Chronic urotensin II infusion enhances macrophage foam cell formation and atherosclerosis in apolipoprotein E-knockout mice

Our recent studies have indicated that urotensin II, the most potent vasoconstrictor peptide identified to date, potentiates human macrophage foam cell formation and vascular smooth muscle cell proliferation, and its levels are increased in the plasma of hypertensive patients with carotid atheroscle...

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Veröffentlicht in:	Journal of hypertension 2008-10, Vol.26 (10), p.1955-1965
Hauptverfasser:	SHIRAISHI, Yuji, WATANABE, Takuya, SUGURO, Toshiaki, NAGASHIMA, Masaharu, KATO, Rina, HONGO, Shigeki, ITABE, Hiroyuki, MIYAZAKI, Akira, HIRANO, Tsutomu, ADACHI, Mitsuru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - genetics Arterial hypertension. Arterial hypotension Atherosclerosis - physiopathology Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system CD36 Antigens - metabolism Diet, Atherogenic Foam Cells - physiology Fundamental and applied biological sciences. Psychology Lipoproteins, LDL - metabolism Male Medical sciences Mice Mice, Knockout Reactive Oxygen Species - metabolism Scavenger Receptors, Class A - metabolism Sterol O-Acyltransferase - metabolism Urotensins - physiology Vertebrates: cardiovascular system
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