Functional contribution of alpha3L8' to the neuronal nicotinic alpha3 receptor

The role of position L8', located in transmembrane domain 1 of the neuronal nicotinic alpha3 subunit, was characterized by using two-electrode voltage clamp in Xenopus oocytes. Four amino acids (Ala, Ser, Phe, and Tyr) were inserted at this conserved position, and the mutant subunit was coexpre...

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Veröffentlicht in:	Journal of neuroscience research 2008-10, Vol.86 (13), p.2884-2894
Hauptverfasser:	Nieves-Cintrón, Madeline, Caballero-Rivera, Daniel, Silva, Walter I, Navedo, Manuel F, Lasalde-Dominicci, José A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Amino Acid Sequence Animals Dimethylphenylpiperazinium Iodide - pharmacology Molecular Sequence Data Mutation Neurons - drug effects Neurons - metabolism Nicotine - pharmacology Nicotinic Agonists - pharmacology Nicotinic Antagonists - pharmacology Patch-Clamp Techniques Rats Receptors, Nicotinic - chemistry Receptors, Nicotinic - genetics Receptors, Nicotinic - metabolism Xenopus
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