Microvascular function relates to insulin sensitivity and blood pressure in normal subjects
A strong but presently unexplained inverse association between blood pressure and insulin sensitivity has been reported. Microvascular vasodilator capacity may be a common antecedent linking insulin sensitivity to blood pressure. To test this hypothesis, we studied 18 normotensive and glucose-tolera...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1999-02, Vol.99 (7), p.896-902 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | SERNE, E. H STEHOUWER, C. D. A TER MAATEN, J. C TER WEE, P. M RAUWERDA, J. A DONKER, A. J. M GANS, R. O. B |
| description | A strong but presently unexplained inverse association between blood pressure and insulin sensitivity has been reported. Microvascular vasodilator capacity may be a common antecedent linking insulin sensitivity to blood pressure. To test this hypothesis, we studied 18 normotensive and glucose-tolerant subjects showing a wide range in insulin sensitivity as assessed with the hyperinsulinemic, euglycemic clamp technique.
Blood pressure was measured by 24-hour ambulatory blood pressure monitoring. Videomicroscopy was used to measure skin capillary density and capillary recruitment after arterial occlusion. Skin blood flow responses after iontophoresis of acetylcholine and sodium nitroprusside were evaluated by laser Doppler flowmetry. Insulin sensitivity correlated with 24-hour systolic blood pressure (24-hour SBP; r=-0.50, P |
| doi_str_mv | 10.1161/01.cir.99.7.896 |
| format | Article |
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Blood pressure was measured by 24-hour ambulatory blood pressure monitoring. Videomicroscopy was used to measure skin capillary density and capillary recruitment after arterial occlusion. Skin blood flow responses after iontophoresis of acetylcholine and sodium nitroprusside were evaluated by laser Doppler flowmetry. Insulin sensitivity correlated with 24-hour systolic blood pressure (24-hour SBP; r=-0.50, P<0.05). Capillary recruitment and acetylcholine-mediated vasodilatation were strongly and positively related to insulin sensitivity (r=0.84, P<0.001; r=0.78, P<0.001, respectively), and capillary recruitment was inversely related to 24-hour SBP (r=-0.53, P<0.05). Waist-to-hip ratio showed strong associations with insulin sensitivity, blood pressure, and the measures of microvascular function but did not confound the associations between these variables. Subsequent regression analysis showed that the association between insulin sensitivity and blood pressure was not independent of the estimates of microvascular function, and part of the variation in both blood pressure (R2=38%) and insulin sensitivity (R2=71%) could be explained by microvascular function.
Insulin sensitivity and blood pressure are associated well within the physiological range. Microvascular function strongly relates to both, consistent with a central role in linking these variables.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.cir.99.7.896</identifier><identifier>PMID: 10027812</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - physiology ; Capillaries - physiology ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Endothelium, Vascular - physiology ; Female ; Heart Rate - physiology ; Humans ; Insulin Resistance - physiology ; Male ; Medical sciences ; Middle Aged ; Reference Values ; Regression Analysis ; Skin - blood supply ; Vasodilation - physiology</subject><ispartof>Circulation (New York, N.Y.), 1999-02, Vol.99 (7), p.896-902</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Feb 23, 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-9eb9e8c7c6eccb64f456e9e26fbed9a860ff60e3ba5e05f0651f9741683a67623</citedby><cites>FETCH-LOGICAL-c542t-9eb9e8c7c6eccb64f456e9e26fbed9a860ff60e3ba5e05f0651f9741683a67623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1693851$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10027812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SERNE, E. H</creatorcontrib><creatorcontrib>STEHOUWER, C. D. A</creatorcontrib><creatorcontrib>TER MAATEN, J. C</creatorcontrib><creatorcontrib>TER WEE, P. M</creatorcontrib><creatorcontrib>RAUWERDA, J. A</creatorcontrib><creatorcontrib>DONKER, A. J. M</creatorcontrib><creatorcontrib>GANS, R. O. B</creatorcontrib><title>Microvascular function relates to insulin sensitivity and blood pressure in normal subjects</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>A strong but presently unexplained inverse association between blood pressure and insulin sensitivity has been reported. Microvascular vasodilator capacity may be a common antecedent linking insulin sensitivity to blood pressure. To test this hypothesis, we studied 18 normotensive and glucose-tolerant subjects showing a wide range in insulin sensitivity as assessed with the hyperinsulinemic, euglycemic clamp technique.
Blood pressure was measured by 24-hour ambulatory blood pressure monitoring. Videomicroscopy was used to measure skin capillary density and capillary recruitment after arterial occlusion. Skin blood flow responses after iontophoresis of acetylcholine and sodium nitroprusside were evaluated by laser Doppler flowmetry. Insulin sensitivity correlated with 24-hour systolic blood pressure (24-hour SBP; r=-0.50, P<0.05). Capillary recruitment and acetylcholine-mediated vasodilatation were strongly and positively related to insulin sensitivity (r=0.84, P<0.001; r=0.78, P<0.001, respectively), and capillary recruitment was inversely related to 24-hour SBP (r=-0.53, P<0.05). Waist-to-hip ratio showed strong associations with insulin sensitivity, blood pressure, and the measures of microvascular function but did not confound the associations between these variables. Subsequent regression analysis showed that the association between insulin sensitivity and blood pressure was not independent of the estimates of microvascular function, and part of the variation in both blood pressure (R2=38%) and insulin sensitivity (R2=71%) could be explained by microvascular function.
Insulin sensitivity and blood pressure are associated well within the physiological range. Microvascular function strongly relates to both, consistent with a central role in linking these variables.</description><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - physiology</subject><subject>Capillaries - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Endothelium, Vascular - physiology</subject><subject>Female</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Skin - blood supply</subject><subject>Vasodilation - physiology</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0M9rFDEUwPEgFru2nr1JEPE20_yYJJOjLFULlYLoqYeQyb5AlmyyJpNC_3sju6B4egQ-eTy-CL2lZKRU0htCRxfKqPWoxlnLF2hDBZuGSXD9Em0IIXpQnLFL9LrWfX9KrsQrdEkJYWqmbIMevwVX8pOtrkVbsG_JrSEnXCDaFSpeMw6pthgSrpBqWMNTWJ-xTTu8xJx3-Fig1lagM5xyOdiIa1v24NZ6jS68jRXenOcV-vn59sf263D_8OVu--l-cGJi66Bh0TA75SQ4t8jJT0KCBib9AjttZ0m8lwT4YgUQ4YkU1Gs1UTlzK5Vk_Ap9PO09lvyrQV3NIVQHMdoEuVUjtZgV5VOH7_-D-9xK6rcZRpma5pnyjm5OqHeptYA3xxIOtjwbSsyf6IZQs737brQ2yvTo_ce789q2HGD3jz9V7uDDGfTONvpikwv1r5Oaz4Ly3_bdi3Q</recordid><startdate>19990223</startdate><enddate>19990223</enddate><creator>SERNE, E. H</creator><creator>STEHOUWER, C. D. A</creator><creator>TER MAATEN, J. C</creator><creator>TER WEE, P. M</creator><creator>RAUWERDA, J. A</creator><creator>DONKER, A. J. M</creator><creator>GANS, R. O. B</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19990223</creationdate><title>Microvascular function relates to insulin sensitivity and blood pressure in normal subjects</title><author>SERNE, E. H ; STEHOUWER, C. D. A ; TER MAATEN, J. C ; TER WEE, P. M ; RAUWERDA, J. A ; DONKER, A. J. M ; GANS, R. O. 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Etiology</topic><topic>Endothelium, Vascular - physiology</topic><topic>Female</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Skin - blood supply</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SERNE, E. H</creatorcontrib><creatorcontrib>STEHOUWER, C. D. A</creatorcontrib><creatorcontrib>TER MAATEN, J. C</creatorcontrib><creatorcontrib>TER WEE, P. M</creatorcontrib><creatorcontrib>RAUWERDA, J. A</creatorcontrib><creatorcontrib>DONKER, A. J. M</creatorcontrib><creatorcontrib>GANS, R. O. 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B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microvascular function relates to insulin sensitivity and blood pressure in normal subjects</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1999-02-23</date><risdate>1999</risdate><volume>99</volume><issue>7</issue><spage>896</spage><epage>902</epage><pages>896-902</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>A strong but presently unexplained inverse association between blood pressure and insulin sensitivity has been reported. Microvascular vasodilator capacity may be a common antecedent linking insulin sensitivity to blood pressure. To test this hypothesis, we studied 18 normotensive and glucose-tolerant subjects showing a wide range in insulin sensitivity as assessed with the hyperinsulinemic, euglycemic clamp technique.
Blood pressure was measured by 24-hour ambulatory blood pressure monitoring. Videomicroscopy was used to measure skin capillary density and capillary recruitment after arterial occlusion. Skin blood flow responses after iontophoresis of acetylcholine and sodium nitroprusside were evaluated by laser Doppler flowmetry. Insulin sensitivity correlated with 24-hour systolic blood pressure (24-hour SBP; r=-0.50, P<0.05). Capillary recruitment and acetylcholine-mediated vasodilatation were strongly and positively related to insulin sensitivity (r=0.84, P<0.001; r=0.78, P<0.001, respectively), and capillary recruitment was inversely related to 24-hour SBP (r=-0.53, P<0.05). Waist-to-hip ratio showed strong associations with insulin sensitivity, blood pressure, and the measures of microvascular function but did not confound the associations between these variables. Subsequent regression analysis showed that the association between insulin sensitivity and blood pressure was not independent of the estimates of microvascular function, and part of the variation in both blood pressure (R2=38%) and insulin sensitivity (R2=71%) could be explained by microvascular function.
Insulin sensitivity and blood pressure are associated well within the physiological range. Microvascular function strongly relates to both, consistent with a central role in linking these variables.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10027812</pmid><doi>10.1161/01.cir.99.7.896</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 1999-02, Vol.99 (7), p.896-902 |
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| source | Journals@Ovid Ovid Autoload; MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology Capillaries - physiology Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Endothelium, Vascular - physiology Female Heart Rate - physiology Humans Insulin Resistance - physiology Male Medical sciences Middle Aged Reference Values Regression Analysis Skin - blood supply Vasodilation - physiology |
| title | Microvascular function relates to insulin sensitivity and blood pressure in normal subjects |
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