atypical CE-MRI had significantly better left ventricular function than with infarct-typical or combined patterns (p ≤ 0.05). CE-MRI allowed for identification of silent MI in apparently event-free HTX patients and disclosed focal nonischemic fibrosis already in early TCAD stages. |
| doi_str_mv | 10.1016/j.jacc.2008.05.059 |
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Katus Coronary angiography, which is routinely used for estimation of heart transplant (HTX) coronary artery disease (TCAD; I = mild; II = 30% to 75%, III = ≥75% stenosis), underestimates the intramural atherosclerotic process and could overlook subclinical myocardial infarctions (MIs). Contrast-enhanced magnetic resonance imaging (CE-MRI) noninvasively identifies infarct-typical subendocardial MI and focal nonischemic fibrosis. Infarct-typical CE-MRI was already present in TCAD I + II and increased significantly between groups (p < 0.05). Infarct-atypical CE-MRI was equally distributed across all TCAD stages (p = NS). Patients with only infarct-atypical CE-MRI had significantly better left ventricular function than with infarct-typical or combined patterns (p ≤ 0.05). CE-MRI allowed for identification of silent MI in apparently event-free HTX patients and disclosed focal nonischemic fibrosis already in early TCAD stages.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2008.05.059</identifier><identifier>PMID: 18804744</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Atherosclerosis ; Biopsy ; Cardiology ; Cardiomyopathy ; Cardiovascular ; Cardiovascular disease ; Chronic obstructive pulmonary disease ; Contrast agents ; Coronary Angiography ; coronary artery disease ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - etiology ; Data analysis ; Female ; Fibrosis ; Gadolinium ; Heart ; Heart attacks ; Heart Function Tests ; heart transplantation ; Heart Transplantation - adverse effects ; Humans ; Internal Medicine ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Middle Aged ; myocardial infarction ; Myocardial Infarction - pathology ; Myocardium - pathology ; NMR ; Nuclear magnetic resonance</subject><ispartof>Journal of the American College of Cardiology, 2008-09, Vol.52 (14), p.1160-1167</ispartof><rights>American College of Cardiology Foundation</rights><rights>2008 American College of Cardiology Foundation</rights><rights>Copyright Elsevier Limited Sep 30, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-1449a805425a8c9c174659f3983ee545652ddae640ca60dcefaa3c52914598703</citedby><cites>FETCH-LOGICAL-c473t-1449a805425a8c9c174659f3983ee545652ddae640ca60dcefaa3c52914598703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0735109708023978$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18804744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steen, Henning, MD</creatorcontrib><creatorcontrib>Merten, Constanze, MD</creatorcontrib><creatorcontrib>Refle, Sonja, MD</creatorcontrib><creatorcontrib>Klingenberg, Roland, MD</creatorcontrib><creatorcontrib>Dengler, Thomas, MD</creatorcontrib><creatorcontrib>Giannitsis, Evangelos, MD</creatorcontrib><creatorcontrib>Katus, Hugo A., MD</creatorcontrib><title>Prevalence of Different Gadolinium Enhancement Patterns in Patients After Heart Transplantation</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Prevalence of Different Gadolinium Enhancement Patterns in Patients After Heart Transplantation Henning Steen, Constanze Merten, Sonja Refle, Roland Klingenberg, Thomas Dengler, Evangelos Giannitsis, Hugo A. Katus Coronary angiography, which is routinely used for estimation of heart transplant (HTX) coronary artery disease (TCAD; I = mild; II = 30% to 75%, III = ≥75% stenosis), underestimates the intramural atherosclerotic process and could overlook subclinical myocardial infarctions (MIs). Contrast-enhanced magnetic resonance imaging (CE-MRI) noninvasively identifies infarct-typical subendocardial MI and focal nonischemic fibrosis. Infarct-typical CE-MRI was already present in TCAD I + II and increased significantly between groups (p < 0.05). Infarct-atypical CE-MRI was equally distributed across all TCAD stages (p = NS). Patients with only infarct-atypical CE-MRI had significantly better left ventricular function than with infarct-typical or combined patterns (p ≤ 0.05). CE-MRI allowed for identification of silent MI in apparently event-free HTX patients and disclosed focal nonischemic fibrosis already in early TCAD stages.</description><subject>Adult</subject><subject>Aged</subject><subject>Atherosclerosis</subject><subject>Biopsy</subject><subject>Cardiology</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Contrast agents</subject><subject>Coronary Angiography</subject><subject>coronary artery disease</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - etiology</subject><subject>Data analysis</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Gadolinium</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart Function Tests</subject><subject>heart transplantation</subject><subject>Heart Transplantation - adverse effects</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>myocardial infarction</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardium - pathology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UV1r3DAQFKWluST9A30ohkLffF1ZkiVBKYR8FgINJH0Wqrymcm35KtmB_PtK3EEgD4EFid2ZYXeGkI8UthRo-3XYDta5bQOgtiBy6TdkQ4VQNRNaviUbkEzUFLQ8IscpDQDQKqrfkyOqFHDJ-YaYu4iPdsTgsJr76sL3PUYMS3Vtu3n0wa9TdRn-2DyfSvvOLgvGkCofyt_nXqrO-tyrbtDGpXqINqTdaMOSp3M4Je96Oyb8cHhPyK-ry4fzm_r25_WP87Pb2nHJlppyrq0CwRthldOOSt4K3TOtGKLgohVN11lsOTjbQuewt5Y50WjKhVYS2An5stfdxfnfimkxk08Ox7wIzmsyrRZKCsUz8PML4DCvMeTdDG25AKrzFhnV7FEuzilF7M0u-snGJ0PBFPPNYIr5pphvQOTSmfTpIL3-nrB7phzczoBvewBmJx49RpOcL9Z3PqJbTDf71_W_v6C7kpCz4198wvR8h0mNAXNf4i_pg4KGaanYf0u7qbw</recordid><startdate>20080930</startdate><enddate>20080930</enddate><creator>Steen, Henning, MD</creator><creator>Merten, Constanze, MD</creator><creator>Refle, Sonja, MD</creator><creator>Klingenberg, Roland, MD</creator><creator>Dengler, Thomas, MD</creator><creator>Giannitsis, Evangelos, MD</creator><creator>Katus, Hugo A., MD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20080930</creationdate><title>Prevalence of Different Gadolinium Enhancement Patterns in Patients After Heart Transplantation</title><author>Steen, Henning, MD ; 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Katus Coronary angiography, which is routinely used for estimation of heart transplant (HTX) coronary artery disease (TCAD; I = mild; II = 30% to 75%, III = ≥75% stenosis), underestimates the intramural atherosclerotic process and could overlook subclinical myocardial infarctions (MIs). Contrast-enhanced magnetic resonance imaging (CE-MRI) noninvasively identifies infarct-typical subendocardial MI and focal nonischemic fibrosis. Infarct-typical CE-MRI was already present in TCAD I + II and increased significantly between groups (p < 0.05). Infarct-atypical CE-MRI was equally distributed across all TCAD stages (p = NS). Patients with only infarct-atypical CE-MRI had significantly better left ventricular function than with infarct-typical or combined patterns (p ≤ 0.05). CE-MRI allowed for identification of silent MI in apparently event-free HTX patients and disclosed focal nonischemic fibrosis already in early TCAD stages.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18804744</pmid><doi>10.1016/j.jacc.2008.05.059</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Atherosclerosis Biopsy Cardiology Cardiomyopathy Cardiovascular Cardiovascular disease Chronic obstructive pulmonary disease Contrast agents Coronary Angiography coronary artery disease Coronary Artery Disease - diagnosis Coronary Artery Disease - etiology Data analysis Female Fibrosis Gadolinium Heart Heart attacks Heart Function Tests heart transplantation Heart Transplantation - adverse effects Humans Internal Medicine Magnetic Resonance Imaging Male Medical imaging Middle Aged myocardial infarction Myocardial Infarction - pathology Myocardium - pathology NMR Nuclear magnetic resonance |
| title | Prevalence of Different Gadolinium Enhancement Patterns in Patients After Heart Transplantation |
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