Differential expression of C-protein isoforms in developing and degenerating mouse striated muscles
With the aim of clarifying the roles of C‐protein isoforms in developing mammalian skeletal muscle, we cloned the complementary DNA (cDNAs) encoding mouse fast (F) and slow (S) skeletal muscle C‐proteins and determined their entire sequences. Northern blotting with these cDNAs together with mouse ca...
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| Veröffentlicht in: | Muscle & nerve 1999-02, Vol.22 (2), p.196-207 |
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| creator | Kurasawa, Mariko Sato, Naruki Matsuda, Ayako Koshida, Sumito Totsuka, Tsuyoshi Obinata, Takashi |
| description | With the aim of clarifying the roles of C‐protein isoforms in developing mammalian skeletal muscle, we cloned the complementary DNA (cDNAs) encoding mouse fast (F) and slow (S) skeletal muscle C‐proteins and determined their entire sequences. Northern blotting with these cDNAs together with mouse cardiac (C) C‐protein cDNA was performed. It revealed that in adult mice, C, F, and S isoforms are expressed in a tissue‐specific fashion, although the messages for both F and S isoforms are transcribed in extensor digitorum longus muscle, which has been categorized as a fast muscle. In addition, although C isoform is expressed first and transiently during development of chicken skeletal muscles, C isoform is not expressed in mouse skeletal muscles at all through the developmental stages; S isoform is first expressed, followed by the appearance of F isoform. Finally, in dystrophic mouse skeletal muscles, the expression of S isoform is increased as it is in dystrophic chicken muscle. These observations suggest that mutations in C isoform (MyBP‐C) do not lead to any disturbance in skeletal muscle, although they may lead to familial hypertrophic cardiomyopathy. We also suggest that the expression of S isoform may be stimulated in degenerating human dystrophic muscles. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 196–207, 1999 |
| doi_str_mv | 10.1002/(SICI)1097-4598(199902)22:2<196::AID-MUS7>3.0.CO;2-E |
| format | Article |
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Northern blotting with these cDNAs together with mouse cardiac (C) C‐protein cDNA was performed. It revealed that in adult mice, C, F, and S isoforms are expressed in a tissue‐specific fashion, although the messages for both F and S isoforms are transcribed in extensor digitorum longus muscle, which has been categorized as a fast muscle. In addition, although C isoform is expressed first and transiently during development of chicken skeletal muscles, C isoform is not expressed in mouse skeletal muscles at all through the developmental stages; S isoform is first expressed, followed by the appearance of F isoform. Finally, in dystrophic mouse skeletal muscles, the expression of S isoform is increased as it is in dystrophic chicken muscle. These observations suggest that mutations in C isoform (MyBP‐C) do not lead to any disturbance in skeletal muscle, although they may lead to familial hypertrophic cardiomyopathy. We also suggest that the expression of S isoform may be stimulated in degenerating human dystrophic muscles. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 196–207, 1999</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/(SICI)1097-4598(199902)22:2<196::AID-MUS7>3.0.CO;2-E</identifier><identifier>PMID: 10024132</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Biological and medical sciences ; Blotting, Northern ; C-protein ; Carrier Proteins ; cDNA cloning ; Cloning, Molecular ; Diseases of striated muscles. Neuromuscular diseases ; DNA, Complementary - analysis ; Gene Expression Regulation, Developmental ; Humans ; Laminin - genetics ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Mice, Knockout ; Molecular Sequence Data ; mouse muscle development ; Muscle Development ; Muscle Fibers, Fast-Twitch - metabolism ; Muscle Fibers, Slow-Twitch - metabolism ; Muscle Proteins - genetics ; Muscle, Skeletal - growth & development ; Muscle, Skeletal - metabolism ; muscular dystrophy ; Muscular Dystrophy, Animal - genetics ; Muscular Dystrophy, Animal - metabolism ; Myocardium - metabolism ; myosin-binding protein ; Neurology ; Protein Isoforms - genetics ; RNA, Messenger - biosynthesis ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Space life sciences</subject><ispartof>Muscle & nerve, 1999-02, Vol.22 (2), p.196-207</ispartof><rights>Copyright © 1999 John Wiley & Sons, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4947-54c60c4bcaa26b041e30168e7c1d1ba2003e4eb41a4f6edba06e58c24381bbe33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-4598%28199902%2922%3A2%3C196%3A%3AAID-MUS7%3E3.0.CO%3B2-E$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-4598%28199902%2922%3A2%3C196%3A%3AAID-MUS7%3E3.0.CO%3B2-E$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1779069$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10024132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurasawa, Mariko</creatorcontrib><creatorcontrib>Sato, Naruki</creatorcontrib><creatorcontrib>Matsuda, Ayako</creatorcontrib><creatorcontrib>Koshida, Sumito</creatorcontrib><creatorcontrib>Totsuka, Tsuyoshi</creatorcontrib><creatorcontrib>Obinata, Takashi</creatorcontrib><title>Differential expression of C-protein isoforms in developing and degenerating mouse striated muscles</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>With the aim of clarifying the roles of C‐protein isoforms in developing mammalian skeletal muscle, we cloned the complementary DNA (cDNAs) encoding mouse fast (F) and slow (S) skeletal muscle C‐proteins and determined their entire sequences. Northern blotting with these cDNAs together with mouse cardiac (C) C‐protein cDNA was performed. It revealed that in adult mice, C, F, and S isoforms are expressed in a tissue‐specific fashion, although the messages for both F and S isoforms are transcribed in extensor digitorum longus muscle, which has been categorized as a fast muscle. In addition, although C isoform is expressed first and transiently during development of chicken skeletal muscles, C isoform is not expressed in mouse skeletal muscles at all through the developmental stages; S isoform is first expressed, followed by the appearance of F isoform. Finally, in dystrophic mouse skeletal muscles, the expression of S isoform is increased as it is in dystrophic chicken muscle. These observations suggest that mutations in C isoform (MyBP‐C) do not lead to any disturbance in skeletal muscle, although they may lead to familial hypertrophic cardiomyopathy. We also suggest that the expression of S isoform may be stimulated in degenerating human dystrophic muscles. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 196–207, 1999</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>C-protein</subject><subject>Carrier Proteins</subject><subject>cDNA cloning</subject><subject>Cloning, Molecular</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>DNA, Complementary - analysis</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Humans</subject><subject>Laminin - genetics</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred ICR</subject><subject>Mice, Knockout</subject><subject>Molecular Sequence Data</subject><subject>mouse muscle development</subject><subject>Muscle Development</subject><subject>Muscle Fibers, Fast-Twitch - metabolism</subject><subject>Muscle Fibers, Slow-Twitch - metabolism</subject><subject>Muscle Proteins - genetics</subject><subject>Muscle, Skeletal - growth & development</subject><subject>Muscle, Skeletal - metabolism</subject><subject>muscular dystrophy</subject><subject>Muscular Dystrophy, Animal - genetics</subject><subject>Muscular Dystrophy, Animal - metabolism</subject><subject>Myocardium - metabolism</subject><subject>myosin-binding protein</subject><subject>Neurology</subject><subject>Protein Isoforms - genetics</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Space life sciences</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtv1DAQhSMEotuFv4DygFD7kMW3OPFSIbXptqwo7ENbwdvIcSaVIZfFzpb23-OwqxYJJCRLnhkdnzn-ouiIkhklhL09uFwWy0NKVJaIVOUHVClF2CFjc3ZElZzPj5enyafry-w9n5FZsXrHksWTaPLw4Gk0IVTkieTq61607_03QgjNZfY82hsXCMrZJDKntq7RYTdY3cR4t3bove27uK_jIlm7fkDbxdb3de9aH4e6wlts-rXtbmLdVaG9wQ6dHsZB2288xn5wVg9Yxe3Gmwb9i-hZrRuPL3f3NLo-W1wVH5KL1fmyOL5IjFAiS1JhJDGiNFozWRJBkRMqc8wMrWipGSEcBZaCalFLrEpNJKa5YYLntCyR82n0ZusbYv_YoB-gtd5g0-gOQzCQKs1TGv49ja62QuN67x3WsHa21e4eKIGRDcAIH0aWMLKELXxg4YRaAgT4MMIHDgSKVRgvgu2r3f5N2WL1h-mWdhC83gm0N7qpne6M9Y-6LFNEqsd4P22D939l-0-0fyT73QfbZGtr_YB3D7bafQeZ8SyFL5_P4Yyl4qM4OQHOfwF467yG</recordid><startdate>199902</startdate><enddate>199902</enddate><creator>Kurasawa, Mariko</creator><creator>Sato, Naruki</creator><creator>Matsuda, Ayako</creator><creator>Koshida, Sumito</creator><creator>Totsuka, Tsuyoshi</creator><creator>Obinata, Takashi</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199902</creationdate><title>Differential expression of C-protein isoforms in developing and degenerating mouse striated muscles</title><author>Kurasawa, Mariko ; Sato, Naruki ; Matsuda, Ayako ; Koshida, Sumito ; Totsuka, Tsuyoshi ; Obinata, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4947-54c60c4bcaa26b041e30168e7c1d1ba2003e4eb41a4f6edba06e58c24381bbe33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>C-protein</topic><topic>Carrier Proteins</topic><topic>cDNA cloning</topic><topic>Cloning, Molecular</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>DNA, Complementary - analysis</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Humans</topic><topic>Laminin - genetics</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred ICR</topic><topic>Mice, Knockout</topic><topic>Molecular Sequence Data</topic><topic>mouse muscle development</topic><topic>Muscle Development</topic><topic>Muscle Fibers, Fast-Twitch - metabolism</topic><topic>Muscle Fibers, Slow-Twitch - metabolism</topic><topic>Muscle Proteins - genetics</topic><topic>Muscle, Skeletal - growth & development</topic><topic>Muscle, Skeletal - metabolism</topic><topic>muscular dystrophy</topic><topic>Muscular Dystrophy, Animal - genetics</topic><topic>Muscular Dystrophy, Animal - metabolism</topic><topic>Myocardium - metabolism</topic><topic>myosin-binding protein</topic><topic>Neurology</topic><topic>Protein Isoforms - genetics</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurasawa, Mariko</creatorcontrib><creatorcontrib>Sato, Naruki</creatorcontrib><creatorcontrib>Matsuda, Ayako</creatorcontrib><creatorcontrib>Koshida, Sumito</creatorcontrib><creatorcontrib>Totsuka, Tsuyoshi</creatorcontrib><creatorcontrib>Obinata, Takashi</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurasawa, Mariko</au><au>Sato, Naruki</au><au>Matsuda, Ayako</au><au>Koshida, Sumito</au><au>Totsuka, Tsuyoshi</au><au>Obinata, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential expression of C-protein isoforms in developing and degenerating mouse striated muscles</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>1999-02</date><risdate>1999</risdate><volume>22</volume><issue>2</issue><spage>196</spage><epage>207</epage><pages>196-207</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>With the aim of clarifying the roles of C‐protein isoforms in developing mammalian skeletal muscle, we cloned the complementary DNA (cDNAs) encoding mouse fast (F) and slow (S) skeletal muscle C‐proteins and determined their entire sequences. Northern blotting with these cDNAs together with mouse cardiac (C) C‐protein cDNA was performed. It revealed that in adult mice, C, F, and S isoforms are expressed in a tissue‐specific fashion, although the messages for both F and S isoforms are transcribed in extensor digitorum longus muscle, which has been categorized as a fast muscle. In addition, although C isoform is expressed first and transiently during development of chicken skeletal muscles, C isoform is not expressed in mouse skeletal muscles at all through the developmental stages; S isoform is first expressed, followed by the appearance of F isoform. Finally, in dystrophic mouse skeletal muscles, the expression of S isoform is increased as it is in dystrophic chicken muscle. These observations suggest that mutations in C isoform (MyBP‐C) do not lead to any disturbance in skeletal muscle, although they may lead to familial hypertrophic cardiomyopathy. We also suggest that the expression of S isoform may be stimulated in degenerating human dystrophic muscles. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 196–207, 1999</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10024132</pmid><doi>10.1002/(SICI)1097-4598(199902)22:2<196::AID-MUS7>3.0.CO;2-E</doi><tpages>12</tpages></addata></record> |
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| ispartof | Muscle & nerve, 1999-02, Vol.22 (2), p.196-207 |
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| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences Blotting, Northern C-protein Carrier Proteins cDNA cloning Cloning, Molecular Diseases of striated muscles. Neuromuscular diseases DNA, Complementary - analysis Gene Expression Regulation, Developmental Humans Laminin - genetics Medical sciences Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Knockout Molecular Sequence Data mouse muscle development Muscle Development Muscle Fibers, Fast-Twitch - metabolism Muscle Fibers, Slow-Twitch - metabolism Muscle Proteins - genetics Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism muscular dystrophy Muscular Dystrophy, Animal - genetics Muscular Dystrophy, Animal - metabolism Myocardium - metabolism myosin-binding protein Neurology Protein Isoforms - genetics RNA, Messenger - biosynthesis Sequence Analysis, DNA Sequence Homology, Amino Acid Space life sciences |
| title | Differential expression of C-protein isoforms in developing and degenerating mouse striated muscles |
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