Endocannabinoids as positive or negative factors in hematopoietic cell migration and differentiation
The ethanolamides of arachidonic, myristic and linoleic acids reduce bone marrow cell migration, while the 2-glyceryl esters of these acids enhance migration. Thus the 2 major endocannabinoids, anandamide (arachidonoyl ethanolamide) and 2-AG (2-arachidonoyl glycerol), whose structural difference lie...
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description | The ethanolamides of arachidonic, myristic and linoleic acids reduce bone marrow cell migration, while the 2-glyceryl esters of these acids enhance migration. Thus the 2 major endocannabinoids, anandamide (arachidonoyl ethanolamide) and 2-AG (2-arachidonoyl glycerol), whose structural difference lies in the nature of the end-group alone, work in opposite directions. The endocannabinoid arachidonoyl serine, a vasodilator, also reduces migration. The effect of 2-AG is mediated, in part at least, through the cannabinoid receptors, while the effect of anandamide, as well as the rest of the compounds assayed, are not mediated through them. Almost all cannabinoids tested, including anandamide and 2-AG, lead to approximate doubling of CFU-GEMM (colony-forming unit: granulocyte, erythrocyte, macrophage, megakaryocyte) colonies. The effect of anandamide is considerably more potent than that of 2-AG. A surprising dose–response increase of erythroid cells is noted in cultures with the ester cannabinoids (in the absence of the cytokine erythropoietin), while a considerable dose–response augmentation of megakaryocytes is noted in cultures with the ethanolamide cannabinoids (in the presence of erythropoietin). This is suggestive of some cross-talk between two different regulatory systems, one governed by glycoprotein ligands and the other by endocannabinoids. |
doi_str_mv | 10.1016/j.ejphar.2008.05.002 |
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Thus the 2 major endocannabinoids, anandamide (arachidonoyl ethanolamide) and 2-AG (2-arachidonoyl glycerol), whose structural difference lies in the nature of the end-group alone, work in opposite directions. The endocannabinoid arachidonoyl serine, a vasodilator, also reduces migration. The effect of 2-AG is mediated, in part at least, through the cannabinoid receptors, while the effect of anandamide, as well as the rest of the compounds assayed, are not mediated through them. Almost all cannabinoids tested, including anandamide and 2-AG, lead to approximate doubling of CFU-GEMM (colony-forming unit: granulocyte, erythrocyte, macrophage, megakaryocyte) colonies. The effect of anandamide is considerably more potent than that of 2-AG. A surprising dose–response increase of erythroid cells is noted in cultures with the ester cannabinoids (in the absence of the cytokine erythropoietin), while a considerable dose–response augmentation of megakaryocytes is noted in cultures with the ethanolamide cannabinoids (in the presence of erythropoietin). This is suggestive of some cross-talk between two different regulatory systems, one governed by glycoprotein ligands and the other by endocannabinoids.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2008.05.002</identifier><identifier>PMID: 18778813</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Bone Marrow Cells - metabolism ; Cannabinoid receptor CB 1 ; Cannabinoid receptor CB 2 ; Cannabinoid Receptor Modulators - metabolism ; Cell Differentiation ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Colony-Forming Units Assay ; Endocannabinoids ; Ethanolamide cannabinoids ; Glycerol - analogs & derivatives ; Glycerol - metabolism ; Glycerol cannabinoids ; Hematopoietic Stem Cells - metabolism ; Medical sciences ; Mice ; Mice, Inbred C3H ; Pharmacology. Drug treatments ; Polyunsaturated Alkamides - metabolism ; Receptor, Cannabinoid, CB1 - metabolism ; Receptor, Cannabinoid, CB2 - metabolism</subject><ispartof>European journal of pharmacology, 2008-10, Vol.595 (1), p.1-6</ispartof><rights>2008 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-25498bb42d446a5172ed3a5407ea0ea38ad988b06c21af6a0ea94f192b5ca0f43</citedby><cites>FETCH-LOGICAL-c390t-25498bb42d446a5172ed3a5407ea0ea38ad988b06c21af6a0ea94f192b5ca0f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2008.05.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20714536$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18778813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patinkin, Deborah</creatorcontrib><creatorcontrib>Milman, Garry</creatorcontrib><creatorcontrib>Breuer, Aviva</creatorcontrib><creatorcontrib>Fride, Ester</creatorcontrib><creatorcontrib>Mechoulam, Raphael</creatorcontrib><title>Endocannabinoids as positive or negative factors in hematopoietic cell migration and differentiation</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The ethanolamides of arachidonic, myristic and linoleic acids reduce bone marrow cell migration, while the 2-glyceryl esters of these acids enhance migration. Thus the 2 major endocannabinoids, anandamide (arachidonoyl ethanolamide) and 2-AG (2-arachidonoyl glycerol), whose structural difference lies in the nature of the end-group alone, work in opposite directions. The endocannabinoid arachidonoyl serine, a vasodilator, also reduces migration. The effect of 2-AG is mediated, in part at least, through the cannabinoid receptors, while the effect of anandamide, as well as the rest of the compounds assayed, are not mediated through them. Almost all cannabinoids tested, including anandamide and 2-AG, lead to approximate doubling of CFU-GEMM (colony-forming unit: granulocyte, erythrocyte, macrophage, megakaryocyte) colonies. The effect of anandamide is considerably more potent than that of 2-AG. A surprising dose–response increase of erythroid cells is noted in cultures with the ester cannabinoids (in the absence of the cytokine erythropoietin), while a considerable dose–response augmentation of megakaryocytes is noted in cultures with the ethanolamide cannabinoids (in the presence of erythropoietin). This is suggestive of some cross-talk between two different regulatory systems, one governed by glycoprotein ligands and the other by endocannabinoids.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Cells - metabolism</subject><subject>Cannabinoid receptor CB 1</subject><subject>Cannabinoid receptor CB 2</subject><subject>Cannabinoid Receptor Modulators - metabolism</subject><subject>Cell Differentiation</subject><subject>Cell Movement</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Colony-Forming Units Assay</subject><subject>Endocannabinoids</subject><subject>Ethanolamide cannabinoids</subject><subject>Glycerol - analogs & derivatives</subject><subject>Glycerol - metabolism</subject><subject>Glycerol cannabinoids</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyunsaturated Alkamides - metabolism</subject><subject>Receptor, Cannabinoid, CB1 - metabolism</subject><subject>Receptor, Cannabinoid, CB2 - metabolism</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFq3DAQhkVoaTZJ3yAUXdqb3ZEs2dalUELaFAK9NGcxlsaJlrXkSt5A3z7e7NLeepph-P5h-IaxawG1ANF-3ta0nZ8w1xKgr0HXAPKMbUTfmQo6Id-wDYBQlTTGnLOLUrYAoI3U79j5CnV9L5oN87fRJ4cx4hBiCr5wLHxOJSzhmXjKPNIjvvYjuiXlwkPkTzThkuYUaAmOO9rt-BQe88qlyDF67sM4Uqa4hNfZFXs74q7Q-1O9ZA_fbn_d3FX3P7__uPl6X7nGwFJJrUw_DEp6pVrUopPkG9QKOkIgbHr0pu8HaJ0UOLaHmVGjMHLQDmFUzSX7dNw75_R7T2WxUyiH8zBS2hfbGt03XdesoDqCLqdSMo12zmHC_McKsAe7dmuPdu3BrgVtV7tr7MNp_36YyP8LnXSuwMcTgMXhbswYXSh_Obn-RemmXbkvR45WG8-Bsi0uUHTkQya3WJ_C_y95AZtGnBc</recordid><startdate>20081024</startdate><enddate>20081024</enddate><creator>Patinkin, Deborah</creator><creator>Milman, Garry</creator><creator>Breuer, Aviva</creator><creator>Fride, Ester</creator><creator>Mechoulam, Raphael</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081024</creationdate><title>Endocannabinoids as positive or negative factors in hematopoietic cell migration and differentiation</title><author>Patinkin, Deborah ; Milman, Garry ; Breuer, Aviva ; Fride, Ester ; Mechoulam, Raphael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-25498bb42d446a5172ed3a5407ea0ea38ad988b06c21af6a0ea94f192b5ca0f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Cells - metabolism</topic><topic>Cannabinoid receptor CB 1</topic><topic>Cannabinoid receptor CB 2</topic><topic>Cannabinoid Receptor Modulators - metabolism</topic><topic>Cell Differentiation</topic><topic>Cell Movement</topic><topic>Cell Proliferation</topic><topic>Cells, Cultured</topic><topic>Colony-Forming Units Assay</topic><topic>Endocannabinoids</topic><topic>Ethanolamide cannabinoids</topic><topic>Glycerol - analogs & derivatives</topic><topic>Glycerol - metabolism</topic><topic>Glycerol cannabinoids</topic><topic>Hematopoietic Stem Cells - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyunsaturated Alkamides - metabolism</topic><topic>Receptor, Cannabinoid, CB1 - metabolism</topic><topic>Receptor, Cannabinoid, CB2 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patinkin, Deborah</creatorcontrib><creatorcontrib>Milman, Garry</creatorcontrib><creatorcontrib>Breuer, Aviva</creatorcontrib><creatorcontrib>Fride, Ester</creatorcontrib><creatorcontrib>Mechoulam, Raphael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patinkin, Deborah</au><au>Milman, Garry</au><au>Breuer, Aviva</au><au>Fride, Ester</au><au>Mechoulam, Raphael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocannabinoids as positive or negative factors in hematopoietic cell migration and differentiation</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2008-10-24</date><risdate>2008</risdate><volume>595</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The ethanolamides of arachidonic, myristic and linoleic acids reduce bone marrow cell migration, while the 2-glyceryl esters of these acids enhance migration. Thus the 2 major endocannabinoids, anandamide (arachidonoyl ethanolamide) and 2-AG (2-arachidonoyl glycerol), whose structural difference lies in the nature of the end-group alone, work in opposite directions. The endocannabinoid arachidonoyl serine, a vasodilator, also reduces migration. The effect of 2-AG is mediated, in part at least, through the cannabinoid receptors, while the effect of anandamide, as well as the rest of the compounds assayed, are not mediated through them. Almost all cannabinoids tested, including anandamide and 2-AG, lead to approximate doubling of CFU-GEMM (colony-forming unit: granulocyte, erythrocyte, macrophage, megakaryocyte) colonies. The effect of anandamide is considerably more potent than that of 2-AG. A surprising dose–response increase of erythroid cells is noted in cultures with the ester cannabinoids (in the absence of the cytokine erythropoietin), while a considerable dose–response augmentation of megakaryocytes is noted in cultures with the ethanolamide cannabinoids (in the presence of erythropoietin). This is suggestive of some cross-talk between two different regulatory systems, one governed by glycoprotein ligands and the other by endocannabinoids.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18778813</pmid><doi>10.1016/j.ejphar.2008.05.002</doi><tpages>6</tpages></addata></record> |
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subjects | Animals Biological and medical sciences Bone Marrow Cells - metabolism Cannabinoid receptor CB 1 Cannabinoid receptor CB 2 Cannabinoid Receptor Modulators - metabolism Cell Differentiation Cell Movement Cell Proliferation Cells, Cultured Colony-Forming Units Assay Endocannabinoids Ethanolamide cannabinoids Glycerol - analogs & derivatives Glycerol - metabolism Glycerol cannabinoids Hematopoietic Stem Cells - metabolism Medical sciences Mice Mice, Inbred C3H Pharmacology. Drug treatments Polyunsaturated Alkamides - metabolism Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB2 - metabolism |
title | Endocannabinoids as positive or negative factors in hematopoietic cell migration and differentiation |
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